DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AspRS-m and DPS1

DIOPT Version :9

Sequence 1:	NP_001260520.2	Gene:	AspRS-m / 326155	FlyBaseID:	FBgn0051739	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_013083.1	Gene:	DPS1 / 850643	SGDID:	S000003941	Length:	557	Species:	Saccharomyces cerevisiae

Alignment Length:	718	Identity:	160/718 - (22%)
Similarity:	249/718 - (34%)	Gaps:	248/718 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 VEVSVTSVKVLNPDDPYDGPIKAKEKKQKFSIDDLEAEEAAAEASANLTSNNGESTEDSAEASTT 440
            ||.|....:|:..:|......||.:|.||......:.||.|.:..|     ..|:.|..|.|..|
Yeast    11 VEESAEPAQVILGEDGKPLSKKALKKLQKEQEKQRKKEERALQLEA-----EREAREKKAAAEDT 70

  Fly   441 A-------------NASLIAEQRAKVADTNK---------FADRTHNCGELTSNDINEKVVICGW 483
            |             ::....::|.|..|.::         |..|.||..:..:.
Yeast    71 AKDNYGKLPLIQSRDSDRTGQKRVKFVDLDEAKDSDKEVLFRARVHNTRQQGAT----------- 124

  Fly   484 LEFQRMNKFFILRDAYGQTQVLLSPKTYG-----LEEYAETGVPIESIVRVEGTV----IPRPAA 539
                  ..|..||......|.|:.....|     :.::|.: :.:||||.|.|.|    .|..:|
Yeast   125 ------LAFLTLRQQASLIQGLVKANKEGTISKNMVKWAGS-LNLESIVLVRGIVKKVDEPIKSA 182

  Fly   540 TINPKMQTGHVEVEADKVVVLNPAKKNLPFEIRKFNRAGER------------LRLTHRYLDLRF 592
            |:.      ::|:...|:..::...:.||..:...:|:...            .||.:|.:|||.
Yeast   183 TVQ------NLEIHITKIYTISETPEALPILLEDASRSEAEAEAAGLPVVNLDTRLDYRVIDLRT 241

  Fly   593 NDMQHNLRLRSAVIMKMREYLINYLGFVEVETPTLF-RRTPGGAQEFVVPTRKAGHFYSLVQSPQ 656
            ...|...|:::.|....||||.. ..|.||.||.|. ..:.||:..|.| |...|..| |.||||
Yeast   242 VTNQAIFRIQAGVCELFREYLAT-KKFTEVHTPKLLGAPSEGGSSVFEV-TYFKGKAY-LAQSPQ 303

  Fly   657 QFKQMLMSGGIDRYFQVARCYRDEATRPDR-QPEFTQLDIELSFTSR-DDIMQLIEETLRYSW-- 717
            ..||.|:....:|.:::...:|.|.:...| ..|||.||:|::|... .:::..:.|...:.:
Yeast   304 FNKQQLIVADFERVYEIGPVFRAENSNTHRHMTEFTGLDMEMAFEEHYHEVLDTLSELFVFIFSE 368

  Fly   718 -PKDFP------RLQTPFR-----------RITYEEAMEKYGNDKPDTRFGFLLNNVSEIIEKSD 764
             ||.|.      |.|.|..           |:||:|.:|
Yeast   369 LPKRFAHEIELVRKQYPVEEFKLPKDGKMVRLTYKEGIE-------------------------- 407

  Fly   765 EFKEKYDDLGAYAIVVRASEAFWNGAARKHYESLGKEFKGTLFVRKFGPTKDVQEKLGKLLGEDV 829
                          ::||:               |||         .|..:|:..:..|.||:
Yeast   408 --------------MLRAA---------------GKE---------IGDFEDLSTENEKFLGK-- 432

  Fly   830 ATEVADKFDLEENDLLFLGIGSKVETRELLGRIRLDYQDFLVENAKIKKPNDFRFLWVID-FPLF 893
              .|.||:|                                         .||   :::| |||
Yeast   433 --LVRDKYD-----------------------------------------TDF---YILDKFPL- 450

  Fly   894 ERNRETNQLESVHHPFTLPHSDDLENFATSCENLESIRSQAYDLVLNGQEVGGGSIRIHDRDMQH 958
                                  ::..|.|..:......|.:||..:.|:|:..|:.||||    |
Yeast   451 ----------------------EIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIHD----H 489

  Fly   959 FILEQILKI----PHD-HLSHLLSALESGCPPHGGIALGLDRLIAILCRARSIRDVIAFPKSLNG 1018
            .:|::.:|.    |.| .|.........|||||.|..:||:|::......::||....||
Yeast   490 ALLQERMKAHGLSPEDPGLKDYCDGFSYGCPPHAGGGIGLERVVMFYLDLKNIRRASLFP----- 549

  Fly  1019 RDP 1021
            |||
Yeast   550 RDP 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS-m	NP_001260520.2	RPA_2b-aaRSs_OBF_like	148..303	CDD:415809
		EcAspRS_like_N	291..410	CDD:239812	10/33 (30%)
		aspS	462..1045	CDD:234775	136/610 (22%)
DPS1	NP_013083.1	PLN02850	19..557	CDD:215456	157/710 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910