DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mon2 and Mon2

DIOPT Version :9

Sequence 1:	NP_001033884.2	Gene:	mon2 / 326157	FlyBaseID:	FBgn0031985	Length:	1684	Species:	Drosophila melanogaster
Sequence 2:	XP_038935067.1	Gene:	Mon2 / 314894	RGDID:	1308808	Length:	1715	Species:	Rattus norvegicus

Alignment Length:	1770	Identity:	827/1770 - (46%)
Similarity:	1125/1770 - (63%)	Gaps:	187/1770 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VHKFVEALQADFKTLSLETKKKYPQIKEACEEAISKLCTAGSS--------QQNSVYYTVNQILY 70
            |.|.:|.:|:|.:.||||.|||:|.:|||.|..|.|:.|..:.        ::||     ::::.
  Rat    10 VKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENS-----SEVVQ 69

  Fly    71 PLVQGCETKDLKIIKFCLGMMQRLITQQVVDQKGALYITNALWTLMENNIEEVKVLQTVTLLLTT 135
            |.:.||.||:.|:.:.||..:|||::.:||.:..|..|.|.||.||||::||:|:||||.:||||
  Rat    70 PFLMGCGTKEPKVTQLCLAAIQRLMSHEVVSEAAAGNIINMLWQLMENSLEELKLLQTVLVLLTT 134

  Fly   136 NTVVHGDTLAKALVLCFRLHYAKNPTIVNTAGATIRQLVSLVFERVYLEKDSVSSLQQQQSSGSP 200
            |||||.:.|:||:|||||||:.|:....|||.||:||:|::||||:..|.|      :.:....|
  Rat   135 NTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDD------RHRDIDPP 193

  Fly   201 A--EGEGGNQDVQTF---ASDAFLLFQDLVQLVNADQPYWLLGMTEMTRTFGLELLEAVLTNFSA 260
            .  :|....:.|.|.   |.||::|||||.||||||.||||:|||||||||||||||:||.:|..
  Rat   194 VLIQGNSNRRSVSTLRPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQ 258

  Fly   261 VFHESNDFRLLLKERVCALVIKLFSPNVKHRQLPAPSNGNAPVPAEKPYFPISMRLLRLVAILIQ 325
            ||.:..:|..|||||||.|||||||||:|.||  .....::|.|.|||||||.|||||:|::||:
  Rat   259 VFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQ--GSGTSSSPAPVEKPYFPICMRLLRVVSVLIK 321

  Fly   326 KYHTILVTECEIFLSLIIKFLDPDKPAWQRALALEVIHKLVTRSSLIAFFCKSYDLKNHATNIVH 390
            :::::|||||||||||::||||.|||.|.||:|:|.||:|..:..|:..||:|||:|.|:|.:..
  Rat   322 QFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPRLLRSFCQSYDMKQHSTKVFR 386

  Fly   391 DMIAAMGSYIRYSLI-----NASAMLNGQQNGVANSLTAMSGSNQCG----------FMFRGAYL 440
            |::.|:||:|:...:     |.:|......|......:|.:.|...|          |.:|||::
  Rat   387 DIVNALGSFIQSLFLVPPTGNPAAANQAGNNNAGGPASAPANSGVVGIGAGVTLLPAFEYRGAWI 451

  Fly   441 PLVATYAPGVSKAVYLEMLDKIDASNIPDSYGISVGHAILLDMTRSI--------GGVIQRTPEL 497
            |::.....|.:||.|||||||::...||:.|.:||....|||:.|.|        |.|....|.:
  Rat   452 PILTITVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITTMIEGELGEVETECPTV 516

  Fly   498 ------HPSHNTAVITEEEH-------KPLCLQLVNSSWSALLSAFIPLVETSIDEATTENILKA 549
                  ..|......:|.:|       :.:..::|::.|..||:|...|::.|.|||.|||||||
  Rat   517 TEGASSQSSERRDEQSESDHMDQETVSRAVWEEMVSACWCGLLAALSLLLDASTDEAATENILKA 581

  Fly   550 MQNYAALCGMLEQLQPRDAFIMAMCRASFPPHYAMSIFANTTQSDGDLRCHTRSGSQDLSSQFIN 614
            ....|||||.|..:..|||||.|:|:.|.|||||:::...||.:....:.::..|.   |...|:
  Rat   582 ELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNATTAATLSNKSYSIQGQ---SVMMIS 643

  Fly   615 SCSGDAGDFRPQIVAVGTPLPSASLPHSVMQAPVMLTNKNLQCMRAILFLAHNNGGILGTSWHIV 679
            ..|    :...|:||||.||  |..|    |..||||:||:||||.:|.|||.:|.:|||||.:|
  Rat   644 PSS----ESHQQVVAVGQPL--AVQP----QGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLV 698

  Fly   680 LQTLQHLVWILGLKPSTGGSLQAMPKPAVEA-NVGIQTAVMADLPVLSQMLSQLFESSQYLDDVA 743
            |.||||||||||||||:||:|:  |..|||. :..:.||||.||||:|.:||:|||||||||||:
  Rat   699 LATLQHLVWILGLKPSSGGALK--PGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVS 761

  Fly   744 LHHLIDALCKLSHEAMELAYA-NREPSLFAVAKLLETGLVNMPRIKVLWRPLTNHLLE-VCQHRH 806
            |||||:|||.||.|||::||. |:||||||||||||||||||.||::||||||.|||| ||||.:
  Rat   762 LHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEKVCQHPN 826

  Fly   807 IRMREWGVEAITYLVKSALQFKHKTPLKENMELQTMLLSPLSELSTVLHADVRQRQLDCVLQILN 871
            .||||||.||:|.|:|:.|.|.|:.||.:|..||.:||:||.|:|.:.|.|:|.:||:||||||.
  Rat   827 SRMREWGAEALTSLIKAGLTFNHEPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQ 891

  Fly   872 TAGEILSFGWPAIIEIIGAVNEHHGEPLIRTAFQCLQLVITDFLTVMPWRCLPLCISTAAKFGSQ 936
            :.|:.|..|||.::.::||:....||.||||||||||||:||||..||..||.:.:..|..||..
  Rat   892 SQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCSCLQIVVDVAGSFGLH 956

  Fly   937 TQELNISLTAIGLMWNISDFFNQ----------NQDKLMSTQLQDVSI---LPDFPGTVKMPQFD 988
            .||||||||:|||:|||||:|.|          .::.....|.::..:   .|..|.    |.||
  Rat   957 NQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVSLNRPFHPA----PPFD 1017

  Fly   989 KLWMCLYAKLGELCVDLRPAVRKSAGQTLFSTISAHGSLLNPPTWQALVWQVLFPLLDNVRALSS 1053
            .||:||||||||||||.||||||||||||||||.|||:||...||..::|:|||.|||.||..|:
  Rat  1018 CLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHATWHTVIWKVLFHLLDRVRESST 1082

  Fly  1054 SASNEKVDA-SGNILIHHSRNTAQKQWAETQVLTLSGVCRVFNTKRELLQMLGDFERAWSLILEF 1117
            :|..||::: .|||||||||:||:||||||.||||:||.|:|||:|.|||.||||.|||.::|:.
  Rat  1083 TADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDH 1147

  Fly  1118 IQNAALSKNGEVSLAALKSLQEIMY---------------------------------------H 1143
            ||:||||||.|||||||||.|||:.                                       .
  Rat  1148 IQSAALSKNNEVSLAALKSFQEILQIVSPARDSEKPETPVGTVPVPVLIGNISGQGLSRPFVRTD 1212

  Fly  1144 NTAERTERALKDPQ--TAQEQDEEIWTIAWNIWLSIGMESTKMSTSTSAKLQQQNSNGAETQEDF 1206
            :..|:..|...:|.  |.:.:|.::|..|||.|...|.|||: ..||..:|.
  Rat  1213 SIGEKLGRCSSEPPVVTDEAEDLKLWWAAWNTWHRTGSESTE-PPSTFDELT------------- 1263

  Fly  1207 YIPSQAFLTALIQIFPAIFQHIQVKFTAADFDKFCTVLTNAVCIPVQTDAVPYIMSTVSDTLLTP 1271
            :||||.|||||||||||::|||:..|:.||..|...:|.:||.:|:.:||.|:|:.:.::.:||.
  Rat  1264 FIPSQPFLTALIQIFPALYQHIKAGFSMADLQKLGVILHSAVSVPISSDASPFILPSYTEAVLTS 1328

  Fly  1272 LHDGILDCMELIQKEATKPDSHISQLIPAIFRQLLIFSKFACAPPTFQQSVEHKYAKSSGHYANN 1336
            |.:.:|..::::||.......::..:.||||.|||.|.:|:|.||.:.| :|.|:..::.|  |.
  Rat  1329 LQEAVLTALDVLQKAICVGPENMQIMYPAIFEQLLAFVEFSCKPPQYGQ-LETKHIANAKH--NQ 1390

  Fly  1337 ----ASVEVVSMNYIPFGEKSISICVKLYQTTATEDSVVQEQILHDIVKALRTPLAMKYKCLSSS 1397
                |..|.|::||:||.|:|:.:.|.|||.||...:||.|::|..|:|.||.||::||.|.|.|
  Rat  1391 IQLFAPAEWVALNYVPFAERSLEVVVDLYQKTACHKAVVNEKVLQSIIKTLRVPLSLKYSCPSES 1455

  Fly  1398 TWKLAISSLISVLHTGLKVARAKPQH-----FASLWDDLADTLDKFLFPASVCTIEDRGLEEIVL 1457
            |||||::||:.||..||.|||   ||     |.|:|.:||.||:.|||..|: ..::..::|...
  Rat  1456 TWKLAVASLLKVLSIGLPVAR---QHASSGKFDSMWPELASTLEDFLFTKSI-PPDNLSIQEFQR 1516

  Fly  1458 DETIDCQVIELLRDEVLPHSHEMPHQFIMQIVVLLNKGSIHSASDTNICYESDWKLREIFAKTCF 1522
            :|:||.:|::|:..|:||:::.:|..|:.|::.:||:|||||...:....|.|.:|||.|:|.||
  Rat  1517 NESIDVEVVQLISAEILPYANLIPKAFVAQMMTMLNRGSIHSQPSSFTEAEIDIRLREEFSKMCF 1581

  Fly  1523 ETLLQFSLLEDHANTNNNRLNANVLTAGAAGAGGKDFAGRLAVTALLHRFQEVLKRFNDDERQSG 1587
            |||||||.             :|.:|....|     :..|:|::.||.|.|:||.|:.:|||.||
  Rat  1582 ETLLQFSF-------------SNKVTTPQEG-----YISRMALSVLLKRSQDVLHRYIEDERLSG 1628

  Fly  1588 KCPLPRFRLSEISFVLKAIATLVVSMKKAPASKVNKPAWDQLIGLYPYLVDCTTTTSPEVSRSLR 1652
            ||||||.:::||.|||||::||:.|:||.....|:...|.|:|.|||.||:|.|.:|.:|..:|:
  Rat  1629 KCPLPRQQVTEIIFVLKAVSTLIDSLKKTQPENVDGNTWAQVIALYPTLVECITCSSSDVCSALK 1693

  Fly  1653 EALLQYTDLLQAPRS 1667
            |||:.:.|.:|.|.|
  Rat  1694 EALVPFKDFMQPPAS 1708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mon2	NP_001033884.2	DCB	13..184	CDD:292830	83/177 (47%)
		Sec7_N	213..380	CDD:289549	105/169 (62%)
		DUF1981	827..909	CDD:286414	42/81 (52%)
		Mon2_C	912..1665	CDD:292823	360/816 (44%)
Mon2	XP_038935067.1	DCB	9..180	CDD:406594	82/174 (47%)
		Sec7_N	211..380	CDD:403860	108/170 (64%)
		DUF1981	<870..929	CDD:401312	30/58 (52%)
		Mon2_C	932..1706	CDD:374431	360/816 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349347
Domainoid	1	1.000	635	1.000	Domainoid score	I162
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44309
Inparanoid	1	1.050	1475	1.000	Inparanoid score	I101
OMA	1	1.010	-	-		QHG55736
OrthoDB	1	1.010	-	-		D411011at2759
OrthoFinder	1	1.000	-	-		FOG0004981
OrthoInspector	1	1.000	-	-		oto98441
orthoMCL	1	0.900	-	-		OOG6_102916
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3515
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910