DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tho2 and Zc3h13

DIOPT Version :9

Sequence 1:	NP_608646.3	Gene:	tho2 / 326153	FlyBaseID:	FBgn0031390	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	XP_036014719.1	Gene:	Zc3h13 / 67302	MGIID:	1914552	Length:	1752	Species:	Mus musculus

Alignment Length:	697	Identity:	139/697 - (19%)
Similarity:	255/697 - (36%)	Gaps:	233/697 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1154 HVGYE------NYRHVCHKWHYKITKAIVFCLDSKDFMQI-------RNALIILMRILPHY---- 1201
            |:.::      ||.:| |:...::.:..:    .::.|::       |..:||...:.|..
Mouse   169 HISHDSDNGDINYDYV-HELSLEMKRQKI----QRELMKLEQENMDKREEIIIQKEVSPEVVRSK 228

  Fly  1202 ----PVLSKLAQIIERK----------------------VDKVREEE---------KTKRPDLYA 1231
                |.|.|.::..:||                      :|:.|..:         :|..|....
Mouse   229 LSPSPSLRKSSKSPKRKSSPKASSAGKKERKAAVVASPLLDQQRNSKGNQSKKKGPRTPSPPPPI 293

  Fly  1232 IASSYIGQLKLKTPHMLKESV-------------FHQIAERPNK---------ESPTSVGAPAAA 1274
            :....:|: |.|..:.:|:.:             |.:..|:.:|         .||.|....:::
Mouse   294 LEDIILGK-KYKEKYKVKDRIEEKPRDGKDRGRDFEKQREKRDKPRSSSPGQHHSPLSSRHHSSS 357

  Fly  1275 TRS----DKLSPT-----SPSGNTQGTRAPG---GAAPF----YNSEQ--------KSVIKEPDA 1315
            ::|    .:.||:     :||.:.|.|..|.   .|:|:    .:|.|        :|.::|...
Mouse   358 SQSGSSIQRHSPSPRRKRTPSPSYQRTLTPSLRRSASPYPTHCLSSPQRKQSPPRHRSPMREKGR 422

  Fly  1316 KAASTTRESKSQRGEGNNVTLVSTATSTASNNERESK--QRDLPAPRESQSR--SKDDQQEQANN 1376
            .....|.:|..:|.|....|.........:..||||:  .||...||:|:.|  ::|.::.:.:.
Mouse   423 HDHERTSQSHDRRHERREETRGKRDREKDTREERESEHDHRDDREPRDSRDRRDTRDRRELRDSR 487

  Fly  1377 GSNGSRQSESRNRDVE-----------RDRHDQQDQRSISSH-------------RSSRDIVRVK 1417
            ....||:....:||.:           ||.||.:|:.:..:|             |.:|||..|:
Mouse   488 DMRDSREMRDYSRDAKESRDPRDSRSARDVHDYRDREARDAHARDVRDARDARDARDARDIRDVR 552

  Fly  1418 E-----------------------------------------------------RTEAELHQRS- 1428
            :                                                     :.||..:.|:
Mouse   553 DVRDVRDVRDVRDVRDVRDVRDVRDARDVRDVRDARDVRDVRDVRDGHRKEDVYQEEARSYGRNH 617

  Fly  1429 -RERSQRLE---------ELEAQQRKREKTSRRGGE--ERIRHGDGVETVDLVGSTDNRHYEEFE 1481
             ||.|.|:|         ..|.:..:..::..||.|  |:...|.....:|...|..|.| :.:|
Mouse   618 LREESSRVELRNDSRNESRSEIRNDRMGRSRGRGPELPEKGSRGTRGSQMDSHSSGSNYH-DSWE 681

  Fly  1482 GRM----------RDLSSVSNESNGSLHHRQRSHETIEFEKVDSKRRKLESST-----SSSKKVE 1531
            .|.          ||....:.:|:....|.:|       ::.|::.|....|:     ..|:::|
Mouse   682 TRSSYPERDRYPERDTRDPARDSSFERRHGER-------DRRDNRERDQRPSSPIRHQGRSEELE 739

  Fly  1532 ELVDSVKKARAL-KTKERNKDKLSDEERDARKDRKLGRKRDRVDESNSN---EHKRRREGQNGEE 1592
            .  |..::.|.: :..||..|::.|.:||..::|:..|:|:|..|....   |.:|.||.:...|
Mouse   740 R--DERREERRIDRVDERRDDRVRDRDRDREREREREREREREREKERERELERERARERERERE 802

  Fly  1593 ELRDRERHREKSPRERSHEKFDRERGGASGSRAEERQYISKSARSSR 1639
            :.|:|||.||:..|:|.|:: :|||     .|..||:...:..|..|
Mouse   803 KERERERERERDQRDRDHDR-ERER-----EREREREKEREREREER 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tho2	NP_608646.3	THOC2_N	133..627	CDD:292752
		Thoc2	629..703	CDD:288568
		Tho2	939..1240	CDD:288156	20/137 (15%)
		PRP38_assoc	1570..1639	CDD:289628	24/71 (34%)
Zc3h13	XP_036014719.1	zf-CCCH	42..63	CDD:395517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1874
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900