DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AspRS-m and SPCC736.06

DIOPT Version :9

Sequence 1:	NP_001260520.2	Gene:	AspRS-m / 326155	FlyBaseID:	FBgn0051739	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_587777.1	Gene:	SPCC736.06 / 2538918	PomBaseID:	SPCC736.06	Length:	611	Species:	Schizosaccharomyces pombe

Alignment Length:	622	Identity:	233/622 - (37%)
Similarity:	342/622 - (54%)	Gaps:	76/622 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 INEKVVICGWL-----EFQRMNKFFILRDAYGQTQVLLSPKTYGLEEYAE--------------- 518
            :..||.|.|||     :..:...|..|||.:|....|||.....|::..|
pombe    14 VGTKVSIQGWLVATSRQVSKSISFHQLRDTHGTILQLLSTDKIILQQKREPLVSSTDFSQQKSTS 78

  Fly   519 -----TGVPIESIVRVEGTVIPRPAATINPKMQTGHVEVEADKVVVLNPAKKNLPFEIRKF---N 575
                 :.:|.||:|:|.|.:..||.....|   ....|:..:.|.:||.||     .::.|   .
pombe    79 VMRTLSSIPPESVVQVTGKLQRRPEHDRRP---GNEFELHVEDVKLLNVAK-----NLQLFPGDE 135

  Fly   576 RAGERLRLTHRYLDLRFNDMQHNLRLRSAVIMKMREYLINYLGFVEVETPTLFRRTPGGAQEFVV 640
            :.|.|::|.:|::.||.......||.||.:..::..: .|...|.|||||.||:.||.||:||||
pombe   136 KPGMRIQLANRHIQLRAPKYNSYLRQRSRLAYQVHSF-FNDREFCEVETPLLFKSTPEGAREFVV 199

  Fly   641 PTR-KAGHFYSLVQSPQQFKQMLMSGGIDRYFQVARCYRDEATRPDRQPEFTQLDIELSFTSR-D 703
            |:| ..|.||:|.|||||:||:||:.||..|:|:|||:|||..|.||||||||:|:|:||..: .
pombe   200 PSRLNPGKFYALPQSPQQYKQILMASGIGNYYQIARCFRDEDLRFDRQPEFTQIDLEMSFVDKPH 264

  Fly   704 DIMQLIEETL--RYSWPKDFPRLQTPFRRITYEEAMEKYGNDKPDTRFGFLLNNVSEIIEKSDEF 766
            :||:::|:.|  ..|:.|.. .|..||:.|||:.|::|||:||||.||...|.|::.::.|.|..
pombe   265 EIMEVVEDLLVRLVSFAKGI-TLAKPFQHITYQHAIDKYGSDKPDIRFELPLKNITSLLPKQDPL 328

  Fly   767 KEK----YDDLGAYAIVVRASEAFWNGAARKHYESLGKEFKGTLFVRKFGPTKDVQEKLGKLLG- 826
            ...    |:||         |.:..|..:||..|::|:....| .:|:....:...:||.:|..
pombe   329 ISTEILVYNDL---------SHSLSNAESRKLCEAVGENVVVT-SIREHSQLQTWVKKLPQLRQL 383

  Fly   827 EDVATEVADKFDLEENDLLFLGIGSK--VETRELLGRIRLDYQDFLVENAKIKKPND--FRFLWV 887
            ..||.|:..|..:..|.::|:....|  |.....||::||...:.||:...:.:.:.  .:|:||
pombe   384 PIVAEELNQKLQIGINSIVFMTNRPKYLVSGTTPLGKLRLLLHELLVKKKALPELDKDLLKFVWV 448

  Fly   888 IDFPLFERNRETNQ-LESVHHPFTLPHSDDLENFATSCENLE----SIRSQAYDLVLNGQEVGGG 947
            :|||||....|.|| :.|.|||||.||.||:       ..||    |:|...||:|:||.|:|||
pombe   449 VDFPLFSPTEEKNQSITSTHHPFTAPHWDDV-------HLLEKKPLSVRGLHYDIVVNGIELGGG 506

  Fly   948 SIRIHDRDMQHFILEQILKIPHDH---LSHLLSALESGCPPHGGIALGLDRLIAILCRARSIRDV 1009
            |||||:.|:|.|:|:.:||:|.:.   ..||:..|.||||||||||||.|||.|:|..|..||:|
pombe   507 SIRIHNPDIQRFVLKDVLKLPENRYATFEHLIRVLSSGCPPHGGIALGFDRLAALLTNAPGIREV 571

  Fly  1010 IAFPKSLNGRDPLSNAPVPISDEEMRLYHLSVVDEEE 1046
            |||||:.:|.|.|..:|..|.:|.::.|::::..:.:
pombe   572 IAFPKTSSGADLLIGSPSAIPEEMLKDYNVAITRQTQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS-m	NP_001260520.2	RPA_2b-aaRSs_OBF_like	148..303	CDD:415809
		EcAspRS_like_N	291..410	CDD:239812
		aspS	462..1045	CDD:234775	233/619 (38%)
SPCC736.06	NP_587777.1	AspS	13..606	CDD:223251	233/618 (38%)
		ScAspRS_mt_like_N	17..124	CDD:239816	28/109 (26%)
		AspRS_core	159..579	CDD:238400	188/438 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	312	1.000	Domainoid score	I243
eggNOG	1	0.900	-	-		E1_COG0173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7093
Inparanoid	1	1.050	347	1.000	Inparanoid score	I488
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003334
OrthoInspector	1	1.000	-	-		oto100889
orthoMCL	1	0.900	-	-		OOG6_101912
Panther	1	1.100	-	-	LDO	PTHR22594
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1433
SonicParanoid	1	1.000	-	-		X2226
TreeFam	1	0.960	-	-
	13	12.850