DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tho2 and thoc2

DIOPT Version :9

Sequence 1:NP_608646.3 Gene:tho2 / 326153 FlyBaseID:FBgn0031390 Length:1642 Species:Drosophila melanogaster
Sequence 2:XP_005157191.1 Gene:thoc2 / 368417 ZFINID:ZDB-GENE-030616-54 Length:1560 Species:Danio rerio


Alignment Length:1638 Identity:676/1638 - (41%)
Similarity:967/1638 - (59%) Gaps:190/1638 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 KHLDKSGRSEFLKYLKHQLQDAADTPVYDKNGVFKQGISNAIYQLLWQTLRFTHKKDIVLHLLLE 130
            |:.|||||:|||::    .||.|..   .......:.:..|.|:|.|..::.:.|.|:...||.:
Zfish    12 KNWDKSGRNEFLQF----FQDLAGK---SSGHELVKDLQTAFYELCWHAIQGSLKVDVAASLLAD 69

  Fly   131 VVALHADFPSLIVDVVNILDSETSLITDGLQEERH---AFVQLVKDLDRVIPESLLKERLEIDTL 192
            |:.|..|.||::.||:.|||.||     |..||:|   .|.|||......||:.:|||||:.:||
Zfish    70 VMELRDDMPSILADVLCILDIET-----GCLEEKHKRDLFTQLVGACLICIPDGVLKERLDPETL 129

  Fly   193 QEAGIVKN-KSFYSKFIKVKTKLYYKQRRFNLFREESEGFAKLITELNQEFDENTTPESIMDIIK 256
            :..|::|. :.|..|.:|:||||:|||::|||.|||:||:|||||||.|:...|.|...:::.||
Zfish   130 ESLGLIKQAQQFNQKIVKIKTKLFYKQQKFNLLREENEGYAKLITELGQDLTGNLTSHIVLENIK 194

  Fly   257 SLIGCFNLDPNRVLDIIIESFETRPDRWNLFIPLLRSYMPTGAIICEVLGYKFCHFKD--SRTPR 319
            |||||||||||||||||:|.:|.|.|:...||||::|||.....:|.:||:||...::  ..||.
Zfish   195 SLIGCFNLDPNRVLDIILEVYECRSDQDEFFIPLIKSYMCEHQTLCHMLGFKFKFHQEPNGETPS 259

  Fly   320 SLYHVCALLLKHGVIALNDVYVWLTPNDGSIKADWEEDLADAREMVRKLNLI-----QTNKKEDE 379
            ||||:.|.||:|.:|||.|:||.|.|.|.||..:.:.|:.:|:::.|||.::     :|..||.|
Zfish   260 SLYHIAAALLQHDLIALEDLYVHLLPLDSSIVEEHKRDILEAKQIARKLTMVVLPSEKTEDKEKE 324

  Fly   380 KDPPPPPSVKKFNEEKYNANQKFGLCEALLKVGDWENAYKIIQKLPEQAVVLQEPIARAIADLIH 444
            ||.      ::...||...|||.||.||||::.||:::..|:.:||.......:.||.|:..|:|
Zfish   325 KDK------EEEKNEKPPDNQKLGLLEALLRISDWQHSQSIMDQLPAFYATSHKAIAVALCQLLH 383

  Fly   445 LSVENIYYKKCFKAPAGRR-----PSRNRLYEDSKLVAKMQAKEFGDLRKYTWPMANVLGPAMHY 504
            |.::.:|.:.  ..|.|.:     |.:|:       .|...|:.|.||.:..:.|...|||.:.:
Zfish   384 LIIDPLYRRA--GVPKGAKGSLITPLQNK-------HAPQPAENFDDLSRDVFTMLCYLGPHLSH 439

  Fly   505 DTVLMYKLIRIMRKLVVDMGVDSLNGPPPNSEAEQHYYDIMSSL--------DACILPSLLYLDN 561
            |.:|..|::|:.:..:.:.          .||:.|...|.|.||        |..:||||..::.
Zfish   440 DPILFAKMVRLGKSFMKEY----------QSESRQDSRDKMDSLLGSFLSIADQVLLPSLSLMEC 494

  Fly   562 NCSMSEEIWAVLKYFPYHFRYSLYARWKNDSYQLHPNLIRRCGLAQRDIKALMKRVSKENVKQLG 626
            |..||||:|...|:|||..||.||.:|||::|..||.|::.........|.:|||::|||||..|
Zfish   495 NACMSEELWGFFKFFPYQHRYRLYGQWKNETYSNHPLLVKIKAQTVDRSKYIMKRLTKENVKPSG 559

  Fly   627 RLVGKYSHCAPGLLFDYILLQIQIYDNLIGPVCDLLKYLTALSFDCLGYCIIESLTLTGRLRFKD 691
            |.:||.||..|.:||||||.|||.|||||.||.|.|||||:|::|.|.|||||:|....:.:.|.
Zfish   560 RQIGKLSHSNPTILFDYILSQIQWYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKEKMKH 624

  Fly   692 DGTSLSLWLQSLASFCGTIYKKYSIELSGLLQYVANQLKSQKSLDLLILREIVHKMAGVESCEEM 756
            |.|::|.|||||||.||.:::||.|||:||||||.||||:.||.|||||:|:|.||||:|..:||
Zfish   625 DDTTISSWLQSLASLCGAVFRKYPIELAGLLQYVTNQLKAGKSFDLLILKEVVQKMAGIEITDEM 689

  Fly   757 TNDQLQAMCGGEQLRGEAGYFSQVRNTKKSSNRLKEALANNDLAVAICLLMAQQKHCVIYRETAA 821
            |.:||:||.|||||:.|.|||.|:|||||||.|||:||.:::||:.:|||||||::.|::.| ..
Zfish   690 TVEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHELALPLCLLMAQQRNGVVFSE-GG 753

  Fly   822 HSHLKLVGNLYDQCQDTLVQFGTFLGSTYSVDEYVERLPSIITMLREYHINTDVAFFLARPMFTH 886
            ..||||||.|||||.|||||||.||.|..|.::|::|:||:..:..:.|...|.||||:|||:.|
Zfish   754 EKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSVDVLCNQLHTPHDAAFFLSRPMYAH 818

  Fly   887 QINQKYDQLRKDDPNAKKLTTTQKLQKYLEATQLIMNPIVESVRPLHSSKVWEDISPQFLVTFWS 951
            ||..|||:|:|.:...::   .||:.||:.|.:.:|.|:.|:|..||..|||:|:.|||..||||
Zfish   819 QILSKYDELKKAEKGNRQ---QQKVHKYITACEQVMAPVHEAVVSLHLPKVWDDLRPQFYATFWS 880

  Fly   952 LSMYDLHVPNESYQREVAKLKQLAQQAAEGKDSNQSKNKKEQERYIALMEKLNDERKKQHEHVDK 1016
            |:||||.||:.:|.|||.|||...:...:..:...:|.|||:||..||.:||.:|.|||.|||.:
Zfish   881 LTMYDLAVPHNAYDREVNKLKMQIKSIDDNTEMPPNKKKKEKERCTALQDKLQEEEKKQLEHVQR 945

  Fly  1017 ISQRLQEQKDSWFLLRSGKSAKNDTITQFLQLCLFPRCTFTALDALYCAKFVHTIHNLKTSNFST 1081
            :..||:.:||:|.|   .||.||:|||:|||||:||||.|:|:||:|||:||..:|..||.||.|
Zfish   946 VLHRLKLEKDNWLL---AKSTKNETITKFLQLCIFPRCVFSAIDAVYCARFVELVHQQKTPNFCT 1007

  Fly  1082 LLCYDRIFCDITYSVTSCTEGEATRYGRFLCAMLETVMRWHADQAVFNKECANYPGFVTKFRVSN 1146
            ||||||:|.||.|:|.||||.|:.|||||||.|||||.|||:|:|::.|||.|||||:|.||.|.
Zfish  1008 LLCYDRVFSDIIYTVASCTENESRRYGRFLCCMLETVTRWHSDRAIYEKECGNYPGFLTIFRASG 1072

  Fly  1147 QFSEAN--DHVGYENYRHVCHKWHYKITKAIVFCLDSKDFMQIRNALIILMRILPHYPVLSKLAQ 1209
             |...|  |.:.|||:|||.||||||:|||.|.||::.::..|||.||:|.:|||.||.:..|.|
Zfish  1073 -FDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQ 1136

  Fly  1210 IIERKVDKVREEEKTKRPDLYAIASSYIGQLKLKTPHMLKESVFHQIAERPNKES--------PT 1266
            .:|.:|.|:.:|||.|||||||:|..|.||||.:..||:.|:.||. .|:|.:.:        |.
Zfish  1137 ALECRVHKICQEEKEKRPDLYALAMGYSGQLKGRKVHMVPENEFHH-KEQPVRSTTTGTLQNGPG 1200

  Fly  1267 SVGAPAAATRSDKLSPTSPSGNTQGTRAPGGAAPFYNSEQKSVIKEPDAKAASTTRESKSQRGEG 1331
            ::|..:..|       .:.:|.|:    .|.......|:.||...:..|...|||         .
Zfish  1201 NIGKTSTTT-------AASAGKTE----DGVVEDSEKSKDKSQAAQKTASKNSTT---------A 1245

  Fly  1332 NNVTLVSTATSTASNNERESKQRDLPAPRESQSRSKDDQQEQANNGSNGSRQSESRNRDVERDRH 1396
            |.|:  |:..|:..|:.:.||:::   .:|..::.|.:::|: |.||....::.::::..|    
Zfish  1246 NKVS--SSNGSSTPNSMKGSKEKE---DKEKTTKEKKEKKEK-NPGSTPEAKTGAKDKQKE---- 1300

  Fly  1397 DQQDQRSISSHRSSRDIVRVKERTEAELHQRSRERSQRLEELEAQQRKREKTSRRGGEERIRHGD 1461
                                 ||::.|....|:|::.:.::.:.:..|:|:.|:           
Zfish  1301 ---------------------ERSKEEKPIDSKEKTPKADKDKRKDDKKEEKSK----------- 1333

  Fly  1462 GVETVDLVGSTDNRHYEEFEGRMRDLSSVS----------NESNGSLHHRQRSHETIEFEKVDSK 1516
                      .|.:..|:...:.||.||.|          |...|||.......|.:|.|: :.|
Zfish  1334 ----------IDGKSIEKDWSKERDASSDSKTKESSKLEKNAGAGSLKSLVPRSEGVESER-EQK 1387

  Fly  1517 RRKLE--SSTSSSKKVEELVDSVK-----------------KARALKTKERNKDKLSDEERDARK 1562
            ||||:  ||.|.|..|::.::..|                 |.:..:.||.:|.:...:||:.::
Zfish  1388 RRKLDTHSSPSHSSAVKDNLNDFKDSTLKHHPNHTTVLSKIKEKDDEKKESDKSRDRSKEREKKE 1452

  Fly  1563 DRKLGRKRDRV--DESNSNEHKRRREGQNGEEELRDRERHREKSPRERSHEKFDRERGGASGSRA 1625
            ||| .||||.:  |...|.|.|||:: :||   :...:..:..||.|..|.. |::....|.|.:
Zfish  1453 DRK-DRKRDYLNSDREMSQEAKRRKD-ENG---MSSSKHSKSASPSESPHSN-DKDNSKRSKSTS 1511

  Fly  1626 EERQYISKSARSS 1638
            :::..::|..::|
Zfish  1512 KDKSDLAKLEKTS 1524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tho2NP_608646.3 THOC2_N 133..627 CDD:292752 207/517 (40%)
Thoc2 629..703 CDD:288568 43/73 (59%)
Tho2 939..1240 CDD:288156 171/302 (57%)
PRP38_assoc 1570..1639 CDD:289628 19/71 (27%)
thoc2XP_005157191.1 THOC2_N 11..560 CDD:292752 228/584 (39%)
Thoc2 562..636 CDD:288568 43/73 (59%)
Tho2 868..1167 CDD:288156 171/302 (57%)
DUF1777 1442..>1557 CDD:285811 26/89 (29%)
NP1-WLL 1442..1528 CDD:256580 26/89 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170596228
Domainoid 1 1.000 369 1.000 Domainoid score I862
eggNOG 1 0.900 - - E1_KOG1874
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H69669
Inparanoid 1 1.050 1149 1.000 Inparanoid score I202
OMA 1 1.010 - - QHG55273
OrthoDB 1 1.010 - - D979205at2759
OrthoFinder 1 1.000 - - FOG0003449
OrthoInspector 1 1.000 - - oto41405
orthoMCL 1 0.900 - - OOG6_102850
Panther 1 1.100 - - LDO PTHR21597
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3684
SonicParanoid 1 1.000 - - X2346
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1716.800

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