Protein Alignment AspRS-m and DARS2

DIOPT Version :9

• Sequence 1: NP_001260520.2
• Gene: AspRS-m / 326155
• FlyBaseID: FBgn0051739
• Length: 1139
• Species: Drosophila melanogaster
• Sequence 2: NP_060592.2
• Gene: DARS2 / 55157
• HGNCID: 25538
• Length: 645
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 286/620 - (46%)
• Similarity: 387/620 - (62%)
• Gaps: 40/620 - (6%)

  Fly   444 SLIAEQRAKVADTNKFADRTHNCGELTSNDINEKVVICGWLEFQRMNKFFILRDAYGQTQVLLSP 508
            ||:...:.::.:.:.|..||:.||||.|:.:.::|.:|||::::|.|.|.:|||..|..||:: |
Human    32 SLLQSSQRRIPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVII-P 95

  Fly   509 KTYGLEEYAET------GVPIESIVRVEGTVIPRPAATINPKMQTGHVEVEADKVVVLNPAKKNL 567
            :    :|.|.:      ..|:||:|:|.||||.|||...||||.||.:|::.....:||..|| |
Human    96 Q----DESAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKK-L 155

  Fly   568 PFEIRKFNRAGERLRLTHRYLDLRFNDMQHNLRLRSAVIMKMREYLINYLGFVEVETPTLFRRTP 632
            ||||:.|.:..|.|||.:||||||...||:||||||.::|||||||.|..|||::||||||:|||
Human   156 PFEIKNFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTP 220

  Fly   633 GGAQEFVVPTRKAGHFYSLVQSPQQFKQMLMSGGIDRYFQVARCYRDEATRPDRQPEFTQLDIEL 697
            |||:||:||:|:.|.||||.||||||||:||.||:|||||||||||||.:||||||||||:|||:
Human   221 GGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEM 285

  Fly   698 SFTSRDDIMQLIEETLRYSWPKDFPRLQTPFRRITYEEAMEKYGNDKPDTRFGFLLNNVSEIIEK 762
            ||..:..|..|||..|:||||.|...:..||..:|:.|.:..||.||||||||..:.::|::...
Human   286 SFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRN 350

  Fly   763 S------DEFKEKYDDLGAYAIVVRASEAFWNGA---ARKHYESLGKEFKGTLFVRKFGP----- 813
            :      |...:.:..:.|..|.        .||   .||..||: :.|....|.::..|
Human   351 TEIGFLQDALSKPHGTVKAICIP--------EGAKYLKRKDIESI-RNFAADHFNQEILPVFLNA 406

  Fly   814 TKDVQEKLGKLLGEDVATEVADKFDLEENDLLFLGIGSKVETRELLGRIRLDYQDFL-VENAKIK 877
            .::....:...:.|....|:....:.:|.|::.|..|...:...|||::||:..|.| .....::
Human   407 NRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLLETRGVVLR 471

  Fly   878 KPNDFRFLWVIDFPLF-ERNRETNQLESVHHPFTLPHSDDLENFATSCENLESIRSQAYDLVLNG 941
            .|..|.||||:||||| .:.....:|||.|||||.||..|:....|   ..:..|||.|||||||
Human   472 DPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYT---EPKKARSQHYDLVLNG 533

  Fly   942 QEVGGGSIRIHDRDMQHFILEQILKIPHDHLSHLLSALESGCPPHGGIALGLDRLIAILCRARSI 1006
            .|:||||||||:.::|.:||..:||.....|||||.||:.|.||||||||||||||.::..:.||
Human   534 NEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSI 598

  Fly  1007 RDVIAFPKSLNGRDPLSNAPVPISDEEMRLYHLSV 1041
            |||||||||..|.|.:||.|..:..||::.||:.|
Human   599 RDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRV 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AspRS-m	NP_001260520.2	RPA_2b-aaRSs_OBF_like	148..303	CDD:415809
		EcAspRS_like_N	291..410	CDD:239812
		aspS	462..1045	CDD:234775	283/602 (47%)
DARS2	NP_060592.2	aspS	50..636	CDD:234775	283/602 (47%)
		Aspartate. /evidence=ECO:0000250	244..247		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160483
Domainoid	1	1.000	403	1.000	Domainoid score	I725
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7093
Inparanoid	1	1.050	526	1.000	Inparanoid score	I1241
Isobase	1	0.950	-	0	Normalized mean entropy	S1606
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D697974at2759
OrthoFinder	1	1.000	-	-		FOG0003334
OrthoInspector	1	1.000	-	-		oto89258
orthoMCL	1	0.900	-	-		OOG6_101912
Panther	1	1.100	-	-	LDO	PTHR22594
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1433
SonicParanoid	1	1.000	-	-		X2226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.880