DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tho2 and Thoc2l

DIOPT Version :9

Sequence 1:	NP_608646.3	Gene:	tho2 / 326153	FlyBaseID:	FBgn0031390	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	NP_001160053.1	Gene:	Thoc2l / 100042165	MGIID:	3040669	Length:	1589	Species:	Mus musculus

Alignment Length:	1649	Identity:	666/1649 - (40%)
Similarity:	967/1649 - (58%)	Gaps:	182/1649 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EVFKHLDKSGRSEFLKYLKHQLQD-AADTPVYDKNGVFKQGISNAIYQLLWQTLRFTHKKDIVLH 126
            |..|..:||||.|||:..:...:. :.||..:       :....|:|:|.:..::.|.|.:...:
Mouse    13 EWIKTWEKSGRGEFLRLCRILSESKSRDTFAW-------RDFQQALYELSYHVIKGTLKPEQASN 70

  Fly   127 LLLEVVALHADFPSLIVDVVNILDSETSLITDGLQEERHAFVQLVKDLDRVIPESLLKERLEIDT 191
            :|.::.....|.|.::.|:..|||.||:.:.:  :.:|..|.||:.....::.:::|||||:.:|
Mouse    71 VLNDISEFREDIPFILADIFCILDIETNCLEE--KSKRDHFTQLILACLYLVSDTVLKERLDPET 133

  Fly   192 LQEAGIVK-NKSFYSKFIKVKTKLYYKQRRFNLFREESEGFAKLITELNQEFDENTTPESIMDII 255
            |...|::| ::.|..|.:|:||||:|||::|||.|||:||:||||.||.|:...|.|.:.|::|:
Mouse   134 LGSLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIVELGQDLSGNITSDLILEIL 198

  Fly   256 KSLIGCFNLDPNRVLDIIIESFETRPDRWNLFIPLLRSYMP--TGAIICEVLGYKFCHFKD--SR 316
            ||||||||||||||||||:|.||.||:..:.||.||.:||.  ....:|.:||:||..:::  ..
Mouse   199 KSLIGCFNLDPNRVLDIILEVFECRPEHHDFFISLLEAYMSMCEPHTLCHILGFKFKFYQEPNGE 263

  Fly   317 TPRSLYHVCALLLKHGVIALNDVYVWLTPNDGSIKADWEEDLADAREMVRKLNL-IQTNKKEDEK 380
            ||.|||...|:||:..:|.|:|:||.|.|.|..|.::::.::.:|:::|:||.: :..::|.||:
Mouse   264 TPSSLYRAAAVLLQFNLIDLDDLYVHLLPADSCIVSEYKREIVEAKQIVKKLTMVVLPSEKSDER 328

  Fly   381 DPPPPPSVKKFNE--EKYNANQKFGLCEALLKVGDWENAYKIIQKLPEQAVVLQEPIARAIADLI 443
            :     ..||.::  ||...|||.||.||||.:|||::|..|:..:|.......:.||.||.:||
Mouse   329 E-----KEKKKDDKVEKAPDNQKLGLLEALLIIGDWKHAQSIMDHMPPYYATSHKVIALAICNLI 388

  Fly   444 HLSVENIYYKKCFKAPAGRRPSRNRLYEDSKLVAKMQAKEFGDLRKYTWPMANVLGPAMHYDTVL 508
            |:::|.||.:  ...|.|.:.|.....::.|  |..||:.|.|||:..:.|...|||.:.:|.:|
Mouse   389 HITIEPIYRR--VGVPKGAKGSPVNALQNKK--APKQAESFEDLRRDVFSMFYYLGPHLSHDPIL 449

  Fly   509 MYKLIRIMRKLVVDMGVDSLNGPPPNSEAEQHYYD-IMSSLDACILPSLLYLDNNCSMSEEIWAV 572
            ..|::||.:..:.:...|   |...|.|..:.... ::|..|..:||||..:|.|..||||:|.:
Mouse   450 FAKVVRIGKSFMKEFQSD---GKQENKEKMEAILSCLLSVTDQVLLPSLSLMDCNACMSEELWGM 511

  Fly   573 LKYFPYHFRYSLYARWKNDSYQLHPNLIRRCGLAQRDIKALMKRVSKENVKQLGRLVGKYSHCAP 637
            .|.|||..||.||.:|||::|..||.|::.........|.:|||::|||||..||.:||.||..|
Mouse   512 FKTFPYQHRYRLYGQWKNETYNSHPLLVKVKAYTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNP 576

  Fly   638 GLLFDYILLQIQIYDNLIGPVCDLLKYLTALSFDCLGYCIIESLTLTGRLRFKDDGTSLSLWLQS 702
            .:||||||.|||.|||||.||.|.|||||||::|.|.|||||:|....:.|.|.|.|::|.||||
Mouse   577 TILFDYILSQIQKYDNLITPVVDSLKYLTALNYDVLAYCIIEALANPEKERMKHDDTTISNWLQS 641

  Fly   703 LASFCGTIYKKYSIELSGLLQYVANQLKSQKSLDLLILREIVHKMAGVESCEEMTNDQLQAMCGG 767
            ||||||.:::||.|:|:|||||||||||:.||.|||||:|:|.||||:|..||||.:||:||.||
Mouse   642 LASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEVTEEMTMEQLEAMTGG 706

  Fly   768 EQLRGEAGYFSQVRNTKKSSNRLKEALANNDLAVAICLLMAQQKHCVIYRETAAHSHLKLVGNLY 832
            |||:.|.|||.|:|||||||.|||:||.::|||:.:|||||||::.||::| ....||||||.||
Mouse   707 EQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQE-GGEKHLKLVGKLY 770

  Fly   833 DQCQDTLVQFGTFLGSTYSVDEYVERLPSIITMLREYHINTDVAFFLARPMFTHQINQKYDQLRK 897
            |||.|||||||.||.|..|.|:|::|:|||..:..|:|...|.||||:|||:.|.|:.|||:|:|
Mouse   771 DQCHDTLVQFGGFLASNLSTDDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKK 835

  Fly   898 DDPNAKKLTTTQKLQKYLEATQLIMNPIVESVRPLHSSKVWEDISPQFLVTFWSLSMYDLHVPNE 962
            .:..:|:   ..|:.||:.:.:::|.|:.|:|..||.||||:||||||..|||||:||||.||:.
Mouse   836 SEKGSKQ---QHKVHKYIMSCEMVMAPVHEAVVSLHISKVWDDISPQFYTTFWSLTMYDLAVPHT 897

  Fly   963 SYQREVAKLKQLAQQAAEGKDSNQSKNKKEQERYIALMEKLNDERKKQHEHVDKISQRLQEQKDS 1027
            ||:|||.|||...:...:.::...:|.|||:||..||.:||.:|.|||.|||.::..||:.:||:
Mouse   898 SYEREVNKLKIQMKAVDDSQEMPLNKKKKEKERCTALQDKLLEEEKKQTEHVQRVLHRLKLEKDN 962

  Fly  1028 WFLLRSGKSAKNDTITQFLQLCLFPRCTFTALDALYCAKFVHTIHNLKTSNFSTLLCYDRIFCDI 1092
            |.|   .||.||:|||:|||||:||||.|:|:|::|||.||..:|..||.||||||||||:|.||
Mouse   963 WLL---AKSTKNETITKFLQLCIFPRCIFSAIDSVYCAHFVELVHQQKTPNFSTLLCYDRVFSDI 1024

  Fly  1093 TYSVTSCTEGEATRYGRFLCAMLETVMRWHADQAVFNKECANYPGFVTKFRVSNQFSEAN--DHV 1155
            .|.|.|.||.||:|||||||.|||||.|||:|::.:.|||.|||||:|..|.:. |...|  |.:
Mouse  1025 IYMVASFTENEASRYGRFLCCMLETVTRWHSDRSTYEKECGNYPGFLTILRATG-FDGGNKADQL 1088

  Fly  1156 GYENYRHVCHKWHYKITKAIVFCLDSKDFMQIRNALIILMRILPHYPVLSKLAQIIERKVDKVRE 1220
            .|||:|||.||||||:|||.|.||::.::..|||.||:|.:|||.||.:..|.|.:||:|.|:.:
Mouse  1089 DYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVHKICQ 1153

  Fly  1221 EEKTKRPDLYAIASSYIGQLKLKTPHMLKESVFHQIAERPNKES------------PTSVG---- 1269
            |||.|:|||||:|..|.||||.:..:|:.|:.||.....|...:            |:|:|
Mouse  1154 EEKEKKPDLYALAMVYSGQLKSRKSYMIPENEFHHKDPPPRNTATNLQPSGPCSGLPSSIGSMCK 1218

  Fly  1270 ---------------APAAATRSDKLSPTSPSGN-TQGTRAPGGAAPFYNSEQKSVIKEPDAKAA 1318
                           |..|...::|.|..:|.|| :.|.......|...|.::|...||.:.|..
Mouse  1219 LDESSAEEADKSRERAQCAVKAANKASSVTPKGNLSNGNSGSNSKAVKENDKEKGKEKEKEKKEK 1283

  Fly  1319 STT---------------------------RES---------------KSQRGEGNNVTLVSTAT 1341
            :..                           ||:               |.::.:.....::....
Mouse  1284 TPAVTPEARVLGKDSKEKPKEEQPNKDEKIREAKERMPKSDKDKEKLKKEEKAKDEKFRIIVANV 1348

  Fly  1342 STASNNERE-----SKQRDLPAPRESQSRSKDDQQEQANNGSNGSRQSESRNRDV---ERDRHDQ 1398
            .:.|..|||     ||:|||....:|:...|..::...    :||.:|.....|:   ||::..:
Mouse  1349 ESKSTQEREKEKEPSKERDLAKEMKSKENVKGGEKAPV----SGSLKSPISRTDITEPEREKRRK 1409

  Fly  1399 QDQRSISSHRSS-RD-IVRVKERTEAELH--------QRSRER---SQRLEELEAQQRKREKTSR 1450
            .|.....||.|: :| :|::|| :.|:|:        .:|:||   .:.|::...:.|:|||...
Mouse  1410 VDSHPSPSHSSTIKDSLVKLKE-SSAKLYINHIPPLLCKSKEREADKKDLDKSRERSREREKKEE 1473

  Fly  1451 RGGEERIR---HGDGVETVDLVGSTDNRHYEEFEGRMRDLSSVSNESNGSLHHRQRSHETIEFEK 1512
            :..:||.|   :.|....:||:            .|.:|.:.:...|.   |..:...|::...:
Mouse  1474 KDRKERKRDYSNNDREAPLDLI------------KRRKDENGILGVSK---HKSESPCESLYPNE 1523

  Fly  1513 VDSKRRKLESSTSSSKKVEELVDSVKKARALKTKERNKDKLSDEERDARKDRKLGRKRDRVDESN 1577
            .|.::.|   |.||.|   |..||.|..:.        ||:|..::::..|::...|:::.|.|.
Mouse  1524 KDKEKMK---SKSSGK---EKGDSFKPEKI--------DKISSGKKESGHDKEKIEKKEKWDGSG 1574

  Fly  1578 SNEHKRRREGQNGEEELRDRERHR 1601
            ..|.|:..         :..::||
Mouse  1575 DKEEKKHH---------KTSDKHR 1589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tho2	NP_608646.3	THOC2_N	133..627	CDD:292752	198/502 (39%)
		Thoc2	629..703	CDD:288568	45/73 (62%)
		Tho2	939..1240	CDD:288156	171/302 (57%)
		PRP38_assoc	1570..1639	CDD:289628	6/32 (19%)
Thoc2l	NP_001160053.1	THOC2_N	13..566	CDD:406523	215/573 (38%)
		Thoc2	568..642	CDD:403051	45/73 (62%)
		Tho2	874..1173	CDD:402722	171/302 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850312
Domainoid	1	1.000	378	1.000	Domainoid score	I853
eggNOG	1	0.900	-	-		E1_KOG1874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1163	1.000	Inparanoid score	I204
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55273
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003449
OrthoInspector	1	1.000	-	-		otm43092
orthoMCL	1	0.900	-	-		OOG6_102850
Panther	1	1.100	-	-	O	PTHR21597
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3684
SonicParanoid	1	1.000	-	-		X2346
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790