DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AspRS-m and dars2

DIOPT Version :9

Sequence 1:	NP_001260520.2	Gene:	AspRS-m / 326155	FlyBaseID:	FBgn0051739	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_002931512.3	Gene:	dars2 / 100145033	XenbaseID:	XB-GENE-979933	Length:	648	Species:	Xenopus tropicalis

Alignment Length:	623	Identity:	293/623 - (47%)
Similarity:	391/623 - (62%)	Gaps:	43/623 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 KVADTNKFADRTHNCGELTSNDINEKVVICGWLEFQRMNKFFILRDAYGQTQVLLSPKTYGLEEY 516
            :.||.|.|..|||.||||.|..:.::|.:.|||::||.:.|.:|||.:|.|||:| |:.....:.
Frog    45 RTADLNSFVARTHTCGELCSAHVGQEVALYGWLQYQRHDLFVVLRDFHGLTQVIL-PQDEKCSQL 108

  Fly   517 AE--TGVPIESIVRVEGTVIPRPAATINPKMQTGHVEVEADKVVVLNPAKKNLPFEIRKFNRAGE 579
            .:  :...:||:|.|:||||.||....||:|.||.:||.|.:..:||..|| |||||:...:..|
Frog   109 RKMLSEASLESVVVVKGTVIRRPPGQDNPRMSTGEIEVLAKEAHILNTCKK-LPFEIKDAVKKTE 172

  Fly   580 RLRLTHRYLDLRFNDMQHNLRLRSAVIMKMREYLINYLGFVEVETPTLFRRTPGGAQEFVVPTRK 644
            .||:.:||||:|...:|.||||||.::|||||||.|..|||:|||||||:||||||:|||||||:
Frog   173 ALRMQYRYLDIRSGQLQSNLRLRSKIVMKMREYLCNLHGFVDVETPTLFKRTPGGAKEFVVPTRE 237

  Fly   645 AGHFYSLVQSPQQFKQMLMSGGIDRYFQVARCYRDEATRPDRQPEFTQLDIELSFTSRDDIMQLI 709
            .|.||||.||||||||:|:.||:|||||:|||||||.::|||||||||:|||:||..:..|..|:
Frog   238 PGKFYSLPQSPQQFKQLLIIGGLDRYFQIARCYRDEGSKPDRQPEFTQVDIEMSFVDQAGIQSLV 302

  Fly   710 EETLRYSWPKDFPRLQTPFRRITYEEAMEKYGNDKPDTRFGFLLNNVSEIIEKSDEFKEKYDDLG 774
            |..||:|||::...||.||..::|.:||..||.|||||||...:.:|      :.:|:|.  .||
Frog   303 EGMLRFSWPEEKGPLQAPFPVMSYADAMSSYGVDKPDTRFEMKIQDV------TSQFREV--QLG 359

  Fly   775 ------------AYAIVVRASEAFWNGAARKHYESLGKEFKGTLFVRKFGPT-----KDVQEKLG 822
                        ..||.:.....|   ..||..:|: :|.....:.::..|.     ...:..|.
Frog   360 YVQETLRKPHGCVKAICIPGGAKF---IKRKELDSM-QELVKQQYNQEVVPVILRADSSWKSPLE 420

  Fly   823 KLLGEDVATEVADKFDLEENDLLFLGIGSKVETRELLGRIRLDYQDFLVE-NAKIKKPNDFRFLW 886
            |.|...:...:.:..:.:..|:|....|..:.....||::|||....|.| ...::.|..|.|||
Frog   421 KFLSAKLKESLTEAMEAKSEDILLFAAGEHIRACSALGKLRLDAAAQLEEYGVPLRDPTAFHFLW 485

  Fly   887 VIDFPLFERNRETN--QLESVHHPFTLPHSDDLENFATSCENLESIRSQAYDLVLNGQEVGGGSI 949
            |:||||| ..:|.|  :|||.|||||.||.:|.....|   :...:|||.|||||||.|||||||
Frog   486 VVDFPLF-LPKEDNELELESAHHPFTAPHPEDTALLHT---DPAKVRSQHYDLVLNGSEVGGGSI 546

  Fly   950 RIHDRDMQHFILEQILKIPHDHLSHLLSALESGCPPHGGIALGLDRLIAILCRARSIRDVIAFPK 1014
            |||:.::|.::|:.:||.....|||||.||:||.||||||||||||||||:..|.||||||||||
Frog   547 RIHNSNLQRWVLQDVLKEDVSLLSHLLEALQSGAPPHGGIALGLDRLIAIIVGAPSIRDVIAFPK 611

  Fly  1015 SLNGRDPLSNAPVPISDEEMRLYHLSVVDEEEPSTNNT 1052
            |..|||.:||||..:|.|:::.||:.|:   .|.|.::
Frog   612 SFRGRDLMSNAPDMVSAEDLQQYHIQVI---PPCTESS 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS-m	NP_001260520.2	RPA_2b-aaRSs_OBF_like	148..303	CDD:415809
		EcAspRS_like_N	291..410	CDD:239812
		aspS	462..1045	CDD:234775	287/604 (48%)
dars2	XP_002931512.3	aspS	55..641	CDD:234775	287/606 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I742
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7093
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1246
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D697974at2759
OrthoFinder	1	1.000	-	-		FOG0003334
OrthoInspector	1	1.000	-	-		oto103092
Panther	1	1.100	-	-	LDO	PTHR22594
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070