Protein Alignment CG31689 and ABCG4

DIOPT Version :9

• Sequence 1: NP_001259954.1
• Gene: CG31689 / 326154
• FlyBaseID: FBgn0031449
• Length: 624
• Species: Drosophila melanogaster
• Sequence 2: NP_001135977.1
• Gene: ABCG4 / 64137
• HGNCID: 13884
• Length: 646
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 227/616 - (36%)
• Similarity: 349/616 - (56%)
• Gaps: 40/616 - (6%)

  Fly    20 SPFNIIFEDLYYRVEVG---KDREKKSVLKGIKGTFKSGELTAIMGPSGAGKSSLMNILTGLTKS 81
            |..:|.|.:|.|.|..|   :.|..|::||.:.|.|...||..||||||||||:.||||.|..:|
Human    57 SAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRES 121

  Fly    82 GVSGKI-------EIGKARKLCGYIMQDDHFFPYFTVEETMLMAATLKISNQCVSLKEKRTLIDY 139
            |:.|:|       |:...||:..||||||...|:.||.|.|:::|.||:|.:   .:.|:.|:..
Human   122 GMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK---QEVKKELVTE 183

  Fly   140 LLNSLKLTKTRQTKCSNLSGGQKKRLSIALELIDNPAVLFLDEPTTGLDSSSSFDTIQLLRGLAN 204
            :|.:|.|.....|:.:.|||||:|||:|||||::||.|:|.||||:||||:|.|..:.|::.||.
Human   184 ILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQ 248

  Fly   205 EGRTIVCTIHQPSTNIYNLFNLVYVLSAGRCTYQGTPQNTVMFLSSVGLECPPYHNPADFLLECA 269
            .||||:|||||||..::.:|:.:|:||.|:|.::|...|.:.:|..:||.||.|||||||::|.|
Human   249 GGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVA 313

  Fly   270 NGDYGDQTEALAEAAKDIRWRYDQQLMQGEDADAPSETQVAKFNESQSP-GQVQVQVQKIEIQNM 333
            :|:|||....|..|.::           |..|.|..::...| ||..:| .....:|..||
Human   314 SGEYGDLNPMLFRAVQN-----------GLCAMAEKKSSPEK-NEVPAPCPPCPPEVDPIE---- 362

  Fly   334 ESSKDLTKHTYPPTEYMRLWLLIGRCHLQFFRDWTLTYLKLGIHVLCSILIGLFFGDSGSNATKQ 398
                   .||:..:...:..:|..|..|...||..||:|:...||:..:||||.:...|.:|:|.
Human   363 -------SHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV 420

  Fly   399 ISNVGMIMIHCVYLWYTTIMPGILRYPAEIEIIRKETFNNWYKLRTYYLATIITSTPVHIIFSTV 463
            .:|.|.:....::|.:..:||.:|.:|.|:.:..:|..|.||.|:.||||..:...|..::...|
Human   421 FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVV 485

  Fly   464 YITIGYLMTDQPVEMDRFVKYLLSAVVVTICADGLGVFLGTVLNPVN-GTFVGAVSTSCMLMFSG 527
            |.:|.|.||.||.|..||:.:...|....:.|..||:.:|...|.:. .||||.|:...:|:|||
Human   486 YCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSG 550

  Fly   528 FLILLNHIPAAMRFMAYISPLRYALENMVISLYGNQRGQLICPPTEFYCHFKNAVTVLRQFGMED 592
            |.:....||..:::.:|:|.:||..|.:::::||.:||.|.|  .|..|.|:...::||...:||
Human   551 FFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTC--LEERCPFREPQSILRALDVED 613

  Fly   593 GDFGHNILMILIQIAIFKVLSYFTLKHKIKT 623
            .....:.|::.|.....::|:|..|::::|:
Human   614 AKLYMDFLVLGIFFLALRLLAYLVLRYRVKS 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31689	NP_001259954.1	3a01204	15..622	CDD:273361	226/613 (37%)
		ABCG_EPDR	26..239	CDD:213180	103/222 (46%)
		ABC2_membrane	355..558	CDD:279410	69/203 (34%)
ABCG4	NP_001135977.1	3a01204	44..646	CDD:273361	227/616 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141403
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850