DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31689 and abt-2

DIOPT Version :9

Sequence 1:	NP_001259954.1	Gene:	CG31689 / 326154	FlyBaseID:	FBgn0031449	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_490949.3	Gene:	abt-2 / 171782	WormBaseID:	WBGene00000020	Length:	2146	Species:	Caenorhabditis elegans

Alignment Length:	658	Identity:	147/658 - (22%)
Similarity:	239/658 - (36%)	Gaps:	199/658 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GELTAIMGPSGAGKSSLMNILTGL-TKSGVSGKI-------EIGKARKLCGYIMQDDHFFPYFTV 111
            |::|.::|.:||||::.|:||.|| ..|..:.||       ::.:.|.:.|...|.:..|.:.||
Worm   955 GQITGLLGHNGAGKTTTMSILCGLYAPSSGTAKIYQRDIRTDLRRVRDVLGICPQHNVLFSHLTV 1019

  Fly   112 EETMLMAATLKISNQCVSLKEKRTLIDYLLNSLKLTKTRQTKCSNLSGGQKKRLSIALELIDNPA 176
            .|.:.:.|.||    .|...|..:.:|.:|.|:.||:......|.||||.|:||.|.:..|....
Worm  1020 SEQLRLFAALK----GVPDSELTSQVDEILASVSLTEKANKLASTLSGGMKRRLCIGIAFIGGSR 1080

  Fly   177 VLFLDEPTTGLDSSSSFDTIQLLRGLANEGRTI-VCTIHQPSTNIYN------------------ 222
            .:.|||||.|:|.::..|..:||: ...||||| :.|.|....::.:
Worm  1081 FVILDEPTAGVDVTARKDIWKLLQ-RNKEGRTILLSTHHMDEADVLSDRIAILSQDFEKPDLLDG 1144

  Fly   223 ---LFNLVYVLSAGRCTYQGTPQNTVMF------------------------------LSSVGLE 254
               :|...|.|...|..|....:.|.:|                              :..:.||
Worm  1145 KRLIFQHFYALLVCRINYTLKSKRTFLFQVIIPLFLLALAELFVLLQVSTARPDLMVSMPPLPLE 1209

  Fly   255 CPPYHNPADFLLE----CANGDYGDQTEAL-------AEAAKDI--------------RWRYDQQ 294
            .....|.:||.:.    ..|....|...|:       ...|||:              |.||.
Worm  1210 TSIMGNHSDFYVNSWDTAENSTANDILHAMFSSPGTGPRCAKDVPNDLLDTMRRELMFRNRYG-- 1272

  Fly   295 LMQGEDADAPSETQVAKFNESQSPGQVQVQVQKIEIQNMESSKDLTKHTYPPTEYMRL----WLL 355
              .|.:..||...:.:..||        .|.|.|: ...:.::|::..||....|...    |
Worm  1273 --FGRNKPAPGVDKDSVDNE--------YQCQNIQ-GEFDYTEDISNATYNAPIYCGCEDFGW-- 1324

  Fly   356 IGRCHLQFFRDW---TLTYLKLGIHVLCSILIGLFFGDSGSNATK--------QISNVGMIMIHC 409
              .|.|:   ||   ...:|:|.       .....|..:|.|.|:        |::|
Worm  1325 --NCTLE---DWKWNETNWLRLN-------TTDRIFDLTGRNLTQFRLITRFAQLAN-------- 1369

  Fly   410 VYLWYTTIMPGIL------------RYPAEIEIIRK---ETFNN-WYKLRTYYLAT--IITSTPV 456
                  |..|..|            :..|:|:..::   ||..: ...:|...|.|  |..:||.
Worm  1370 ------TTAPFFLGGFSLGHVNQRAQSQADIDTSKRGWLETIKDIAQSMRIINLNTTGIEPATPK 1428

  Fly   457 HIIFSTVYITIGYLMTD--QPVEMDRFVKY---------------LLSAVVV-----TICADGLG 499
            .:......||:..::.|  |.:::...||.               :||..::     .|..:.||
Worm  1429 VLDPFAQNITLNQVVNDLLQNLDVRENVKVWFNNKIWPGFPIASNILSNALLRQEDYAIDPEDLG 1493

  Fly   500 VFLGTVLNPVNGTFVGAVS------TSCMLMF--SGFLILLNHIPAAMRFMAYISPLRYALENMV 556
            :.  |:.:|:|.|....:.      |..:.:|  :..|::|:.|||.  |..|:...|.. |.:.
Worm  1494 IL--TMNHPMNKTISQTLDQNALKFTQALAVFRITILLLVLSMIPAG--FTVYLVEDRIC-EALH 1553

  Fly   557 ISLYGNQR 564
            :.|.|..|
Worm  1554 LQLVGGLR 1561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31689	NP_001259954.1	3a01204	15..622	CDD:273361	147/658 (22%)
		ABCG_EPDR	26..239	CDD:213180	64/213 (30%)
		ABC2_membrane	355..558	CDD:279410	51/261 (20%)
abt-2	NP_490949.3	rim_protein	39..2117	CDD:130324	147/658 (22%)
		ABC_subfamily_A	929..1134	CDD:213230	59/183 (32%)
		ABC_subfamily_A	1802..2024	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000