DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tho2 and THO2

DIOPT Version :9

Sequence 1:	NP_608646.3	Gene:	tho2 / 326153	FlyBaseID:	FBgn0031390	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	NP_014260.3	Gene:	THO2 / 855583	SGDID:	S000005083	Length:	1597	Species:	Saccharomyces cerevisiae

Alignment Length:	1681	Identity:	330/1681 - (19%)
Similarity:	603/1681 - (35%)	Gaps:	429/1681 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 LDRVIPESLLKERLEIDTLQEAGIVKNKSFYSKFIKVKTKLYYKQRRFNLFREESEGFAKLITEL 238
            |.::|| ||.:|..:...:....:.|.::...:.:..|:|  |:.:::||..|.|.|:.:|:..|
Yeast   128 LCKLIP-SLHEELFKFSWISSKLLNKEQTTLLRHLLKKSK--YELKKYNLLVENSVGYGQLVALL 189

  Fly   239 NQEF---DENTTPESIMDIIKSLIGCFNLDPNRVLDIIIE-SFETRPDRWNLFIPLLR------- 292
            ...:   |..:...:.:..|..::|.::||..|.||:|:. |.:...:.:..||.|||
Yeast   190 ILAYYDPDNFSKVSAYLKEIYHIMGKYSLDSIRTLDVILNVSSQFITEGYKFFIALLRKSDSWPS 254

  Fly   293 ---------SYMPTGA--IICEVLGYKFCHFK---DSRTPRSLYHVCALLLKHGVIALNDVYVW- 342
                     |.:..|.  |...::.:....:.   |.........:|.:|||:|.:  |...:|
Yeast   255 SHVANNSNYSSLNEGGNMIAANIISFNLSQYNEEVDKENYERYMDMCCILLKNGFV--NFYSIWD 317

  Fly   343 --------LTPNDGSIKADWEEDLADARE----MVRKL---------NLIQTNKKEDEKDPPPPP 386
                    |.....:::.:.||:.....|    |...|         |.:..|...:.||
Yeast   318 NVKPEMEFLQEYIQNLETELEEESTKGVENPLAMAAALSTENETDEDNALVVNDDVNMKD----- 377

  Fly   387 SVKKFNEE---------KYNANQ------KFGLCEALLKVGDWENAYKIIQKLPEQAVVLQEPIA 436
               |.:||         |....|      |..|.|.||..|.......::::.| :.:.:.|.::
Yeast   378 ---KISEETNADIESKGKQKTQQDILLFGKIKLLERLLIHGCVIPVIHVLKQYP-KVLYVSESLS 438

  Fly   437 RAIADLIHLSVENIY--------YKKCFKAPAGRRPSRNRLYEDSKLVAKMQAKE---------- 483
            |.:..:....:..:|        .|....|....|.....|....:|:.|.:..|
Yeast   439 RYLGRVFEYLLNPLYTSMTSSGESKDMATALMITRIDNGILAHKPRLIHKYKTHEPFESLELNSS 503

  Fly   484 ----FGDLRKYTWPMANV-------------LGPAMHYDTVLMYKLIRIMRKLVVDMGVDSLNGP 531
                :.:......|.|:|             :||.:.....|:.|:.||        ||..:.
Yeast   504 YVFYYSEWNSNLTPFASVNDLFENSHIYLSIIGPYLGRIPTLLSKISRI--------GVADIQ-- 558

  Fly   532 PPNSEAEQHYYDIMSSLD---ACILPSLLYLDNNCSMSEEIWAVLKYFPYHFRYSLY----ARWK 589
             .|..:|..:..|...:|   ..|.|:...|.||...:.|::.::|:||:..||.:|    .:..
Yeast   559 -KNHGSESLHVTIDKWIDYVRKFIFPATSLLQNNPIATSEVYELMKFFPFEKRYFIYNEMMTKLS 622

  Fly   590 NDSYQLHPNLIRRCGLAQRDIKALMKRVSKENVKQLGRLVGKYSHCAPGLLFDYILLQIQIYDNL 654
            .|...|..:..:    |:|:.|:::|.:|.:.:.:..|...|.....|.......:.||:.||.:
Yeast   623 QDILPLKVSFNK----AEREAKSILKALSIDTIAKESRRFAKLISTNPLASLVPAVKQIENYDKV 683

  Fly   655 IGPVCDLLKYLTALSFDCLGYCIIESLTLTGRLRFKDDGTSLSLWLQSLASFCGTIYKKY-SIEL 718
            ...|....||....::|.|.:.::..||. .|...:.||.:.::|:|.|:.|...:.|.. ::::
Yeast   684 SELVVYTTKYFNDFAYDVLQFVLLLRLTY-NRPAVQFDGVNQAMWVQRLSIFIAGLAKNCPNMDI 747

  Fly   719 SGLLQYVANQLKSQKSLDLLILREIVHKMAGVESCEEMTNDQLQAMCGGEQLRGEAGYFSQVRNT 783
            |.::.|:...|.:...:.:.||:|::..:.|:....|:...||..:..|..|:..|.:.......
Yeast   748 SNIITYILKTLHNGNIIAVSILKELIITVGGIRDLNEVNMKQLLMLNSGSPLKQYARHLIYDFRD 812

  Fly   784 KKS--SNRLKEALANNDLAVAICLLMAQQKHCVIYRETAAHSHLKLVGNLYDQCQDTLVQFGTFL 846
            ..|  |:||.....:......|.||:    :.:..:....:||.|::....|:....|..|...:
Yeast   813 DNSVISSRLTSFFTDQSAISEIILLL----YTLNLKANTQNSHYKILSTRCDEMNTLLWSFIELI 873

  Fly   847 GSTYSVDEYVERLPSIITMLREYHINTDVAFFLARPMFTHQINQKYDQLRKDDPNAKKLTTTQKL 911
            ........:.|.:...:.:...:|::|...|.:.|....:|:|..
Yeast   874 KHCLKGKAFEENVLPFVELNNRFHLSTPWTFHIWRDYLDNQLNSN-------------------- 918

  Fly   912 QKYLEATQLIMNPIVESVRPLHSSKVWEDISPQFLVTFWSLSMYDLHVPNESYQREVAKLKQLAQ 976
                  ....::.::|...  .|......||.....|||.||:||:|.....|...        :
Yeast   919 ------ENFSIDELIEGAE--FSDVDLTKISKDLFTTFWRLSLYDIHFDKSLYDER--------K 967

  Fly   977 QAAEGKDSNQSKNKKEQERYIALMEKLNDERKKQHEH---VDKISQRLQEQKDSWFLLRSGKSAK 1038
            .|..|:::....|:|:.    .:..::.|.......|   ..|.|:.:.|:.:.|     .|...
Yeast   968 NALSGENTGHMSNRKKH----LIQNQIKDILVTGISHQRAFKKTSEFISEKSNVW-----NKDCG 1023

  Fly  1039 NDTITQFLQLCLFPRCTFTALDALYCAKFVHTIHNLKTSNFSTLL--CYDR------IFCDITYS 1095
            .|.|..|||.|:.||..|:..|||:.:.|:...  .:|.|..::|  |...      :||
Yeast  1024 EDQIKIFLQNCVVPRVLFSPSDALFSSFFIFMA--FRTENLMSILNTCITSNILKTLLFC----- 1081

  Fly  1096 VTSCTEGEATRYGRFLCAMLETVMRWHADQAVFNKECANYPGFVTKFRVSNQFSEANDHVGYENY 1160
               ||..||...|.|...:|:.                     :.|.|::..|   ||....:.|
Yeast  1082 ---CTSSEAGNLGLFFTDVLKK---------------------LEKMRLNGDF---NDQASRKLY 1119

  Fly  1161 RHVCHKWHYKITKAIVFCLDSKDFMQIRNALIILMRILPHYPVLSKLAQIIERKVDK--VREEEK 1223
                 :||..||:.::..|..|::|.|||.:..:..:...:||:....|::...:::  :.||
Yeast  1120 -----EWHSVITEQVIDLLSEKNYMSIRNGIEFMKHVTSVFPVVKAHIQLVYTTLEENLINEE-- 1177

  Fly  1224 TKRPDLYAIASSYIGQLKLKTPHMLKESVF--------------------------------HQI 1256
              |.|:...:|:.||.||.:....|:...|                                .|:
Yeast  1178 --REDIKLPSSALIGHLKARLKDALELDEFCTLTEEEAEQKRIREMELEEIKNYETACQNEQKQV 1240

  Fly  1257 A----------ERPNKESPTSVGAPAAA---------TRSDKLSPTSPSGN----TQGTRAPGGA 1298
            |          :|...:.|.||.:.:|.         :|::.:.||.||.:    ::.||.....
Yeast  1241 ALRKQLELNKSQRLQNDPPKSVASGSAGLNSKDRYTYSRNEPVIPTKPSSSQWSYSKVTRHVDDI 1305

  Fly  1299 APFY--NSEQKSV-IKEPDAKAASTTRESKSQRGEGNNVTLVSTATSTASNNER----------- 1349
            ..:.  |..||:: :.|.|.:..:..:.||      .|:.:.....||....||
Yeast  1306 NHYLATNHLQKAISLVENDDETRNLRKLSK------QNMPIFDFRNSTLEIFERYFRTLIQNPQN 1364

  Fly  1350 -------ESKQRDL------PAPRESQSRSKDDQQEQAN-----NGSNGSRQ--SESRNRDVERD 1394
                   :|.:|.:      |.|..:.|.|:....|...     :|:.|.:.  ..|..|....|
Yeast  1365 PDFAEKIDSLKRYIKNISREPYPDTTSSYSEAAAPEYTKRSSRYSGNAGGKDGYGSSNYRGPSND 1429

  Fly  1395 RHDQQDQRSISSHRSSRDIVRVKERTEAELHQRSRERSQRLEELEAQQRK------REKTSRRGG 1453
            |...::.:.|||:                .|:||        ||..:..|      |.:..|..|
Yeast  1430 RSAPKNIKPISSY----------------AHKRS--------ELPTRPSKSKTYNDRSRALRPTG 1470

  Fly  1454 EERIRHGDGVETVDLVGSTDNRHYEEFEGRMRDLSSVSNESNGSLHHRQRSHETIEFEKVDSKRR 1518
            .:|   |||              :::.:.|:|:                      |::|..|:|.
Yeast  1471 PDR---GDG--------------FDQRDNRLRE----------------------EYKKNSSQRS 1496

  Fly  1519 KLESSTSSSKKVEELVDSVKKARALKTKERNKDKLSDEERDARKDRKLGRKRDRVDESNSNEHKR 1583
            :|.   ...|..:|..|| .||...:.....:|..|:.|...       .||.:.||:..|:.:.
Yeast  1497 QLR---FPEKPFQEGKDS-SKANPYQASSYKRDSPSENEEKP-------NKRFKKDETIRNKFQT 1550

  Fly  1584 R--REGQNGEEELRDRERHREKSPRERSHEKFDR-ERGGASGSRAEERQYISKSAR 1636
            :  |..::.....|..|..|....|:.:.:...: .:||         .|:|:..|
Yeast  1551 QDYRNTRDSGAAHRANENQRYNGNRKSNTQALPQGPKGG---------NYVSRYQR 1597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tho2	NP_608646.3	THOC2_N	133..627	CDD:292752	109/556 (20%)
		Thoc2	629..703	CDD:288568	18/73 (25%)
		Tho2	939..1240	CDD:288156	74/313 (24%)
		PRP38_assoc	1570..1639	CDD:289628	14/70 (20%)
THO2	NP_014260.3	THOC2_N	30..656	CDD:406523	109/556 (20%)
		Thoc2	658..731	CDD:403051	18/73 (25%)
		Tho2	938..1192	CDD:402722	74/313 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346607
Domainoid	1	1.000	56	1.000	Domainoid score	I2718
eggNOG	1	0.900	-	-		E1_KOG1874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I910
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55273
OrthoFinder	1	1.000	-	-		FOG0003449
OrthoInspector	1	1.000	-	-		oto99417
orthoMCL	1	0.900	-	-		OOG6_102850
Panther	1	1.100	-	-	LDO	PTHR21597
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3684
SonicParanoid	1	1.000	-	-		X2346
TreeFam	0	0.000	Not matched by this tool.
	13	12.830