DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31689 and ABCG5

DIOPT Version :9

Sequence 1:	NP_001259954.1	Gene:	CG31689 / 326154	FlyBaseID:	FBgn0031449	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_178984.1	Gene:	ABCG5 / 815846	AraportID:	AT2G13610	Length:	649	Species:	Arabidopsis thaliana

Alignment Length:	637	Identity:	181/637 - (28%)
Similarity:	295/637 - (46%)	Gaps:	60/637 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RTMPDFATSSPFNIIFEDLYYRVEVGKDREKKSVLKGIKGTFKSGELTAIMGPSGAGKSSLMNIL 75
            |..|......|.....|.|....|.|  .:.|.||||:....|..|:.||:||||||||||:.||
plant    31 RRKPRPEADQPVKTEEESLKLEDETG--NKVKHVLKGVTCRAKPWEILAIVGPSGAGKSSLLEIL 93

  Fly    76 TG----LTKSGVSGKIEIGKA--RKLCGYIMQDDHFFPYFTVEETMLMAATLKISNQCVSLKEK- 133
            ..    .|.|....|..:.:|  :|:.||:.|.|..||..|||||:|.:|.|::......|:.:
plant    94 AARLIPQTGSVYVNKRPVDRANFKKISGYVTQKDTLFPLLTVEETLLFSAKLRLKLPADELRSRV 158

  Fly   134 RTLIDYL-LNSLKLTKTRQTKCSNLSGGQKKRLSIALELIDNPAVLFLDEPTTGLDSSSSFDTIQ 197
            ::|:..| |.::...:........:|||:::|:||.:|:|.:|.||.|||||:||||:|:...|.
plant   159 KSLVHELGLEAVATARVGDDSVRGISGGERRRVSIGVEVIHDPKVLILDEPTSGLDSTSALLIID 223

  Fly   198 LLRGLA-NEGRTIVCTIHQPSTNIYNLFNLVYVLSAGRCTYQGTPQNTVMFLSSVGLECPPYHNP 261
            :|:.:| ..||||:.|||||...|...||.|.:|:.|....||:.....::|.|.||..|.:.|.
plant   224 MLKHMAETRGRTIILTIHQPGFRIVKQFNSVLLLANGSTLKQGSVDQLGVYLRSNGLHPPLHENI 288

  Fly   262 ADFLLECANGDYGDQTEALAEAAKDIRWRYDQQLMQGE-DADAPSETQVAKFNESQSPGQVQVQV 325
            .:|.:|.....  .:.:.|.|:.:.......|..:|.: ..|:..|::..||...|...|.:|
plant   289 VEFAIESIESI--TKQQRLQESRRAAHVLTPQTTLQEKRSEDSQGESKSGKFTLQQLFQQTRV-- 349

  Fly   326 QKIEIQNMESSKDLTKHTYPPTEYMRLWLLIGRCHLQFFRDWTL----TYLKLGIHVLCSILIGL 386
              .::..|..:.:.|: .:..:......:|..|.....||...|    |...||    ..|::||
plant   350 --ADVGTMNIATEFTR-DFANSRLEETMILTHRFSKNIFRTKELFACRTVQMLG----SGIVLGL 407

  Fly   387 FFGDSGSNATKQISNVGMIMIHCVYLWYTTI--MPGILRYPAEIEIIRKETFNNWYKLRTYYLAT 449
            .|.:...:.......||:......:|..:||  :|..|:   |.||:.|||.:..|::.:|.:|.
plant   408 IFHNLKDDLKGARERVGLFAFILTFLLTSTIEALPIFLQ---EREILMKETSSGSYRVSSYAVAN 469

  Fly   450 IITSTPVHIIFSTVYITIGYLMTDQPVEMDRFVKY-------LLSAVVVTICADGL--GVFLG-T 504
            .:...|..:|.:.::.|..|.:.........|:.:       |.:|..|.:|...|  ...:| :
plant   470 GLVYLPFLLILAILFSTPVYWLVGLNPSFMAFLHFSLLIWLILYTANSVVVCFSALVPNFIVGNS 534

  Fly   505 VLNPVNGTFVGAVSTSCMLMFSGFLILLNHIPAAMRFMAYISPLRYALENMVISLYGNQRGQLIC 569
            |::.|.|:|         .:|||:.|..:.||....||.|||..:|..|..:|:.:......|
plant   535 VISGVMGSF---------FLFSGYFISNHEIPGYWIFMHYISLFKYPFEGFLINEFSKSNKCL-- 588

  Fly   570 PPTEFYCHFKNAVT---VLRQFGMEDGDFGHNILMILIQIAIFKVLSYFTLK 618
                .|...|..||   :|::....:.....|::::|..:.:::.:||..|:
plant   589 ----EYGFGKCLVTEEDLLKEERYGEESRWRNVVIMLCFVLLYRFISYVILR 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31689	NP_001259954.1	3a01204	15..622	CDD:273361	179/633 (28%)
		ABCG_EPDR	26..239	CDD:213180	87/221 (39%)
		ABC2_membrane	355..558	CDD:279410	56/218 (26%)
ABCG5	NP_178984.1	3a01204	37..638	CDD:273361	179/631 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910