DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AspRS-m and AsnRS

DIOPT Version :9

Sequence 1:	NP_001260520.2	Gene:	AspRS-m / 326155	FlyBaseID:	FBgn0051739	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001260561.1	Gene:	AsnRS / 35194	FlyBaseID:	FBgn0086443	Length:	558	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	160/729 - (21%)
Similarity:	268/729 - (36%)	Gaps:	245/729 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 DQSLSDTFLSTPEQTVIQIVGKVLGRPKANVNLKYDTGEVEVSVTSVKVLNPDDPYDGPIKAKEK 401
            |:| .|...|.|.:|::|.:......|...:.:  ||          |..|..:||:...|::.|
  Fly    23 DES-GDGSESKPFKTILQAMRHAGKEPFPTIYV--DT----------KDPNAAEPYEPAAKSQLK 74

  Fly   402 K-QKFSI-------DDLEAEEAAAEASANLTSNNGESTEDSAEASTTANASLIAEQRAKVADTNK 458
            | ||..:       |.|:.|...||       ...::.||:.:...:.:.||...::.::.
  Fly    75 KIQKLFVRESHKNADKLQREAEDAE-------KRQQNLEDARKVKISEDPSLPVARKIRIY---- 128

  Fly   459 FADRTHNCGELTSNDINEKVVICGWL-EFQRMNK---FFILRDAYGQTQVLLSPKTYGLEEYAET 519
                     |.|:|. :.:|.:.||: ..:|..|   |..|||..|..|.:|:.:.  .:.|...
  Fly   129 ---------EGTANR-DSRVKVYGWVHRLRRQGKSLIFITLRDGTGFLQCVLNDQL--CQTYDAL 181

  Fly   520 GVPIESIVRVEGTVIPRPAATINPKMQTGHVEVEAD--KVVVLNP-----AKKNLPFEIRKFNRA 577
            .:..||.|.:.||:...|.....|   .|| |:..|  :::.|.|     |..|        ..|
  Fly   182 TLSTESSVVLFGTLKLVPEGKTAP---GGH-ELNVDYWELIGLAPPGGADAILN--------EEA 234

  Fly   578 GERLRLTHRYLDLRFNDMQHNLRLRSAVIMKMREYLINYLGFVEVETPTLFR-RTPGGAQEFVVP 641
            ...::|.:|::.:|..:....|::||.|....|.: ....|:.||..|||.: :..||:..|.:
  Fly   235 QPDVQLDNRHIMIRGENTSKVLKMRSVVTQAFRGH-YEARGYNEVTPPTLVQTQVEGGSTLFKL- 297

  Fly   642 TRKAGHFYSLVQSPQQFKQMLMSGGIDRYFQVARCYRDEATRPDRQ-PEFTQLDIELSFTSRDDI 705
             :..|....|.||.|.:.:..:. .:...|.:::.||.|.:|..|. .|:|.::.|..|.:.||:
  Fly   298 -KYFGEEAYLTQSSQLYLETCLP-ALGDVFTISQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDL 360

  Fly   706 MQLIEE--------TLRYSW-------PKDFPRLQTPFRRITYEEAMEKYGNDKPDTRFGFLLNN 755
            :..:|:        .|:..|       ..||...|.||||:.||:|: |:..:          ||
  Fly   361 LDRLEDLVCDVVDRVLKSPWGYLVKELNPDFKPPQKPFRRMNYEDAI-KWLKE----------NN 414

  Fly   756 VSEIIEKSDEFKEKYDDLGAYAIVVRASEAFWNGAARKHYESLGKEFKGTLFVRKFGPTKDVQE- 819
            |::            ||                               ||.:  :||  :|:.|
  Fly   415 VTK------------DD-------------------------------GTFY--EFG--EDIPEA 432

  Fly   820 ---KLGKLLGEDVATEVADKFDLEENDLLFLGIGSKVETRELLGRIRLDYQDFLVENAKIKKPND 881
               |:...:.|.:                            :|.|...:.:.|.::..|
  Fly   433 PERKMTDTINEPI----------------------------MLCRFPAEIKSFYMQRCK------ 463

  Fly   882 FRFLWVIDFPLFERNRETNQLESVHHPFTLPHSDDLENFATSCENLESIRSQAYDLVL-NGQEVG 945
                        |..|.|   |||                              |::| |..|:.
  Fly   464 ------------EDQRLT---ESV------------------------------DVLLPNVGEIV 483

  Fly   946 GGSIRIHDRDMQHFILEQILK-------IPHDHLSHLLSALESGCPPHGGIALGLDRLIAILCRA 1003
            |||:||:|.       |::||       .|..:..:....: .|..||||..|||:|.:..|...
  Fly   484 GGSMRIYDS-------EELLKGYKREGIDPQPYYWYTDQRV-YGTMPHGGYGLGLERFLCWLLNR 540

  Fly  1004 RSIRDVIAFPKSLN 1017
            ..||:|..:|:.|:
  Fly   541 YHIREVCLYPRFLD 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS-m	NP_001260520.2	RPA_2b-aaRSs_OBF_like	148..303	CDD:415809
		EcAspRS_like_N	291..410	CDD:239812	20/80 (25%)
		aspS	462..1045	CDD:234775	132/596 (22%)
AsnRS	NP_001260561.1	AsnS	122..558	CDD:223096	132/610 (22%)
		AsnRS_cyto_like_N	137..219	CDD:239818	24/87 (28%)
		AsxRS_core	233..552	CDD:238399	100/467 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473208
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22594
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940