DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31689 and abcg2c

DIOPT Version :9

Sequence 1:	NP_001259954.1	Gene:	CG31689 / 326154	FlyBaseID:	FBgn0031449	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	XP_005156580.1	Gene:	abcg2c / 569858	ZFINID:	ZDB-GENE-050517-37	Length:	640	Species:	Danio rerio

Alignment Length:	583	Identity:	153/583 - (26%)
Similarity:	286/583 - (49%)	Gaps:	63/583 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TMPDFATSSPFNIIFEDLYYRVEVGKDR--------EKKSVLKGIKGTFKSGELTAIMGPSGAGK 68
            ::|.|.|..| .:.|..:.||:   |:|        .:|.:||.:.|....| :.|||||:|:||
Zfish    24 SVPCFQTPGP-TVTFHQIRYRI---KERLGMFSCQWREKDILKDVSGIMNPG-MNAIMGPTGSGK 83

  Fly    69 SSLMNILTGL-----TKSG---VSGKIEIGKARKLCGYIMQDDHFFPYFTVEETMLMAATLKISN 125
            :||::::.|.     .|||   |...|.....|....|::|:|......||.|.:..:|.|::|.
Zfish    84 TSLLDVIAGRKDPKGLKSGQVLVDNTIVTSDLRLCSAYVVQNDILMGTLTVRENLAFSANLRLSL 148

  Fly   126 QCVSLKEKRTLIDYLLNSLKLTKTRQTKCSNL-----SGGQKKRLSIALELIDNPAVLFLDEPTT 185
            :..|..:|...::.::..|.|.....||...:     |||:|||.||.:|||.:|::||||||||
Zfish   149 KEYSSSDKEMRVNSVIQELGLKDCADTKIGTMFLRGVSGGEKKRCSIGMELITSPSLLFLDEPTT 213

  Fly   186 GLDSSSSFDTIQLLRGLANEGRTIVCTIHQPSTNIYNLFNLVYVLSAGRCTYQGTPQNTVMFLSS 250
            |||::::...::||:.::.:|:|::.:||||..:|:..|:.:.:::.|...|.|.....:::...
Zfish   214 GLDANTANSIMELLQNISKKGKTVIFSIHQPRYSIFRQFDHLTLMNKGEIIYAGAADKAIIYFED 278

  Fly   251 VGLECPPYHNPADFLLECANGDYGDQTEA--LAEAAKDIRWRYDQQLMQGEDADAPSETQVAKFN 313
            :|.:|.|::|||||.|:..||.......:  ::|....     .::::..|:   |......|
Zfish   279 LGYKCEPFNNPADFFLDVTNGTIRPHKSSNNISEKCSS-----SEEMVDNEN---PLAVMYRK-- 333

  Fly   314 ESQSPGQVQVQVQKIEIQ---NMESSKDLTKHTYPPTEYMRLWLLIGRCHLQFFRDWTLTYLKLG 375
               ||...:::.:..||.   :.|.:|. .|..|....|.:|.|:.||......|:...:|.:|.
Zfish   334 ---SPYFTKLKDRLTEISDGLDPEVTKG-DKIGYATPFYYQLLLVSGRTIRNILRNPQTSYAQLF 394

  Fly   376 IHVLCSILIGLFFGDSGSNATKQISN-VG---MIMIHCVYLWYTTIMPGILRYPAEIEIIRKETF 436
            :::...||:||.:........:.:.| .|   .::|:.|:    ..:..:..:.:|.|:...|..
Zfish   395 LNIFFGILVGLIYYQIPHTLPEALQNRTGAFFFLVINMVF----GNLSAVELFVSERELFIHENS 455

  Fly   437 NNWYKLRTYYLATIITS-TPVHIIFSTVYITIGYLMTDQPVEMDRFVKYLLSAVVVTICADGLGV 500
            :.:|:...|:|:.:... .|..|:...::..|.|.|.....|::.|..|.::..:|::.|    |
Zfish   456 SGFYRTSAYFLSKVFADLIPNRILPVFIFSAIPYFMMGLKPEVEAFFLYCVTMSMVSLSA----V 516

  Fly   501 FLGTVLNPVNGTF-----VGAVSTSCMLMFSGFLILLNHIPAAMRFMAYISPLRYALENMVIS 558
            .|..:::...|:|     :.|:....|::|.|||:.||.:.:.:.::.:.|..||....:.|:
Zfish   517 SLAFLVSASVGSFAMANILIALPYVFMMVFGGFLVNLNSMLSGLSWLKWASIFRYGYNALAIN 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31689	NP_001259954.1	3a01204	15..622	CDD:273361	152/580 (26%)
		ABCG_EPDR	26..239	CDD:213180	77/233 (33%)
		ABC2_membrane	355..558	CDD:279410	44/212 (21%)
abcg2c	XP_005156580.1	ABCG_EPDR	34..267	CDD:213180	77/236 (33%)
		3a01204	37..638	CDD:273361	149/569 (26%)
		ABC2_membrane	377..579	CDD:279410	43/209 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574339
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740