DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AspRS-m and slm5

DIOPT Version :9

Sequence 1:	NP_001260520.2	Gene:	AspRS-m / 326155	FlyBaseID:	FBgn0051739	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_595079.1	Gene:	slm5 / 2539632	PomBaseID:	SPBC1198.10c	Length:	441	Species:	Schizosaccharomyces pombe

Alignment Length:	606	Identity:	126/606 - (20%)
Similarity:	199/606 - (32%)	Gaps:	240/606 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 HNCGELTSNDINEKVVICGWLEFQRMNK---FFILRDAYGQ--TQVLLSPK-----TYGLEEYAE 518
            || |||.|        |.||:...|..|   |.::.|...|  .||:.||:     :||
pombe    18 HN-GELIS--------INGWVRSIRKLKNVCFAMVSDGTCQQALQVVTSPEQSKKLSYG------ 67

  Fly   519 TGVPIESIVRVEGTVIPRPAATINPKMQTGHVEVEADKVVVLNPAK-KNLPFEIRKFNRAGERLR 582
                  :.|.:||.:    |.:.|.|:.....|:.|:|:.:..... .|.|  |:|.:...|.||
pombe    68 ------ASVNIEGQL----AVSKNAKLGLQQYELLAEKIKIYGQINDDNYP--IQKKHLTTEMLR 120

  Fly   583 -LTHRYLDLRFNDMQHNLRLRSAVIMKMREYLINYLGFVEVETPTLFRRTPGGAQEFVVPTRK-- 644
             :.|  |.||........||||..:..:|:: .:...|.|...|.:......||.|....|.:
pombe   121 QIPH--LRLRTAKQGEIFRLRSDSLKALRQF-FSSKDFTETNPPIITSSDCEGAGEVFTLTPQET 182

  Fly   645 ----------AGHFYS----LVQSPQQFKQMLMSGGIDRYFQVARCYRDEATRPDRQ-PEFTQLD 694
                      ..||:.    |..|.|...:.| :.|:.|.:.::..:|.|.:...|. .||..|:
pombe   183 HKNKSFERDDQKHFFDRPAFLTVSTQLHLEAL-ALGLSRVYTISPAFRAEQSHTSRHLAEFWMLE 246

  Fly   695 IELSF-TSRDDIMQLIEETLRY--------SWPKD-FPRLQTPFRRITYEEAME----------- 738
            .|::| ||...:..|:|:.::|        ::.:| :.:|..|::.:||.||:|
pombe   247 AEVAFMTSLSQLTSLMEDMIKYTLNSLMEQNYHRDHWDQLLKPWKCMTYSEAIEELSAVKKTWKY 311

  Fly   739 --KYGNDKPDTRFGFLLNNVSEIIEKSDEFKEKYDDLGAYAIVVRASEAFWNGAARKHYESLGKE 801
              |:|||.......:|    .||:.|:..|...|
pombe   312 PPKWGNDLSSEHEKYL----CEILHKTPVFVTDY------------------------------- 341

  Fly   802 FKGTLFVRKFGPTKDVQEKLGKLLGEDVATEVADKFDLEENDLLFLGIGSKVETRELLGRIRLDY 866
                       |.| ::....|..|.|....|         |||...:|
pombe   342 -----------PQK-IKPFYMKSSGPDTVAAV---------DLLVPQVG---------------- 369

  Fly   867 QDFLVENAKIKKPNDFRFLWVIDFPLFERNRETNQLESVHHPFTLPHSDDLENFATSCENLESIR 931

pombe   370 ----------------------------------------------------------------- 369

  Fly   932 SQAYDLVLNGQEVGGGSIRIHDRDMQHFILEQILKIPHDHLSHLLSALESGCPPHGGIALGLDRL 996
                       |:.|||:|     ..|  |::....|.: |...|..::....||||..||::||
pombe   370 -----------ELAGGSLR-----KDH--LDEYKTYPPE-LQWYLDLMKYSNAPHGGFGLGIERL 415

  Fly   997 IAIL-CRARSIRDVIAFPKSL 1016
            ||.| ....::::.|.||:|:
pombe   416 IAFLEGENTNVKETIPFPRSV 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS-m	NP_001260520.2	RPA_2b-aaRSs_OBF_like	148..303	CDD:415809
		EcAspRS_like_N	291..410	CDD:239812
		aspS	462..1045	CDD:234775	126/606 (21%)
slm5	NP_595079.1	asnC	9..439	CDD:235176	126/606 (21%)
		EcAsnRS_like_N	23..101	CDD:239813	24/101 (24%)
		AsxRS_core	113..434	CDD:238399	91/480 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910