Protein Alignment mon2 and mon2

DIOPT Version :10

• Sequence 1: NP_001033884.2
• Gene: mon2 / 326157
• FlyBaseID: FBgn0031985
• Length: 1684
• Species: Drosophila melanogaster
• Sequence 2: XP_021326252.1
• Gene: mon2 / 100334806
• ZFINID: ZDB-GENE-030131-2712
• Length: 1711
• Species: Danio rerio
• Alignment Length: 1764
• Identity: 831/1764 - (47%)
• Similarity: 1130/1764 - (64%)
• Gaps: 182/1764 - (10%)

  Fly    14 VHKFVEALQADFKTLSLETKKKYPQIKEACEEAISKLCTAGSS--------QQNSVYYTVNQILY 70
            |.|.:|.:|||.::||:|.|||:|.:|||.|..|.|:.|..:.        ::||     ::::.
Zfish    13 VKKLLENMQADLRSLSMECKKKFPPVKEAAESGIVKIKTIAARNTDILAALKENS-----SEVVQ 72

  Fly    71 PLVQGCETKDLKIIKFCLGMMQRLITQQVVDQKGALYITNALWTLMENNIEEVKVLQTVTLLLTT 135
            |.:.||.||:.||.:.||..:|||::.:||.:..|..|.|.||.||||.:||:|:||||.:||||
Zfish    73 PFLMGCGTKEPKITQLCLAAIQRLMSHEVVSEAAAGNIINMLWQLMENGLEELKLLQTVLVLLTT 137

  Fly   136 NTVVHGDTLAKALVLCFRLHYAKNPTIVNTAGATIRQLVSLVFERVYLEKDSVSSLQQQQSSGSP 200
            ||:||.:.|:||:|||||||:.|:....|||.||:||:|::||||:..|.:....|.::    .|
Zfish   138 NTIVHDEVLSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERFKGLNEE----PP 198

  Fly   201 A-EGEGGNQDVQTF---ASDAFLLFQDLVQLVNADQPYWLLGMTEMTRTFGLELLEAVLTNFSAV 261
            | :|....:.|.|.   |.||::|||||.||||||.||||:|||||||||||||||:||.:|..|
Zfish   199 AVQGNCNRRSVSTLRPSAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQV 263

  Fly   262 FHESNDFRLLLKERVCALVIKLFSPNVKHRQLPAPSNGNAPVPAEKPYFPISMRLLRLVAILIQK 326
            |.:..:|..|||||||.|||||||||:|.|| .:.|:..:|.|.|||||||.|||||:|::||:.
Zfish   264 FLQHQEFSFLLKERVCPLVIKLFSPNIKFRQ-GSSSSSASPAPVEKPYFPICMRLLRVVSVLIKH 327

  Fly   327 YHTILVTECEIFLSLIIKFLDPDKPAWQRALALEVIHKLVTRSSLIAFFCKSYDLKNHATNIVHD 391
            ::::|||||||||||::||||.:||.|.||:|:|.:|:|..:..|:..||:|||:|.|:|.:..|
Zfish   328 FYSLLVTECEIFLSLLVKFLDGEKPQWLRAVAVESVHRLCVQPHLLRSFCQSYDMKPHSTKVFRD 392

  Fly   392 MIAAMGSYIRYSLINASA-------------MLNGQQNGVAN-SLTAMSG--SNQCGFMFRGAYL 440
            ::.|:||:|:...|..||             :.:.|.:|... .||...|  :.|..|.:||.::
Zfish   393 IVNALGSFIQSLFILPSAGNTSSTSTPAGGSVSSSQASGPGGPGLTGAGGALTTQAAFEYRGTWI 457

  Fly   441 PLVATYAPGVSKAVYLEMLDKIDASNIPDSYGISVGHAILLDMTRSIGGVIQRTPELHPSHNTAV 505
            ||:.....|.:||.|||||||::..:||:.|.:||..:.|||:.|.|..:|.|  ||........
Zfish   458 PLMNVSVQGSAKATYLEMLDKVEPPSIPEGYAMSVAFSALLDLVRGITNMIDR--ELLRQEQQEA 520

  Fly   506 ITEEE-------HKPLCL----QLVNSSWSALLSAFIPLVETSIDEATTENILKAMQNYAALCGM 559
            :.|||       .:||..    ::||:.|..||:|...|::.|.||..|||||||..:.|:|||.
Zfish   521 MREEEEPVSPPAQEPLAAEVWQEMVNACWCGLLAALSLLLDASTDETATENILKAELSMASLCGR 585

  Fly   560 LEQLQPRDAFIMAMCRASFPPHYAMSIFANTTQSDGDLRCHTRSGSQDLSSQFINSCSGDAGDFR 624
            |..:.||||||.|:|:||.|||||::|.:::..|..: :.::..|.   |.|.::..|    :..
Zfish   586 LGLVTPRDAFITAVCKASLPPHYALTILSSSASSLTN-KVYSIQGQ---SVQMVSPSS----ESH 642

  Fly   625 PQIVAVGTPLPSASLPHSVMQAPVMLTNKNLQCMRAILFLAHNNGGILGTSWHIVLQTLQHLVWI 689
            .|:||||.||.:..      |..|:||.||:||||.:|.|||.:|..|||||.:||.||||||||
Zfish   643 QQVVAVGQPLSAQP------QGTVVLTAKNIQCMRTLLNLAHCHGAHLGTSWQLVLATLQHLVWI 701

  Fly   690 LGLKPSTGGSLQAMPKPAVEA-NVGIQTAVMADLPVLSQMLSQLFESSQYLDDVALHHLIDALCK 753
            |||||:.||.|:  |..|||. :..:.||||.||||:|.:||:|||||||||||:|||||:|||.
Zfish   702 LGLKPAPGGVLK--PGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCS 764

  Fly   754 LSHEAMELAY-ANREPSLFAVAKLLETGLVNMPRIKVLWRPLTNHLLEVCQHRHIRMREWGVEAI 817
            ||.||||:|| .|:||||||||||||||||||.||::||||||.||||||||.:.||||||.|||
Zfish   765 LSMEAMEMAYGTNKEPSLFAVAKLLETGLVNMDRIEILWRPLTAHLLEVCQHPNARMREWGAEAI 829

  Fly   818 TYLVKSALQFKHKTPLKENMELQTMLLSPLSELSTVLHADVRQRQLDCVLQILNTAGEILSFGWP 882
            |.|:|:.|.:||..||.:|..||.:||:||.|||.|||||:||:||:||||||...|:.|..|||
Zfish   830 TSLIKAGLSYKHDPPLSQNQRLQLLLLNPLKELSNVLHADIRQKQLECVLQILQNQGDSLGPGWP 894

  Fly   883 AIIEIIGAVNEHHGEPLIRTAFQCLQLVITDFLTVMPWRCLPLCISTAAKFGSQTQELNISLTAI 947
            .::.:|||:....||.||||||||||||:||||..||..||.:.:..|..||.|.||||||||:|
Zfish   895 LVLGVIGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCMCLQIVVDVAGSFGLQNQELNISLTSI 959

  Fly   948 GLMWNISDFFNQNQDKLMSTQLQDVSIL-------------PDFPGTVKMPQFDKLWMCLYAKLG 999
            ||:|||||:|.|..:.:.....::.::|             |..|.    |.||.||:|||||||
Zfish   960 GLLWNISDYFFQRGEAITEELDKEEAVLLKQAQDKGEPLNRPFHPA----PPFDCLWLCLYAKLG 1020

  Fly  1000 ELCVDLRPAVRKSAGQTLFSTISAHGSLLNPPTWQALVWQVLFPLLDNVRALSSSASNEKVDA-S 1063
            |||||.|||||||||||:||||:|||:||.||||..:||:|||.|||.||..|::|..||::: .
Zfish  1021 ELCVDPRPAVRKSAGQTMFSTIAAHGTLLQPPTWNIVVWKVLFHLLDCVRKSSTTADKEKIESGG 1085

  Fly  1064 GNILIHHSRNTAQKQWAETQVLTLSGVCRVFNTKRELLQMLGDFERAWSLILEFIQNAALSKNGE 1128
            |||||||||:||:||||||.||||:||.|:|||:|.|||.||||.:||.::|:.||:||||||.|
Zfish  1086 GNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQQLGDFFKAWEVLLDHIQSAALSKNNE 1150

  Fly  1129 VSLAALKSLQEIMY-------------------------------------------HNTAERTE 1150
            ||||||||.|||:.                                           ...|:|..
Zfish  1151 VSLAALKSFQEILQLVTPIKDTDKPDALSAIDVPSVLMESLQGSGPGRPLVRSDSLAERLAQRYA 1215

  Fly  1151 RALKDPQTAQEQDEE-IWTIAWNIWLSIGMESTKMSTSTSAKLQQQNSNGAETQEDFYIPSQAFL 1214
            .....|...:|.|:. :|..|||.|..:|.|.|:..:..:.||             .::|||.||
Zfish  1216 AQPSLPPPGEELDDSALWWSAWNTWYRVGTECTRPPSGGTDKL-------------VFVPSQPFL 1267

  Fly  1215 TALIQIFPAIFQHIQVKFTAADFDKFCTVLTNAVCIPVQTDAVPYIMSTVSDTLLTPLHDGILDC 1279
            |||||||||::|||...|:..|..|...:|..||.:|:.:|:.|:|:.:.::.:||.|.:.:|..
Zfish  1268 TALIQIFPALYQHIAGGFSMEDLKKLGVILHGAVSVPISSDSSPFILPSYTEAVLTSLQEAVLTA 1332

  Fly  1280 MELIQKEATKPDSHISQLIPAIFRQLLIFSKFACAPPTFQQSVEHKYAK-SSGHYANN------- 1336
            ::::||.......::..:.||||.|||:|.:|:|.||        :|.| .:.|.||.
Zfish  1333 LDVLQKAICVSSENLQVMYPAIFEQLLLFVEFSCKPP--------QYGKMETKHVANAKYNQIQL 1389

  Fly  1337 -ASVEVVSMNYIPFGEKSISICVKLYQTTATEDSVVQEQILHDIVKALRTPLAMKYKCLSSSTWK 1400
             |..|.|::||:||.|:|:.:.|.||..||...:|:.|::|.:|:|.:|.||.:||.|.:.||||
Zfish  1390 FAPAEWVALNYVPFAERSLEVVVDLYHKTACHKAVINEKVLQNIIKTVRIPLGLKYACPAESTWK 1454

  Fly  1401 LAISSLISVLHTGLKVAR--AKPQHFASLWDDLADTLDKFLFPASVCTIEDRGLEEIVLDETIDC 1463
            ||:|||:.||..||.|||  |....|.::|.:||:..:.|||..|. ..::..::|...:|.:|.
Zfish  1455 LAVSSLLKVLSIGLPVARQQASSGKFDTMWPELANAFEDFLFTKST-PPDNLSIQEFQRNEAVDV 1518

  Fly  1464 QVIELLRDEVLPHSHEMPHQFIMQIVVLLNKGSIHSASDTNICYESDWKLREIFAKTCFETLLQF 1528
            :|::|:..|:||.::.:|.:|:.:|:.:||||||||.|.:....|.|.::||.|:|.||||||||
Zfish  1519 EVVQLISSEILPFANFIPKEFVGRIMSMLNKGSIHSQSSSFTEAEMDMRMREDFSKVCFETLLQF 1583

  Fly  1529 SLLEDHANTNNNRLNANVLTAGAAGAGGKDFAGRLAVTALLHRFQEVLKRFNDDERQSGKCPLPR 1593
            |.             :|.::....|     |..|:|::.||.|.|:||:|:.:|||.||:|||||
Zfish  1584 SF-------------SNKVSTPQEG-----FISRMALSVLLQRAQDVLRRYVEDERLSGRCPLPR 1630

  Fly  1594 FRLSEISFVLKAIATLVVSMKKAPASKVNKPAWDQLIGLYPYLVDCTTTTSPEVSRSLREALLQY 1658
            .:::||.||||||:||:.|:||.....|:...|.|:|.|||.||:|.|.||||||.:|::||..:
Zfish  1631 QQVTEIIFVLKAISTLMDSLKKTQPENVDGNVWAQVIALYPTLVECITCTSPEVSSALKDALGPF 1695

  Fly  1659 TDLLQAPRS 1667
            .|.:|.|.|
Zfish  1696 KDFMQPPVS 1704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mon2	NP_001033884.2	DCB	13..181	CDD:465072	82/174 (47%)
		Sec7_N	213..380	CDD:463703	104/169 (62%)
		DUF1981	827..909	CDD:462756	48/81 (59%)
		Mon2_C	912..1665	CDD:465066	353/821 (43%)
mon2	XP_021326252.1	DCB	12..183	CDD:465072	83/177 (47%)
		Sec7_N	215..385	CDD:463703	107/169 (63%)
		DUF1981	<863..921	CDD:462756	34/57 (60%)
		Mon2_C	924..1702	CDD:465066	347/812 (43%)