Protein Alignment mon2 and mon-2

DIOPT Version :9

• Sequence 1: NP_001033884.2
• Gene: mon2 / 326157
• FlyBaseID: FBgn0031985
• Length: 1684
• Species: Drosophila melanogaster
• Sequence 2: NP_001255623.1
• Gene: mon-2 / 178153
• WormBaseID: WBGene00008685
• Length: 1648
• Species: Caenorhabditis elegans
• Alignment Length: 1720
• Identity: 549/1720 - (31%)
• Similarity: 905/1720 - (52%)
• Gaps: 161/1720 - (9%)

  Fly    13 DVHKFVEALQADFKTLSLETKKKYPQIKEACEEAISKLCTAGSSQQNSVYYTVN------QILYP 71
            |..|.||||..|.:.||.|.|||...:|||.|..:.::....::.........|      ::|:|
 Worm     7 DSKKLVEALLGDLRLLSQEAKKKQNHVKEAAESGVVRIRNISTASVGDTVLITNLRAACTELLHP 71

  Fly    72 LVQGCETKDLKIIKFCLGMMQRLITQQVVDQKGALYITNALWTLMENNIEEVKVLQTVTLLLTTN 136
            ||..|||:..::::..|..:|||:..:::.|.||..:||.||:|:|...||::|||||..|:::.
 Worm    72 LVLSCETRHTRLVQIALQGIQRLVQHRILSQNGATIVTNELWSLVEAECEELRVLQTVPPLVSSE 136

  Fly   137 TVVHGDTLAKALVLCFRLHYAKNPTIVNTAGATIRQLVSLVFERVYLEKDSVSSLQ---QQQSSG 198
            .:|.|:||||.:|:|||||:||:|.::|.|.|.:|||||.||||| :::|.:.|.:   ...|.|
 Worm   137 LIVTGNTLAKCIVMCFRLHFAKDPIVINAASAAVRQLVSTVFERV-IQEDGIFSTELTVVNPSGG 200

  Fly   199 SPAEGEGGNQDVQTFASDAFLLFQDLVQLVNADQPYWLLGMTEMTRTFGLELLEAVLTNFSAVFH 263
            .|:. ......::..|:||::||:||..|:|.:.|.||:|:.|.|||.||||||::|..|.:||.
 Worm   201 RPSP-RAAPPTLRPCAADAYMLFKDLCLLINGEAPIWLVGIQETTRTLGLELLESLLKGFPSVFI 264

  Fly   264 ESNDFRLLLKERVCALVIKLFSPNVK----HRQLPAPSNGNA-------PVPAEKPYFPISMRLL 317
            ...:|..|||:.||.|:|:|||||||    ..|.|:....||       .:..|:..|||||||:
 Worm   265 RHTEFGDLLKDDVCPLIIRLFSPNVKAMHISSQHPSSRTSNASFNNYPPTISHERQSFPISMRLV 329

  Fly   318 RLVAILIQKYHTILVTECEIFLSLIIKFLDPDKPAWQRALALEVIHKLVTRSSLIAFFCKSYDLK 382
            |:|.:::|.|.|||.||||||:|.::||:|.|:..|||.||||.:|::|:.:.|:.:..:|:|.:
 Worm   330 RIVTLIVQFYQTILHTECEIFISTLLKFVDGDRKGWQRPLALESLHRIVSSTDLVKWMTESFDCR 394

  Fly   383 NHATNIVHDMIAAMGSYIRYSLINASAMLNGQQNGVANSLTAMSGSNQCGFMFRGAYLPLVATYA 447
            .::|:::..:...:.:.::..|: .:...:.|:|.:..|    ......||:.:|.::|.|....
 Worm   395 PNSTHVLEQVAIGLSTVVQQCLV-CTTFSSDQENEIDRS----QEDGGPGFLSKGLWVPYVEHLT 454

  Fly   448 PGVSKAVYLEMLDKIDASNIPDSYGISVGHAILLDMTRSIGGVIQRTPELHPSHNTAVITEEEHK 512
            .  .|.:.|:.||::||..||:.|.:|.....|.|||:::...|.:...:  ..|:...:.|...
 Worm   455 S--KKTILLDSLDRMDAVAIPEGYVLSRCCVALCDMTQAVYAAIDKLCLV--DENSEAGSSETKL 515

  Fly   513 PLCLQLVNSSWSALLSAFIPLVETSIDEATTENILKAMQN-YAALC--GMLEQLQPRDAFIMAMC 574
            .:......:|..::|:|...|:..|.||..::.:|..:.. .:|.|  |....|. |..:::|:
 Worm   516 EIAKVAYANSQPSILAAIGSLLAASTDEIVSDQLLCCLSTLISAGCRVGADADLH-RSVYVLAI- 578

  Fly   575 RASFP-PHYAMSIFANTTQSDGDLRCHTRSGSQDLSSQFINSCSGDAGDFRPQIVAVGTPLPSAS 638
             .|.| |.|..........|..:.|      ...:|.|..:.   :|.....|:.|.|.|.|...
 Worm   579 -MSLPSPSYLNQFAGIAPPSPANKR------DAPVSEQVFDL---EAWPSTTQVTASGPPCPCPV 633

  Fly   639 LPHSVMQAPVMLTNKNLQCMRAILFLAHNNGGILGTSWHIVLQTLQHLVWILGLKPSTGGSLQAM 703
            :...:....|:||:||||..|..:.....:...|...|::.:.|.:||.|:|.::|:..|..:..
 Worm   634 VSTELWNKQVLLTSKNLQAARTFIASITTHIKELNNLWYLCMATCEHLSWLLAMRPTQVGQFERE 698

  Fly   704 PK------PAVEANVGIQTAVMADLPVLSQMLSQLFESSQYLDDVALHHLIDALCKLSHEAMELA 762
            .:      |.|..|     |.::|:.:||.::.::..:...|.|.:...:||||.:||.|::.:|
 Worm   699 TRDDHSNVPTVVTN-----AALSDIAMLSSLMDKVAPAIAALPDKSFLSVIDALIRLSDESLAVA 758

  Fly   763 YANREPSLFAVAKLLETGLVNMPRIKVLWRPLTNHLLEVCQHRHIRMREWGVEAITYLVKSALQF 827
            ...||.|||.:|.|.:...:::.|::|.|:...||.::||.|..:.||:|...|:|.|.|.|::.
 Worm   759 ATGRESSLFPLAVLYKVCSLSLMRLQVFWQKAANHFIKVCNHTSVSMRDWAAVALTSLAKHAVKS 823

  Fly   828 KHKTPLKENMELQTMLLSPLSELSTVLHADVRQRQLDCVLQILNTAGE-ILSFGWPAIIEIIGAV 891
            |.....|...|   |::|.|..|.::.|..||:||||||:.::.|.|. :||..||.:|:||.|:
 Worm   824 KTSMDAKSQQE---MIISSLLALCSIPHIQVRRRQLDCVMSLMQTDGAFLLSTSWPNVIQIISAI 885

  Fly   892 NEHHGE---PLIRTAFQCLQLVITDFLTVMPWRCLPLCISTAAKFGSQTQELNISLTAIGLMWNI 953
            .:...|   .|:|..:..|:||.:|||..:|:.|:...:...:::..|..:.||||:|:.|:|.|
 Worm   886 IDSDTECELSLVRQGYLGLRLVSSDFLQSIPFDCISGLVEAISRYSKQNTDQNISLSALTLLWTI 950

  Fly   954 SDFFNQNQDKLMSTQLQDVSILPDFPGTVKMPQFDKLWMCLYAKLGELCVDLRPAVRKSAGQTLF 1018
            |||..:..:.:.:    |.|              :.:||.||..|.|.|||.|.||||||.|||.
 Worm   951 SDFIYRKMESVGN----DAS--------------EAVWMVLYTCLSESCVDSRFAVRKSACQTLL 997

  Fly  1019 STISAHGSLLNPPTWQALVWQVLFPLLDNVRALSSSASNEKVDASGNILIHHSRNTAQKQWAETQ 1083
            .|::|||..|....|.:::||::.||||.||:.:..||.||  ::|.:::||||:|.||||.||.
 Worm   998 QTVTAHGHALRSAAWHSVIWQIMIPLLDKVRSQTRCASTEK--SNGELIMHHSRDTEQKQWTETC 1060

  Fly  1084 VLTLSGVCRVFNTKRELLQMLGDFERAWSLILEFIQNAALSKNGEVSLAALKSLQEIMY------ 1142
            :.|:|.:.::||::|:.|..|.||...|...|.::..||..:|.|:||:|::|.||::.
 Worm  1061 IHTISAISKIFNSQRKSLLALNDFGAVWEAFLGYLDWAACYENAELSLSAIRSYQEVLLGKISSQ 1125

  Fly  1143 ---------HNTAERTERALKDPQTAQEQDEEIWTIAWNIWLSI--------------GMESTKM 1184
                     .|.::.|..|: .|:..|.|    |..:|.:||.|              .:.:...
 Worm  1126 TLNVNSHEKSNGSDSTIDAI-TPELPQAQ----WVESWKVWLRISRGLARQGCAAMANSVNADSK 1185

  Fly  1185 STSTSAKLQQQNSNGAETQEDFYIPSQAFLTALIQIFPAIFQHIQVKFTAAD--FDKFCTVLTNA 1247
            |.|::.::...:|:.|......|:|..:.|||::.:||.:|..:....|..|  ::....||.:.
 Worm  1186 SISSTPRMNSSSSSLASLAPGIYVPGPSHLTAILHVFPPLFDKVAKSITVDDLKYESLPAVLESM 1250

  Fly  1248 VCIPVQTDAVPYIMSTVSDTLLTPLHDGILDCMELIQKEATKPDSHISQLIPAIFRQLLIFSKFA 1312
            :.:|:.::..|:::.:.: |.|||..:.:|:.::::..|.|...:.:...||...|.||.|:..|
 Worm  1251 MNVPIPSEQAPFVLPSAT-THLTPTQEALLEAVKIVFVECTLSGTSLRAAIPDQIRLLLKFASMA 1314

  Fly  1313 CAPPTFQQSVEHKYA----KSSGHYANNASVEVVSMNYIPFGEKSISICVKLYQTTATEDSVVQE 1373
            .     |:...:|.|    ||...||        ....:||.|.|:.|.::.:.:|:....|...
 Worm  1315 T-----QRISPNKVAPGGQKSYRDYA--------LTTIVPFSEYSLRIAIEFFTSTSQNPEVANS 1366

  Fly  1374 QILHDIVKALRTPLAMKYKCLSSSTWKLAISSLISVLHTGLKVARAKPQHFASLWDDLADTLDKF 1438
            .|..||:|.|..||.|||.|:|:||||||.:||:|||.|.:..||..|:.|..||..:.||::::
 Worm  1367 LIAIDIIKFLGEPLYMKYTCISASTWKLAATSLMSVLRTSIPYARQNPEVFRGLWSAICDTMERW 1431

  Fly  1439 LFPASVCTIEDRGLEEIVLDETIDCQVIELLRDEVLPHSHEMPHQFIMQIVVLLNKGSIHSASDT 1503
            ||..:..|  ....:|...||.::||.||::|.|:|.::..:|.:.:.:::.||::|||.....|
 Worm  1432 LFTPNKST--RLAADERKRDELMECQAIEIIRSEMLAYASRLPQEDVQRLIALLHRGSISQIDST 1494

  Fly  1504 NICYESDWKLREIFAKTCFETLLQFSLLEDHANTNNNRLNANVLTAGAAGAGGKDFAGRLAVTAL 1568
            ::........|...||.||:.||..|   |.|:||...            ..|:...|.:|||:|
 Worm  1495 DVLASDSHTQRNELAKACFDALLMSS---DGAHTNTEE------------DEGRGILGNVAVTSL 1544

  Fly  1569 LHRFQEVLKRFNDDERQSGKCPLPRFRLSEISFVLKAIATLVVSMKKAPASKVNKPAWDQLIGLY 1633
            |.|..:|:..|..|...:|...|||.|:.||...|:|:.:|:..:.:.|  |:.: .:..|:.|:
 Worm  1545 LQRCTQVMSDFCKDWSAAGDLRLPRSRILEIISALQAVDSLIARLARDP--KMTE-LYSHLVSLF 1606

  Fly  1634 PYLVDCTTT--TSPEVSRSLREALLQYTDL 1661
            |.:||....  ..|::...|.:.:..|..|
 Worm  1607 PSVVDVMPCCHADPQLEHQLIKTIKSYQTL 1636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mon2	NP_001033884.2	DCB	13..184	CDD:292830	74/176 (42%)
		Sec7_N	213..380	CDD:289549	83/177 (47%)
		DUF1981	827..909	CDD:286414	30/85 (35%)
		Mon2_C	912..1665	CDD:292823	242/787 (31%)
mon-2	NP_001255623.1	DCB	7..184	CDD:292830	74/177 (42%)
		Sec7_N	214..395	CDD:289549	84/180 (47%)
		DUF1981	833..901	CDD:286414	27/70 (39%)
		Mon2_C	909..1615	CDD:292823	238/764 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160399
Domainoid	1	1.000	380	1.000	Domainoid score	I446
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44309
Inparanoid	1	1.050	862	1.000	Inparanoid score	I211
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55736
OrthoDB	1	1.010	-	-		D411011at2759
OrthoFinder	1	1.000	-	-		FOG0004981
OrthoInspector	1	1.000	-	-		oto18597
orthoMCL	1	0.900	-	-		OOG6_102916
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R733
SonicParanoid	1	1.000	-	-		X3515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940