DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AspRS-m and dars-1

DIOPT Version :9

Sequence 1:	NP_001260520.2	Gene:	AspRS-m / 326155	FlyBaseID:	FBgn0051739	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_499089.1	Gene:	dars-1 / 176334	WormBaseID:	WBGene00001094	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	166/696 - (23%)
Similarity:	263/696 - (37%)	Gaps:	208/696 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 DTGEVEVSVTSVKVLNPDDPYDGPIKAKEKKQKFSIDDLEAEEAAAEASANLTSNNGESTEDSAE 436
            |..|.|....|.|.||         |...|.:|        :|.|.|...|.........|| |.
Worm     3 DAAEGEQPKLSKKELN---------KLARKAKK--------DEKAGEKGGNQQQAAAMDQED-AS 49

  Fly   437 ASTTANASLIAEQRAKVADTNKFADRTHNCGELTSNDINEKVVICGWLEFQR---MNKFFILRDA 498
            .....:..|:..:..||.:..|..       |:..::..:.|.:.|.:...|   .|.|.:||..
Worm    50 KDFYGSYGLVNSKEKKVLNFLKVK-------EINVSNATKDVWVRGRIHTTRSKGKNCFLVLRQG 107

  Fly   499 YGQTQVLLSPKTYGLEEYAE------TGVPIESIVRVEGTV--IPRPAATINPKMQTGHVEVEAD 555
            ....||.:    :..|:.::      :.:..||||.|..|:  :..|..:...|    .||:.|.
Worm   108 VYTVQVAM----FMNEKISKQMLKFVSSISKESIVDVYATINKVDNPIESCTQK----DVELLAQ 164

  Fly   556 KVVVLNPAKKNLPFEIRKFNR--------AGER----------LRLTHRYLDLRFNDMQHNLRLR 602
            :|.|::.:...||.:|...:|        |.|:          .||.:|.:|||........|::
Worm   165 QVFVVSTSAPKLPLQIEDASRRAPTDEEKASEQENQLAVVNLDTRLDNRVIDLRTPTSHAIFRIQ 229

  Fly   603 SAVIMKMREYLINYLGFVEVETPTLFRR-TPGGAQEFVVPTRKAGHFYSLVQSPQQFKQMLMSGG 666
            :.:..:.|. :::..||||:..|.:... :.|||..|.|...|...:  |.||||.:|||.::|.
Worm   230 AGICNQFRN-ILDVRGFVEIMAPKIISAPSEGGANVFEVSYFKGSAY--LAQSPQLYKQMAIAGD 291

  Fly   667 IDRYFQVARCYRDEATRPDR-QPEFTQLDIELSFTSR-DDIMQLIEETLRYSWPKDFPRLQTPFR 729
            .::.:.:...:|.|.:...| ..||..||:|::|... .::|:.|.|.|    .:.|..||.
Worm   292 FEKVYTIGPVFRAEDSNTHRHMTEFVGLDLEMAFNFHYHEVMETIAEVL----TQMFKGLQQ--- 349

  Fly   730 RITYEEAMEKYGNDKPDTRFGF-----LLNNVSEIIEKSDEFKEKYDDLGAYAIVVRASEAFWNG 789
              .|::.:...||..|...|.|     :|               ||.|    ||.:
Worm   350 --NYQDEIAAVGNQYPAEPFQFCEPPLIL---------------KYPD----AITL--------- 384

  Fly   790 AARKHYESLGKEFKGTLFVRKFGPTKDVQEKLGKLLGEDVATEVADKFDLEENDLLFLGIGSKVE 854
             .|::...:|.|                         :|::|.| :||
Worm   385 -LRENGIEIGDE-------------------------DDLSTPV-EKF----------------- 405

  Fly   855 TRELLGRIRLDYQDFLVENAKIKKPNDFRFLWVID-FPLFERNRETNQLESVHHPFTLPHSDDLE 918
                ||::           .|.|...||   :|:| |||           ||...:|:|.:.| |
Worm   406 ----LGKL-----------VKEKYSTDF---YVLDKFPL-----------SVRPFYTMPDAHD-E 440

  Fly   919 NFATSCENLESIRSQAYDLVLNGQEVGGGSIRIHDRDMQHFILEQILKIPHDHLSHLLSALES-- 981
            .:           |.:||:.:.|:|:..|:.||||.||    |.:..|.....|:.:.|.::|
Worm   441 RY-----------SNSYDMFMRGEEILSGAQRIHDADM----LVERAKHHQVDLAKIQSYIDSFK 490

  Fly   982 -GCPPHGGIALGLDRLIAILCRARSIRDVIAFPKSLNGRDPLSNAP 1026
             |||||.|..:||:|:..:.....:||....||     |||....|
Worm   491 YGCPPHAGGGIGLERVTMLFLGLHNIRLASLFP-----RDPKRLTP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS-m	NP_001260520.2	RPA_2b-aaRSs_OBF_like	148..303	CDD:415809
		EcAspRS_like_N	291..410	CDD:239812	10/37 (27%)
		aspS	462..1045	CDD:234775	145/606 (24%)
dars-1	NP_499089.1	PLN02850	4..531	CDD:215456	164/693 (24%)
		AspRS_cyto_N	84..182	CDD:239815	26/105 (25%)
		AsxRS_core	204..527	CDD:238399	113/456 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910