DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AspRS-m and dars1

DIOPT Version :9

Sequence 1:	NP_001260520.2	Gene:	AspRS-m / 326155	FlyBaseID:	FBgn0051739	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_001071079.1	Gene:	dars1 / 324025	ZFINID:	ZDB-GENE-061110-135	Length:	531	Species:	Danio rerio

Alignment Length:	675	Identity:	164/675 - (24%)
Similarity:	248/675 - (36%)	Gaps:	208/675 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 KAKEKKQKFSIDDLEAEEAA--AEASANLTSNNGESTEDSAEASTTANASLIAEQ----RAKVAD 455
            ||.:|:||      |||:||  ||..|.|.|...|:.||...........::..|    ||.|
Zfish    20 KALKKQQK------EAEKAAKKAEKQAKLASEQQETEEDDFAKDRYGICPMVQSQQKLDRALV-- 76

  Fly   456 TNKFADRTHNCGELTSNDINEKVVICGWLEFQRMNK---FFILRDAYGQTQVLLSPKTYGLEEYA 517
                     ...:||.....:::.:...:...|...   |.:||......|.||:......::..
Zfish    77 ---------RVQDLTLEKAEQQIWVRARIHTSRAKGKQCFLVLRHQQFTVQALLAVGDRASKQMV 132

  Fly   518 ETGVPI--ESIVRVEGTVIPRPAATINPKMQT---GHVEVEADKVVVLNPAKKNLPFEIRKFNR- 576
            :....|  |||:.||..|     ..:..|:::   ..||:..:::.|::.::..||.::....|
Zfish   133 KFAANITKESIIDVEAVV-----KKVEQKIESCSQQDVELHVERIFVISQSEARLPLQLEDAVRP 192

  Fly   577 -----------AGERLRLTHRYLDLRFNDMQHNLRLRSAVIMKMREYLINYLGFVEVETPTLF-R 629
                       ..:..||.:|.:|||....|...||:|.|....|:.||| .||||::||.:. .
Zfish   193 EGEGDEEGRATVNQDTRLDNRVIDLRTTTSQAIFRLQSGVCQLFRDTLIN-KGFVEIQTPKIISA 256

  Fly   630 RTPGGAQEFVVPTRKAGHFYSLVQSPQQFKQMLMSGGIDRYFQVARCYRDEATRPDRQ-PEFTQL 693
            .:.|||..|.|...|...:  |.||||.:|||.:....|:.|.|...:|.|.:...|. .||..|
Zfish   257 ASEGGANVFTVSYFKTSAY--LAQSPQLYKQMCICADFDKVFCVGPVFRAEDSNTHRHLTEFVGL 319

  Fly   694 DIELSFT--------SRDDIMQLIEETLRYSWPKDFPRLQTPFRRITYEEAMEKYGNDKPDTRFG 750
            |||::|:        |..|.|..|.:.||       .|.||..:.:..:...|.:...:|..|.
Zfish   320 DIEMAFSYHYHEVIDSITDTMVQIFKGLR-------DRFQTEIQTVNKQYPSEPFKFLEPTLRL- 376

  Fly   751 FLLNNVSEIIEKSDEFKEKYDDLGAYAIVVRASEAFWNGAARKHYESLGKEFKGTLFVRKFGPTK 815
                          |:||                                   |...:|..|
Zfish   377 --------------EYKE-----------------------------------GLAMLRAAG--- 389

  Fly   816 DVQEKLGKLLGEDVATEVADKFDLEENDLLFLGIGSKVETRELLGRIRLDYQDFLVENAKIKKPN 880
                           .|:.|:.||            .....:||||:           .|.|...
Zfish   390 ---------------VEMGDEEDL------------STPNEKLLGRL-----------VKEKYDT 416

  Fly   881 DFRFLWVID-FPLFERNRETNQLESVHHPF-TLPHSDDLENFATSCENLESIRSQAYDLVLNGQE 943
            ||   :|:| :||..|            || |:|..::.:            .|.:||:.:.|:|
Zfish   417 DF---YVLDKYPLAVR------------PFYTMPDPNNPK------------YSNSYDMFMRGEE 454

  Fly   944 VGGGSIRIHD------RDMQHFI-LEQILKIPHDHLSHLLSALESGCPPHGGIALGLDRLIAILC 1001
            :..|:.||||      |.|.|.| ||:|        ...:.:...|.|||.|..:||:|:..:..
Zfish   455 ILSGAQRIHDAQLLTERAMHHNIDLEKI--------KAYIDSFRYGAPPHAGGGIGLERVTMLYL 511

  Fly  1002 RARSIRDVIAFPKSLNGRDPLSNAP 1026
            ...::|....||     |||....|
Zfish   512 GLHNVRQTSMFP-----RDPKRLTP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS-m	NP_001260520.2	RPA_2b-aaRSs_OBF_like	148..303	CDD:415809
		EcAspRS_like_N	291..410	CDD:239812	5/12 (42%)
		aspS	462..1045	CDD:234775	142/604 (24%)
dars1	NP_001071079.1	PLN02850	11..531	CDD:215456	163/673 (24%)
		AspRS_cyto_N	90..188	CDD:239815	20/102 (20%)
		AsxRS_core	204..527	CDD:238399	117/463 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910