Protein Alignment AspRS-m and Dars2

DIOPT Version :9

• Sequence 1: NP_001260520.2
• Gene: AspRS-m / 326155
• FlyBaseID: FBgn0051739
• Length: 1139
• Species: Drosophila melanogaster
• Sequence 2: NP_766232.1
• Gene: Dars2 / 226539
• MGIID: 2442510
• Length: 653
• Species: Mus musculus
• Alignment Length: 640
• Identity: 305/640 - (47%)
• Similarity: 410/640 - (64%)
• Gaps: 46/640 - (7%)

  Fly   438 STTANASLIAEQRAKVADTNKFADRTHNCGELTSNDINEKVVICGWLEFQRMNKFFILRDAYGQT 502
            |.:.|.:|.::   ::.:.:.|..||:.||||.|:.:.::|.:|||::::|.|.|.:|||.:|..
Mouse    28 SLSRNLALSSQ---RIPEFSSFVARTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDCHGLV 89

  Fly   503 QVLLSPKTYGLEEYAET------GVPIESIVRVEGTVIPRPAATINPKMQTGHVEVEADKVVVLN 561
            |:|: |:    :|.|.:      ..|:||:|||.||||.||....||||.||.:|::.....:||
Mouse    90 QILI-PQ----DESAASVRRILCEAPVESVVRVSGTVISRPPGQENPKMPTGEIEIKVKTAELLN 149

  Fly   562 PAKKNLPFEIRKFNRAGERLRLTHRYLDLRFNDMQHNLRLRSAVIMKMREYLINYLGFVEVETPT 626
            ..|| |||||:.|.:..|.|||.:||||||...||:||||||.::|||||||.|..|||::||||
Mouse   150 ACKK-LPFEIKDFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPT 213

  Fly   627 LFRRTPGGAQEFVVPTRKAGHFYSLVQSPQQFKQMLMSGGIDRYFQVARCYRDEATRPDRQPEFT 691
            ||:||||||:||:||:|:.|.||||.||||||||:||.||:|||||||||||||.:|||||||||
Mouse   214 LFKRTPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFT 278

  Fly   692 QLDIELSFTSRDDIMQLIEETLRYSWPKDFPRLQTPFRRITYEEAMEKYGNDKPDTRFGFLLNNV 756
            |:|||:||..:..|.:|:|..|:||||.|...|.|||..:|:.||:..||.||||||||..:.:|
Mouse   279 QIDIEMSFVEQTGIQRLVEGLLQYSWPGDKDPLVTPFPSMTFAEALATYGTDKPDTRFGMKIVDV 343

  Fly   757 SEIIEKSDEFKEKYDDLGAYAIVVRASEAFWNGAARKHYESLGKEFKGTLFVRKFGPTKDVQEKL 821
            |::. ::.|.:...|.|......|:|. ...:||.....|.:.       |:|||......||.|
Mouse   344 SDVF-RNTELRFLQDALAKPQGTVKAI-CVHDGAKYLRKEDIE-------FIRKFAVHHFSQEVL 399

  Fly   822 --------------GKLLGEDVATEVADKFDLEENDLLFLGIGSKVETRELLGRIRLDYQDFL-V 871
                          .|.:.|:...|:|...:::|.|::.|..|...:...|||::||:..|.| :
Mouse   400 PIFLNAKKNWSSPFAKFIMEEERLELARSMEIQEEDIVLLTAGEHEKACSLLGKLRLECADLLEM 464

  Fly   872 ENAKIKKPNDFRFLWVIDFPLFERNRET-NQLESVHHPFTLPHSDDLENFATSCENLESIRSQAY 935
            ..|.::.|..|.||||:|||||....|: .:|||.|||||.|:|.|:....|   ..|.:|.|.|
Mouse   465 RGAVLRDPAVFSFLWVVDFPLFLAKEESPTELESAHHPFTAPNSSDIHLLYT---EPEKVRGQHY 526

  Fly   936 DLVLNGQEVGGGSIRIHDRDMQHFILEQILKIPHDHLSHLLSALESGCPPHGGIALGLDRLIAIL 1000
            ||||||.|:||||:||||..:|.:|||.:||.....|||||.||:.|.|||||||||||||:.::
Mouse   527 DLVLNGNEIGGGSVRIHDAQLQRYILETLLKEDVKLLSHLLQALDYGAPPHGGIALGLDRLVCLV 591

  Fly  1001 CRARSIRDVIAFPKSLNGRDPLSNAPVPISDEEMRLYHLSVV---DEEEPSTNNT 1052
            ..|.|||||||||||..|:|.:||||..:|.||::.||:.|:   |.||.|.:.|
Mouse   592 TGAPSIRDVIAFPKSYRGQDLMSNAPDSVSPEELKPYHIHVLWPADSEEESASAT 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AspRS-m	NP_001260520.2	RPA_2b-aaRSs_OBF_like	148..303	CDD:415809
		EcAspRS_like_N	291..410	CDD:239812
		aspS	462..1045	CDD:234775	297/607 (49%)
Dars2	NP_766232.1	aspS	49..636	CDD:234775	296/604 (49%)
		EcAspRS_like_N	49..182	CDD:239812	62/138 (45%)
		AspRS_core	186..606	CDD:238400	217/431 (50%)
		Aspartate. /evidence=ECO:0000250	243..246		2/2 (100%)
		GAD	360..451	CDD:281005	20/98 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850831
Domainoid	1	1.000	421	1.000	Domainoid score	I639
eggNOG	1	0.900	-	-		E1_COG0173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7093
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1127
Isobase	1	0.950	-	0	Normalized mean entropy	S1606
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003334
OrthoInspector	1	1.000	-	-		oto92827
orthoMCL	1	0.900	-	-		OOG6_101912
Panther	1	1.100	-	-	LDO	PTHR22594
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1433
SonicParanoid	1	1.000	-	-		X2226
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.730