Protein Alignment mon2 and mon2

DIOPT Version :9

• Sequence 1: NP_001033884.2
• Gene: mon2 / 326157
• FlyBaseID: FBgn0031985
• Length: 1684
• Species: Drosophila melanogaster
• Sequence 2: XP_021326251.1
• Gene: mon2 / 100334806
• ZFINID: ZDB-GENE-030131-2712
• Length: 1712
• Species: Danio rerio
• Alignment Length: 1765
• Identity: 831/1765 - (47%)
• Similarity: 1130/1765 - (64%)
• Gaps: 183/1765 - (10%)

  Fly    14 VHKFVEALQADFKTLSLETKKKYPQIKEACEEAISKLCTAGSS--------QQNSVYYTVNQILY 70
            |.|.:|.:|||.::||:|.|||:|.:|||.|..|.|:.|..:.        ::||     ::::.
Zfish    13 VKKLLENMQADLRSLSMECKKKFPPVKEAAESGIVKIKTIAARNTDILAALKENS-----SEVVQ 72

  Fly    71 PLVQGCETKDLKIIKFCLGMMQRLITQQVVDQKGALYITNALWTLMENNIEEVKVLQTVTLLLTT 135
            |.:.||.||:.||.:.||..:|||::.:||.:..|..|.|.||.||||.:||:|:||||.:||||
Zfish    73 PFLMGCGTKEPKITQLCLAAIQRLMSHEVVSEAAAGNIINMLWQLMENGLEELKLLQTVLVLLTT 137

  Fly   136 NTVVHGDTLAKALVLCFRLHYAKNPTIVNTAGATIRQLVSLVFERVYLEKDSVSSLQQQQSSGSP 200
            ||:||.:.|:||:|||||||:.|:....|||.||:||:|::||||:..|.:....|.::    .|
Zfish   138 NTIVHDEVLSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERFKGLNEE----PP 198

  Fly   201 A-EGEGGNQDVQTF---ASDAFLLFQDLVQLVNADQPYWLLGMTEMTRTFGLELLEAVLTNFSAV 261
            | :|....:.|.|.   |.||::|||||.||||||.||||:|||||||||||||||:||.:|..|
Zfish   199 AVQGNCNRRSVSTLRPSAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQV 263

  Fly   262 FHESNDFRLLLKERVCALVIKLFSPNVKHRQLPAPSNGNAPVPAEKPYFPISMRLLRLVAILIQK 326
            |.:..:|..|||||||.|||||||||:|.|| .:.|:..:|.|.|||||||.|||||:|::||:.
Zfish   264 FLQHQEFSFLLKERVCPLVIKLFSPNIKFRQ-GSSSSSASPAPVEKPYFPICMRLLRVVSVLIKH 327

  Fly   327 YHTILVTECEIFLSLIIKFLDPDKPAWQRALALEVIHKLVTRSSLIAFFCKSYDLKNHATNIVHD 391
            ::::|||||||||||::||||.:||.|.||:|:|.:|:|..:..|:..||:|||:|.|:|.:..|
Zfish   328 FYSLLVTECEIFLSLLVKFLDGEKPQWLRAVAVESVHRLCVQPHLLRSFCQSYDMKPHSTKVFRD 392

  Fly   392 MIAAMGSYIRYSLINASA-------------MLNGQQNGVAN-SLTAMSG--SNQCGFMFRGAYL 440
            ::.|:||:|:...|..||             :.:.|.:|... .||...|  :.|..|.:||.::
Zfish   393 IVNALGSFIQSLFILPSAGNTSSTSTPAGGSVSSSQASGPGGPGLTGAGGALTTQAAFEYRGTWI 457

  Fly   441 PLVATYAPGVSKAVYLEMLDKIDASNIPDSYGISVGHAILLDMTRSIGGVIQRTPELHPSHNTAV 505
            ||:.....|.:||.|||||||::..:||:.|.:||..:.|||:.|.|..:|.|  ||........
Zfish   458 PLMNVSVQGSAKATYLEMLDKVEPPSIPEGYAMSVAFSALLDLVRGITNMIDR--ELLRQEQQEA 520

  Fly   506 ITEEE-------HKPLCL----QLVNSSWSALLSAFIPLVETSIDEATTENILKAMQNYAALCGM 559
            :.|||       .:||..    ::||:.|..||:|...|::.|.||..|||||||..:.|:|||.
Zfish   521 MREEEEPVSPPAQEPLAAEVWQEMVNACWCGLLAALSLLLDASTDETATENILKAELSMASLCGR 585

  Fly   560 LEQLQPRDAFIMAMCRASFPPHYAMSIFANTTQSDGDLRCHTRSGSQDLSSQFINSCSGDAGDFR 624
            |..:.||||||.|:|:||.|||||::|.:::..|..: :.::..|.   |.|.::..|    :..
Zfish   586 LGLVTPRDAFITAVCKASLPPHYALTILSSSASSLTN-KVYSIQGQ---SVQMVSPSS----ESH 642

  Fly   625 PQIVAVGTPLPSASLPHSVMQAPVMLTNKNLQCMRAILFLAHNNGGILGTSWHIVLQTLQHLVWI 689
            .|:||||.||.:..      |..|:||.||:||||.:|.|||.:|..|||||.:||.||||||||
Zfish   643 QQVVAVGQPLSAQP------QGTVVLTAKNIQCMRTLLNLAHCHGAHLGTSWQLVLATLQHLVWI 701

  Fly   690 LGLKPSTGGSLQAMPKPAVEA-NVGIQTAVMADLPVLSQMLSQLFESSQYLDDVALHHLIDALCK 753
            |||||:.||.|:  |..|||. :..:.||||.||||:|.:||:|||||||||||:|||||:|||.
Zfish   702 LGLKPAPGGVLK--PGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCS 764

  Fly   754 LSHEAMELAY-ANREPSLFAVAKLLETGLVNMPRIKVLWRPLTNHLLE-VCQHRHIRMREWGVEA 816
            ||.||||:|| .|:||||||||||||||||||.||::||||||.|||| ||||.:.||||||.||
Zfish   765 LSMEAMEMAYGTNKEPSLFAVAKLLETGLVNMDRIEILWRPLTAHLLEKVCQHPNARMREWGAEA 829

  Fly   817 ITYLVKSALQFKHKTPLKENMELQTMLLSPLSELSTVLHADVRQRQLDCVLQILNTAGEILSFGW 881
            ||.|:|:.|.:||..||.:|..||.:||:||.|||.|||||:||:||:||||||...|:.|..||
Zfish   830 ITSLIKAGLSYKHDPPLSQNQRLQLLLLNPLKELSNVLHADIRQKQLECVLQILQNQGDSLGPGW 894

  Fly   882 PAIIEIIGAVNEHHGEPLIRTAFQCLQLVITDFLTVMPWRCLPLCISTAAKFGSQTQELNISLTA 946
            |.::.:|||:....||.||||||||||||:||||..||..||.:.:..|..||.|.||||||||:
Zfish   895 PLVLGVIGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCMCLQIVVDVAGSFGLQNQELNISLTS 959

  Fly   947 IGLMWNISDFFNQNQDKLMSTQLQDVSIL-------------PDFPGTVKMPQFDKLWMCLYAKL 998
            |||:|||||:|.|..:.:.....::.::|             |..|.    |.||.||:||||||
Zfish   960 IGLLWNISDYFFQRGEAITEELDKEEAVLLKQAQDKGEPLNRPFHPA----PPFDCLWLCLYAKL 1020

  Fly   999 GELCVDLRPAVRKSAGQTLFSTISAHGSLLNPPTWQALVWQVLFPLLDNVRALSSSASNEKVDA- 1062
            ||||||.|||||||||||:||||:|||:||.||||..:||:|||.|||.||..|::|..||:::
Zfish  1021 GELCVDPRPAVRKSAGQTMFSTIAAHGTLLQPPTWNIVVWKVLFHLLDCVRKSSTTADKEKIESG 1085

  Fly  1063 SGNILIHHSRNTAQKQWAETQVLTLSGVCRVFNTKRELLQMLGDFERAWSLILEFIQNAALSKNG 1127
            .|||||||||:||:||||||.||||:||.|:|||:|.|||.||||.:||.::|:.||:||||||.
Zfish  1086 GGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQQLGDFFKAWEVLLDHIQSAALSKNN 1150

  Fly  1128 EVSLAALKSLQEIMY-------------------------------------------HNTAERT 1149
            |||||||||.|||:.                                           ...|:|.
Zfish  1151 EVSLAALKSFQEILQLVTPIKDTDKPDALSAIDVPSVLMESLQGSGPGRPLVRSDSLAERLAQRY 1215

  Fly  1150 ERALKDPQTAQEQDEE-IWTIAWNIWLSIGMESTKMSTSTSAKLQQQNSNGAETQEDFYIPSQAF 1213
            ......|...:|.|:. :|..|||.|..:|.|.|:..:..:.||             .::|||.|
Zfish  1216 AAQPSLPPPGEELDDSALWWSAWNTWYRVGTECTRPPSGGTDKL-------------VFVPSQPF 1267

  Fly  1214 LTALIQIFPAIFQHIQVKFTAADFDKFCTVLTNAVCIPVQTDAVPYIMSTVSDTLLTPLHDGILD 1278
            ||||||||||::|||...|:..|..|...:|..||.:|:.:|:.|:|:.:.::.:||.|.:.:|.
Zfish  1268 LTALIQIFPALYQHIAGGFSMEDLKKLGVILHGAVSVPISSDSSPFILPSYTEAVLTSLQEAVLT 1332

  Fly  1279 CMELIQKEATKPDSHISQLIPAIFRQLLIFSKFACAPPTFQQSVEHKYAK-SSGHYANN------ 1336
            .::::||.......::..:.||||.|||:|.:|:|.||        :|.| .:.|.||.
Zfish  1333 ALDVLQKAICVSSENLQVMYPAIFEQLLLFVEFSCKPP--------QYGKMETKHVANAKYNQIQ 1389

  Fly  1337 --ASVEVVSMNYIPFGEKSISICVKLYQTTATEDSVVQEQILHDIVKALRTPLAMKYKCLSSSTW 1399
              |..|.|::||:||.|:|:.:.|.||..||...:|:.|::|.:|:|.:|.||.:||.|.:.|||
Zfish  1390 LFAPAEWVALNYVPFAERSLEVVVDLYHKTACHKAVINEKVLQNIIKTVRIPLGLKYACPAESTW 1454

  Fly  1400 KLAISSLISVLHTGLKVAR--AKPQHFASLWDDLADTLDKFLFPASVCTIEDRGLEEIVLDETID 1462
            |||:|||:.||..||.|||  |....|.::|.:||:..:.|||..|. ..::..::|...:|.:|
Zfish  1455 KLAVSSLLKVLSIGLPVARQQASSGKFDTMWPELANAFEDFLFTKST-PPDNLSIQEFQRNEAVD 1518

  Fly  1463 CQVIELLRDEVLPHSHEMPHQFIMQIVVLLNKGSIHSASDTNICYESDWKLREIFAKTCFETLLQ 1527
            .:|::|:..|:||.::.:|.:|:.:|:.:||||||||.|.:....|.|.::||.|:|.|||||||
Zfish  1519 VEVVQLISSEILPFANFIPKEFVGRIMSMLNKGSIHSQSSSFTEAEMDMRMREDFSKVCFETLLQ 1583

  Fly  1528 FSLLEDHANTNNNRLNANVLTAGAAGAGGKDFAGRLAVTALLHRFQEVLKRFNDDERQSGKCPLP 1592
            ||.             :|.::....|     |..|:|::.||.|.|:||:|:.:|||.||:||||
Zfish  1584 FSF-------------SNKVSTPQEG-----FISRMALSVLLQRAQDVLRRYVEDERLSGRCPLP 1630

  Fly  1593 RFRLSEISFVLKAIATLVVSMKKAPASKVNKPAWDQLIGLYPYLVDCTTTTSPEVSRSLREALLQ 1657
            |.:::||.||||||:||:.|:||.....|:...|.|:|.|||.||:|.|.||||||.:|::||..
Zfish  1631 RQQVTEIIFVLKAISTLMDSLKKTQPENVDGNVWAQVIALYPTLVECITCTSPEVSSALKDALGP 1695

  Fly  1658 YTDLLQAPRS 1667
            :.|.:|.|.|
Zfish  1696 FKDFMQPPVS 1705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mon2	NP_001033884.2	DCB	13..184	CDD:292830	83/177 (47%)
		Sec7_N	213..380	CDD:289549	104/169 (62%)
		DUF1981	827..909	CDD:286414	48/81 (59%)
		Mon2_C	912..1665	CDD:292823	353/821 (43%)
mon2	XP_021326251.1	DCB	12..186	CDD:318453	84/180 (47%)
		Sec7_N	218..384	CDD:315455	104/165 (63%)
		DUF1981	<864..919	CDD:312726	33/54 (61%)
		Mon2_C	925..1703	CDD:318446	347/811 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590620
Domainoid	1	1.000	633	1.000	Domainoid score	I165
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44309
Inparanoid	1	1.050	1471	1.000	Inparanoid score	I108
OMA	1	1.010	-	-		QHG55736
OrthoDB	1	1.010	-	-		D411011at2759
OrthoFinder	1	1.000	-	-		FOG0004981
OrthoInspector	1	1.000	-	-		oto41536
orthoMCL	1	0.900	-	-		OOG6_102916
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910