DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31689 and PEN3

DIOPT Version :9

Sequence 1:	NP_001259954.1	Gene:	CG31689 / 326154	FlyBaseID:	FBgn0031449	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_176196.1	Gene:	PEN3 / 842281	AraportID:	AT1G59870	Length:	1469	Species:	Arabidopsis thaliana

Alignment Length:	656	Identity:	165/656 - (25%)
Similarity:	282/656 - (42%)	Gaps:	132/656 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SPFNIIFEDLYYRVEV-------GKDREKKSVLKGIKGTFKSGELTAIMGPSGAGKSSLMNILTG 77
            :|..:.|:|:.|.|::       |....:..:|||:.|.|:.|.|||:||.|||||::||::|.|
plant   863 TPLAMSFDDVKYFVDMPGEMRDQGVTETRLQLLKGVTGAFRPGVLTALMGVSGAGKTTLMDVLAG 927

  Fly    78 LTKSG-VSGKIEIGKARK-------LCGYIMQDDHFFPYFTVEETMLMAATLKISNQCVSLKEKR 134
            ....| :.|.:.|....|       :.||..|.|...|..||.|:::.:|.|::..: |...||.
plant   928 RKTGGYIEGDVRISGFPKVQETFARISGYCEQTDIHSPQVTVRESLIFSAFLRLPKE-VGKDEKM 991

  Fly   135 TLIDYLLNSLKLTKTRQT-----KCSNLSGGQKKRLSIALELIDNPAVLFLDEPTTGLDSSSSFD 194
            ..:|.::..::|...|.:     ..:.||..|:|||:||:||:.||:::|:||||:|||:.::..
plant   992 MFVDQVMELVELDSLRDSIVGLPGVTGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAI 1056

  Fly   195 TIQLLRGLANEGRTIVCTIHQPSTNIYNLFN-LVYVLSAGRCTYQG-TPQNT----VMFLSSVGL 253
            .::.:|...:.|||:||||||||.:|:..|: |:.:...|:..|.| ..||:    ..|.|..|:
plant  1057 VMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDELMLMKRGGQVIYAGPLGQNSHKVVEYFESFPGV 1121

  Fly   254 -ECPPYHNPADFLLECANGDYGDQTEALAEAAK---DIRWRYDQQLMQGEDADAPSETQVAKFNE 314
             :.|..:|||.::||.:         :||...|   |....|:|..:...:.....|..|.....
plant  1122 SKIPEKYNPATWMLEAS---------SLAAELKLSVDFAELYNQSALHQRNKALVKELSVPPAGA 1177

  Fly   315 SQSPGQVQVQVQKIEIQNMESSKDLTKHTYPPTEY-MRLWLLIGRCHLQFFRDWTLTY------- 371
            |                      ||    |..|:: ...|.....|   .::.| .||
plant  1178 S----------------------DL----YFATQFSQNTWGQFKSC---LWKQW-WTYWRSPDYN 1212

  Fly   372 -LKLGIHVLCSILIGLFF---GDSGSNATKQISNVGMIMIHCVYLWY---TTIMPGILRYPAEIE 429
             ::....:..|:|||..|   |.:.|||......:|.:....:::..   :|:.|.:   ..|..
plant  1213 LVRFIFTLATSLLIGTVFWQIGGNRSNAGDLTMVIGALYAAIIFVGINNCSTVQPMV---AVERT 1274

  Fly   430 IIRKETFNNWYKLRTYYLATIITSTPVHIIFSTVYITIGYLMTDQPVEMDR-----FVKYL---- 485
            :..:|.....|....|.::.:....|..:|.:..|..|.|.|.....:.::     ||.|.
plant  1275 VFYRERAAGMYSAMPYAISQVTCELPYVLIQTVYYSLIVYAMVGFEWKAEKFFWFVFVSYFSFLY 1339

  Fly   486 -----LSAVVVTICADGLGVFLGTVLNPVNGTFVGAVSTSCMLMFSGFLILLNHIPAAMRFMAYI 545
                 :..|.:|.......:|.        ..|.|..:     :||||.|....||....:..:|
plant  1340 WTYYGMMTVSLTPNQQVASIFA--------SAFYGIFN-----LFSGFFIPRPKIPKWWIWYYWI 1391

  Fly   546 SPLRYALENMVISLYGN--QRGQLICPPTEFYCHFKNAVTVLRQFGMED-----GDFGHNILMIL 603
            .|:.:.:..:::|.||:  .|.|::....:.         .::|: :||     .||...:..:|
plant  1392 CPVAWTVYGLIVSQYGDVETRIQVLGGAPDL---------TVKQY-IEDHYGFQSDFMGPVAAVL 1446

  Fly   604 IQIAIF 609
            |...:|
plant  1447 IAFTVF 1452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31689	NP_001259954.1	3a01204	15..622	CDD:273361	165/656 (25%)
		ABCG_EPDR	26..239	CDD:213180	82/233 (35%)
		ABC2_membrane	355..558	CDD:279410	43/230 (19%)
PEN3	NP_176196.1	PLN03140	31..1469	CDD:215599	165/656 (25%)
		ABC_trans_N	89..165	CDD:291196
		ABCG_PDR_domain1	154..426	CDD:213200
		ABC2_membrane	527..733	CDD:279410
		PDR_assoc	740..800	CDD:285559
		ABCG_PDR_domain2	864..1102	CDD:213199	83/238 (35%)
		ABC2_membrane	1197..1404	CDD:279410	43/226 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324553at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920