DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mon2 and mon2

DIOPT Version :9

Sequence 1:	NP_001033884.2	Gene:	mon2 / 326157	FlyBaseID:	FBgn0031985	Length:	1684	Species:	Drosophila melanogaster
Sequence 2:	XP_031754733.1	Gene:	mon2 / 100489029	XenbaseID:	XB-GENE-975876	Length:	1745	Species:	Xenopus tropicalis

Alignment Length:	1804	Identity:	844/1804 - (46%)
Similarity:	1129/1804 - (62%)	Gaps:	229/1804 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VHKFVEALQADFKTLSLETKKKYPQIKEACEEAISKLCTAGSS--------QQNSVYYTVNQILY 70
            :.|.::.:|:|.:.||:|.|||:|.:|||.|..|.|:....:.        ::||     ::::.
Frog    13 IKKLLDNMQSDLRGLSMECKKKFPPVKEAAESGIVKVKNIAARSPDILTALKENS-----SEVVQ 72

  Fly    71 PLVQGCETKDLKIIKFCLGMMQRLITQQVVDQKGALYITNALWTLMENNIEEVKVLQTVTLLLTT 135
            |.:.||.||:.||.:.||..:|||::.:||.:..|..|.|.||.||||.:||:|:||||.:||||
Frog    73 PFLMGCGTKEPKITQLCLAAIQRLMSHEVVSEGAAGNIINMLWQLMENGLEELKLLQTVLVLLTT 137

  Fly   136 NTVVHGDTLAKALVLCFRLHYAKNPTIVNTAGATIRQLVSLVFERVYLE----KDSVSSLQQQQS 196
            |||||.::|:||:|||||||:.|:....|||.||:||:|::||||:..|    ||:|       .
Frog   138 NTVVHDESLSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHKDAV-------E 195

  Fly   197 SGSPAEGEGGNQDVQTF---ASDAFLLFQDLVQLVNADQPYWLLGMTEMTRTFGLELLEAVLTNF 258
            ...|..|....:.|.|.   |.||::|||||.||||||.||||:|||||||||||||||:||.:|
Frog   196 QPVPVIGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDF 260

  Fly   259 SAVFHESNDFRLLLKERVCALVIKLFSPNVKHRQLPAPSNGNA-PVPAEKPYFPISMRLLRLVAI 322
            ..||.:..:|..|||||||.|||||||||:|.||   .||.|| |.|.|||||||.|||||:|::
Frog   261 PQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQ---GSNSNASPAPVEKPYFPICMRLLRVVSV 322

  Fly   323 LIQKYHTILVTECEIFLSLIIKFLDPDKPAWQRALALEVIHKLVTRSSLIAFFCKSYDLKNHATN 387
            ||::::::|||||||||||::||||.|||.|.||:|:|.||:|..:..|:..||:|||:|.|:|.
Frog   323 LIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTK 387

  Fly   388 IVHDMIAAMGSYIRYSLINASA-------------MLNG------------QQNGVANSLTAMSG 427
            :..|::.|:||:|:...:..||             :|||            .|.|.:.|:|..|.
Frog   388 VFRDIVNALGSFIQSLFLIPSAGPASTTTNPPAAHLLNGGIVLLLQMEKAVVQAGGSTSITPASN 452

  Fly   428 SNQCG-------------FMFRGAYLPLVATYAPGVSKAVYLEMLDKIDASNIPDSYGISVGHAI 479
            ....|             |.:||.::|::.....|.:||.|||||||::...||:.|.:||....
Frog   453 QTTSGMAAATSNTTVLPAFEYRGTWIPILTISIQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHC 517

  Fly   480 LLDMTRSIGGVIQ------------RTPELHPSHNTA------VITEEEHK-PLCL----QLVNS 521
            |||:.|.|..:|:            ...|..|:..|:      |:::...| |.|.    :::|:
Frog   518 LLDLVRGITTMIEGEIGQAETDSHISAEETRPNAPTSDQQDLPVVSDPSDKDPGCRSVWEEMINA 582

  Fly   522 SWSALLSAFIPLVETSIDEATTENILKAMQNYAALCGMLEQLQPRDAFIMAMCRASFPPHYAMSI 586
            .|..||:|...|::.|.||..|||||||....|||||.|..:.||||.|.|:|:.|.|||||:::
Frog   583 CWCGLLAALSLLLDASTDETATENILKAEMTMAALCGKLGLVTPRDALITAICKGSLPPHYALTV 647

  Fly   587 FANTTQSDGDLRCHTRSGSQDLSSQFINSCSGDAGDFRPQIVAVGTPLPSASLPHSVMQAPVMLT 651
            . ||:.:   ..|:.....|..:.|.|:..|    |...|:||||.||  |..|    |..||||
Frog   648 L-NTSSA---AICNKSYSIQGQNVQMISPSS----DSHQQVVAVGQPL--AVQP----QGTVMLT 698

  Fly   652 NKNLQCMRAILFLAHNNGGILGTSWHIVLQTLQHLVWILGLKPSTGGSLQAMPKPAVEA-NVGIQ 715
            .||:||||.:|.|||.:||.|||||.:||.||||||||||||||:||:|:  |..|||. :..:.
Frog   699 AKNIQCMRTLLNLAHCHGGYLGTSWQLVLATLQHLVWILGLKPSSGGALK--PGRAVEGPSTVLT 761

  Fly   716 TAVMADLPVLSQMLSQLFESSQYLDDVALHHLIDALCKLSHEAMELAYA-NREPSLFAVAKLLET 779
            ||||.|||::|.:||:|||||||||||:|||||:|||.||.|||::||. |:|||||||||||||
Frog   762 TAVMTDLPIISTILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLET 826

  Fly   780 GLVNMPRIKVLWRPLTNHLLE-VCQHRHIRMREWGVEAITYLVKSALQFKHKTPLKENMELQTML 843
            |||||.||::||||||.||:| ||||.:.||||||.||:|.|:|:.|.|||:..|.||..||.:|
Frog   827 GLVNMHRIEILWRPLTGHLIEKVCQHPNARMREWGAEALTSLIKAGLAFKHEPQLSENQRLQLLL 891

  Fly   844 LSPLSELSTVLHADVRQRQLDCVLQILNTAGEILSFGWPAIIEIIGAVNEHHGEPLIRTAFQCLQ 908
            |:||.|||.::|.|:|.:||:||||||.:.|:.|..|||.::.:|||:....||.|||.||||||
Frog   892 LNPLKELSNIIHHDIRLKQLECVLQILQSQGDSLGPGWPLVLGVIGAIRNDQGESLIRNAFQCLQ 956

  Fly   909 LVITDFLTVMPWRCLPLCISTAAKFGSQTQELNISLTAIGLMWNISDFFNQ----------NQDK 963
            ||:||||..||..||.:.:..|..||.|.||||||||:|||:|||||:|.|          .::.
Frog   957 LVVTDFLPTMPCTCLQIVVEVAGSFGLQNQELNISLTSIGLLWNISDYFYQRGESIEKELNREED 1021

  Fly   964 LMSTQLQDVSIL---PDFPGTVKMPQFDKLWMCLYAKLGELCVDLRPAVRKSAGQTLFSTISAHG 1025
            |:..|.::..|.   |..|.    |.||.||:||||||||||||.||||||||||||||||.|||
Frog  1022 LLQKQAKEKGITLNRPFHPA----PPFDCLWLCLYAKLGELCVDTRPAVRKSAGQTLFSTIGAHG 1082

  Fly  1026 SLLNPPTWQALVWQVLFPLLDNVRALSSSASNEKVDA-SGNILIHHSRNTAQKQWAETQVLTLSG 1089
            :||...||..::|:|||.||:.||..|::|..||::: .|||||||||:||:||||||.||||:|
Frog  1083 TLLQHATWHTVIWKVLFQLLNQVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAG 1147

  Fly  1090 VCRVFNTKRELLQMLGDFERAWSLILEFIQNAALSKNGEVSLAALKSLQEIMY------------ 1142
            |.|:|||:|.|||.||||.:||.::|:.||:||||||.|||||||||.|||:.
Frog  1148 VARIFNTRRYLLQPLGDFSKAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPTRDMDKPE 1212

  Fly  1143 ---------------------------HNTAERTER--ALKDPQTAQE-QDEEIWTIAWNIWLSI 1177
                                       .:|.||..|  ..:.|.|..| :|..:|..|||.|..|
Frog  1213 SLPGISVPVPVLIGPVASGLGRPLVRADSTGERLSRYSIPEQPITVDEIEDASLWWAAWNTWYRI 1277

  Fly  1178 GMESTKMSTSTSAKLQQQNSNGAETQEDFYIPSQAFLTALIQIFPAIFQHIQVKFTAADFDKFCT 1242
            |.|||| ...|..||.             :||||.|||||||||||::|||:..|:..|..|...
Frog  1278 GTESTK-PPITCDKLT-------------FIPSQPFLTALIQIFPALYQHIKTAFSMDDLQKLGV 1328

  Fly  1243 VLTNAVCIPVQTDAVPYIMSTVSDTLLTPLHDGILDCMELIQKEATKPDSHISQLIPAIFRQLLI 1307
            :|..||.:|:.:||.|:|:.:.::.:||.|.:.:|..::::||.......::..:.||||.||..
Frog  1329 ILHGAVSVPISSDASPFILPSYTEAVLTSLQESVLTALDVLQKAICVGPENMQSMYPAIFNQLSA 1393

  Fly  1308 FSKFACAPPTFQQSVEHKYAK-SSGHYANN--------ASVEVVSMNYIPFGEKSISICVKLYQT 1363
            |.:|:|.||        :|.| .:.|.||.        |..|.|::||:||.|||:.:.|.|||.
Frog  1394 FVQFSCKPP--------QYGKLETKHIANAKYNQIQLFAPAEWVALNYVPFAEKSLEVMVDLYQK 1450

  Fly  1364 TATEDSVVQEQILHDIVKALRTPLAMKYKCLSSSTWKLAISSLISVLHTGLKVARAKPQH----- 1423
            ||...:||.|::|.:::|.||.||::||.|.|.||||||:|||:.||..||.|||   ||
Frog  1451 TACHKAVVNEKVLQNVIKTLRVPLSLKYACPSESTWKLAVSSLLKVLSVGLPVAR---QHASSGK 1512

  Fly  1424 FASLWDDLADTLDKFLFPASVCTIEDRGLEEIVLDETIDCQVIELLRDEVLPHSHEMPHQFIMQI 1488
            |.|:|.:||.|.:.|||..|. ..::..:||...:|:||.:|::|:..|:||:::.:|..|:.:|
Frog  1513 FDSMWPELACTFEDFLFTKST-PPDNLSIEEFQRNESIDVEVVQLISTEILPYANFIPKDFVGKI 1576

  Fly  1489 VVLLNKGSIHSASDTNICYESDWKLREIFAKTCFETLLQFSLLEDHANTNNNRLNANVLTAGAAG 1553
            :.:||||||||.|.:....|.|.::||.|:|.|||||||||.             :|.:|....|
Frog  1577 MTMLNKGSIHSQSSSFTEAEIDIRMREEFSKVCFETLLQFSF-------------SNKVTTPQEG 1628

  Fly  1554 AGGKDFAGRLAVTALLHRFQEVLKRFNDDERQSGKCPLPRFRLSEISFVLKAIATLVVSMKKAPA 1618
                 :..|:|::.||.|.|:||.|:.:||:.||||||||.|::||.|||||::||:.|:||...
Frog  1629 -----YISRMALSVLLKRSQDVLHRYIEDEKLSGKCPLPRQRVTEIIFVLKAVSTLIDSLKKTHP 1688

  Fly  1619 SKVNKPAWDQLIGLYPYLVDCTTTTSPEVSRSLREALLQYTDLLQAPRS 1667
            ..|:...|.|:|.|||.||:|.|.:|.||..:|:|||:.:.|.:..|.|
Frog  1689 ENVDANTWAQVISLYPTLVECITCSSSEVCTALKEALVPFKDFMHPPAS 1737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mon2	NP_001033884.2	DCB	13..184	CDD:292830	80/177 (45%)
		Sec7_N	213..380	CDD:289549	109/170 (64%)
		DUF1981	827..909	CDD:286414	44/81 (54%)
		Mon2_C	912..1665	CDD:292823	366/822 (45%)
mon2	XP_031754733.1	DCB	12..183	CDD:406594	80/177 (45%)
		Sec7_N	215..384	CDD:403860	111/169 (66%)
		DUF1981	<899..957	CDD:401312	38/57 (67%)
		Mon2_C	960..1735	CDD:374431	338/767 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	637	1.000	Domainoid score	I169
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H44309
Inparanoid	1	1.050	1475	1.000	Inparanoid score	I110
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D411011at2759
OrthoFinder	1	1.000	-	-		FOG0004981
OrthoInspector	1	1.000	-	-		oto105132
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3515
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160