DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment erm and Zbtb49

DIOPT Version :9

Sequence 1:	NP_001259891.2	Gene:	erm / 326152	FlyBaseID:	FBgn0031375	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_083438.1	Gene:	Zbtb49 / 75079	MGIID:	1922329	Length:	756	Species:	Mus musculus

Alignment Length:	695	Identity:	176/695 - (25%)
Similarity:	264/695 - (37%)	Gaps:	179/695 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YFSPRGMQPCSPAGEIAMMPPSKSPV-MESAASEQNPAQQSQQQDEQSAKRACPLKFSIAKIMEP 66
            ::.|..:|.|...|     |.:|.|. :.:.|...|.::.::.....:|..:||    .....:|
Mouse   150 HYPPPSLQECPVEG-----PQAKVPAEVNARAPSANFSRPTEVSKPDAAGGSCP----ELPCKQP 205

  Fly    67 DHR-----------------PSQVP-PPQPAPVSFATNDDDEDEDPEIDADSERSCSPIEVISLD 113
            :|.                 ||||| ..||...|.:|:....|..|.::.      .|..:.:.:
Mouse   206 NHYYKLRTLYSKQYYKQTACPSQVPATQQPLTRSASTDLAAADSQPPVEG------RPAVLETPE 264

  Fly   114 QSPSTVNYDSAFKKYVPGPC-SGATSSVASPPSTAAVQQFVSSRHQELLSQYPLLYYAPNQLMCA 177
            ..|||         :|..|. :....|.|.|                 ||:.|
Mouse   265 HLPST---------FVAPPVRNSGNDSEADP-----------------LSEPP------------ 291

  Fly   178 AAAAQYAALTAQQQSLASAAHLSSFTASLNASLHHSQSLRRNLGHP-----LAAAAAVAAVAQSQ 237
                      |:|..|..|.||...      :...||.......||     ||.....||...:.
Mouse   292 ----------AKQMRLKKAMHLKKL------NFLKSQQSAECTSHPEPDNGLARREESAAKEDAV 340

  Fly   238 AVPNLQHTLEK-----SPVAQRTAQSSGLQANLKRKRSPQDQGEVTPPPASTATSATGARSRSPS 297
            .....|...||     .|.:.|..:..|..|      |.:|..:...|....|....|...:.||
Mouse   341 ERAGSQTAEEKGRGELGPESSREEELPGAPA------SWEDPSQALQPQKQYACELCGKPFKHPS 399

  Fly   298 PQGSIEDSSPGSASGGKPKTFSCLECGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLC 362
               ::| ....|.:|.||  |.|..|||.|:...||..|:..|:|.:|::|::|||.|..:..:.
Mouse   400 ---NLE-LHKRSHTGEKP--FECNICGKHFSQAGNLQTHLRRHSGEKPYICEICGKRFAASGDVQ 458

  Fly   363 RHKIIHTSEKPHKCQTCGKAFNRSSTLNTHSRIHAGYKPFVCEYCGKGFHQKGNYKNHKLTHSGE 427
            ||.|||:.||||.|.|||:.|:..|.|..|.:.|...|.|.|:.|||.|:.:.....|::.|:||
Mouse   459 RHIIIHSGEKPHLCDTCGRGFSNFSNLKEHKKTHTADKVFTCDECGKSFNMQRKLVKHRVRHTGE 523

  Fly   428 KAYKCNICNKAFHQVYNLTFHMHTHNDKKPYTCRVCAKGFCRNFDLKKHMRKLHEIGGDLDDLDM 492
            :.|.|..|.|.|....:|..|:.||..:|||:|.||:|.|.|:..|::| :::|   |..|
Mouse   524 RPYSCPACGKCFGGSGDLRRHVRTHTGEKPYSCEVCSKCFTRSAVLRRH-KRMH---GRAD---- 580

  Fly   493 PPTYDRRREYTRREPLASGYGQASGQLTP-----DSSSGSMSPPINVTTPPLSSGETSNPAWP-R 551
                       .|.|:.  .|:.|..:.|     ..||.|.|..::||..|:|   ...|..| .
Mouse   581 -----------ARSPVV--LGELSRPIEPSDLDRSQSSDSFSQDVSVTLMPVS---VKLPVQPVE 629

  Fly   552 SAVSQY----------------PPG-GFHHQLGVAP-----PHDYPSGSAFLQLQPQ-------Q 587
            |:|:.:                ||| ....:|.:.|     |.:       ||.|||       :
Mouse   630 SSVAGFDGHCSGSYCKLRSMLRPPGMSDQDRLSLEPSKLAKPPE-------LQSQPQAYAYSDVE 687

  Fly   588 PHPQSQQHHQQQQRLSETFIAKVFXQRYYAESLNSSTGSTSTTSS 632
            |....:|.......:|.:.:|.:  ..:..|.|.|...|.:..:|
Mouse   688 PSAGVEQPQADGMAVSRSSLATL--DNHCTEPLGSRAPSVTYRNS 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	65/165 (39%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		zf-H2C2_2	332..357	CDD:290200	11/24 (46%)
		zf-C2H2	346..368	CDD:278523	8/21 (38%)
		C2H2 Zn finger	348..368	CDD:275368	8/19 (42%)
		zf-H2C2_2	363..385	CDD:290200	14/21 (67%)
		C2H2 Zn finger	376..396	CDD:275368	8/19 (42%)
		zf-H2C2_2	389..413	CDD:290200	10/23 (43%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		zf-H2C2_2	416..441	CDD:290200	9/24 (38%)
		C2H2 Zn finger	432..452	CDD:275368	6/19 (32%)
		C2H2 Zn finger	460..478	CDD:275368	8/17 (47%)
Zbtb49	NP_083438.1	BTB	15..118	CDD:279045
		BTB	26..119	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..197		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..290		22/95 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..379		17/73 (23%)
		COG5048	<376..576	CDD:227381	76/206 (37%)
		zf-C2H2	386..408	CDD:278523	5/25 (20%)
		C2H2 Zn finger	388..408	CDD:275368	4/23 (17%)
		zf-H2C2_2	400..425	CDD:290200	11/27 (41%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		zf-H2C2_2	428..452	CDD:290200	10/23 (43%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		zf-H2C2_2	456..481	CDD:290200	14/24 (58%)
		C2H2 Zn finger	472..492	CDD:275368	8/19 (42%)
		zf-H2C2_2	484..508	CDD:290200	9/23 (39%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		zf-H2C2_2	513..535	CDD:290200	8/21 (38%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		zf-H2C2_2	540..565	CDD:290200	12/24 (50%)
		C2H2 Zn finger	556..576	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910