DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31689 and Abcg4

DIOPT Version :9

Sequence 1:	NP_001259954.1	Gene:	CG31689 / 326154	FlyBaseID:	FBgn0031449	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001100286.2	Gene:	Abcg4 / 300664	RGDID:	1305840	Length:	646	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	219/615 - (35%)
Similarity:	350/615 - (56%)	Gaps:	38/615 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SPFNIIFEDLYYRVEVG---KDREKKSVLKGIKGTFKSGELTAIMGPSGAGKSSLMNILTGLTKS 81
            |..:|.|.:|.|.|..|   :.|..|::||.:.|.|...||..||||||||||:.||||.|..:|
  Rat    57 SAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRES 121

  Fly    82 GVSGKI-------EIGKARKLCGYIMQDDHFFPYFTVEETMLMAATLKISNQCVSLKEKRTLIDY 139
            |:.|:|       ::...||:..||||||...|:.||.|.|:::|.||:|.:   .:.|:.|:..
  Rat   122 GMKGQILVNGRPRDLRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK---QEVKKELVTE 183

  Fly   140 LLNSLKLTKTRQTKCSNLSGGQKKRLSIALELIDNPAVLFLDEPTTGLDSSSSFDTIQLLRGLAN 204
            :|.:|.|.....|:.:.|||||:|||:|||||::||.|:|.||||:||||:|.|..:.|::.||:
  Rat   184 ILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAH 248

  Fly   205 EGRTIVCTIHQPSTNIYNLFNLVYVLSAGRCTYQGTPQNTVMFLSSVGLECPPYHNPADFLLECA 269
            .|||::|||||||..::.:|:.:|:||.|:|.::|...|.:.:|..:||.||.|||||||::|.|
  Rat   249 GGRTVICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVA 313

  Fly   270 NGDYGDQTEALAEAAKDIRWRYDQQLMQGEDADAPSETQVAKFNESQSPGQVQVQVQKIEIQNME 334
            :|:|||....|..|.:      :......|...:|.:.:|.....:..|          |:..:|
  Rat   314 SGEYGDLNPMLFRAVQ------NGLCTMAEKKSSPEKNEVPAHCPTCPP----------ELDPIE 362

  Fly   335 SSKDLTKHTYPPTEYMRLWLLIGRCHLQFFRDWTLTYLKLGIHVLCSILIGLFFGDSGSNATKQI 399
            |      ||:..:...:..:|..|..|...||..||:|:...|||..:||||.:...|.:|:|..
  Rat   363 S------HTFATSTLTQFCILFRRTFLSILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASKVF 421

  Fly   400 SNVGMIMIHCVYLWYTTIMPGILRYPAEIEIIRKETFNNWYKLRTYYLATIITSTPVHIIFSTVY 464
            :|.|.:....::|.:..:||.:|.:|.|:.:..:|..|.||.|:.||||..:...|..::...||
  Rat   422 NNTGFLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVY 486

  Fly   465 ITIGYLMTDQPVEMDRFVKYLLSAVVVTICADGLGVFLGTVLNPVN-GTFVGAVSTSCMLMFSGF 528
            .:|.|.||.||.|..||:.:...::...:.|..||:.:|.....:. .||||.|:...:|:||||
  Rat   487 CSIVYWMTGQPAETSRFLLFSALSIATALVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGF 551

  Fly   529 LILLNHIPAAMRFMAYISPLRYALENMVISLYGNQRGQLICPPTEFYCHFKNAVTVLRQFGMEDG 593
            .:....||..:::.:|:|.:||..|.:::::||.:||.|.|  .|.:|.|::...:|.:..:|:.
  Rat   552 FVSFKTIPTYLQWSSYLSYVRYGFEGLILTIYGMERGHLTC--LEDHCPFRDPQIILHELDVEEA 614

  Fly   594 DFGHNILMILIQIAIFKVLSYFTLKHKIKT 623
            ....:.|::.|.....::|:|..|::::|:
  Rat   615 KLYMDFLVLGIFFLALRLLAYLVLRYRVKS 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31689	NP_001259954.1	3a01204	15..622	CDD:273361	218/612 (36%)
		ABCG_EPDR	26..239	CDD:213180	101/222 (45%)
		ABC2_membrane	355..558	CDD:279410	68/203 (33%)
Abcg4	NP_001100286.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.810