Protein Alignment erm and Zbtb33

DIOPT Version :10

• Sequence 1: NP_001259891.2
• Gene: erm / 326152
• FlyBaseID: FBgn0031375
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_064652.2
• Gene: Zbtb33 / 56805
• MGIID: 1927290
• Length: 671
• Species: Mus musculus
• Alignment Length: 613
• Identity: 127/613 - (20%)
• Similarity: 226/613 - (36%)
• Gaps: 189/613 - (30%)

  Fly    29 MESAASEQN-PAQQSQQQDEQSAKRACPLKFSIAKIMEPDHRPSQVPPPQPAPVSFATNDDDEDE 92
            :.|::|::: ..::|:.:.:.:.....|:......:...|:...::         ..|:.||:|:
Mouse   138 LPSSSSDKSLDMEKSKDEAQDNGATVMPIITESFSLSAEDNEMKKI---------IVTDSDDDDD 193

  Fly    93 DPEIDADSERSCSPIEVISLDQSPSTVNYDSAFKKYVPGPCSGATSSVA------SPPST----- 146
            |..|      .||.| :.:.:..||    ::...:..|.|.|.|.|.|.      |||.|
Mouse   194 DDVI------FCSEI-LPAKEDLPS----NNTATQVQPNPASVAISEVTPCASNNSPPVTNITPT 247

  Fly   147 ---AAVQQFVSSRHQ---ELLSQYPLLYYAPNQLMCAAAAAQYAALTAQQQSLASAA-HLSSFTA 204
               ..|.|...|:.|   |||......:..||.::     ...|.|||...:.:|.. |:||
Mouse   248 QLPTPVNQATLSQTQGSEELLVSSASTHLTPNIIL-----LNQAPLTAPPSASSSLPNHMSS--- 304

  Fly   205 SLNASLHHSQS-----LRRNLGH----------PLAAAAAVAAVAQSQAVPNLQH----TLEKS- 249
            |:|..:.:.|:     |..|...          .:.:::..:||:.:..||...:    ||:.|
Mouse   305 SVNVLVQNQQTPNSAVLTGNKAEEEEEIIDDDDDIISSSPDSAVSNTSLVPQADNSKSTTLDGSL 369

  Fly   250 ------PVAQRTAQSSGLQAN-----------LKRKRSPQDQGEVTPPPASTATS----ATGARS 293
                  ||..:...|:.|:.:           |:.|...:.|..:|   ..|||.    :||.:.
Mouse   370 TQKMQIPVLPQEPPSNSLKISDVITRNTNDPGLRSKHVMEGQKIIT---LDTATEIEGLSTGCKV 431

  Fly   294 RS--------------PSPQG---SIEDSSPGSASGGKPKTFSCLECGKV-FNAHYNLTRHMPVH 340
            .:              ..|.|   .:::..| ..||.:|..    :..|| .:.||.|     :.
Mouse   432 YANIGEDTYDIVIPVKDDPDGGEAKLDNELP-KTSGSEPPN----KRMKVKHDDHYEL-----IV 486

  Fly   341 TGARPFVCKVCGKGFRQASTLCRHKIIHTSEKPHKCQTCGKAFNRSSTLNTHSRIHAGYKPFVCE 405
            .|...::|.||.:.:...::|.||..||:.||.::|:.|.|.|.                  :.|
Mouse   487 DGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYQCRYCDKVFP------------------LAE 533

  Fly   406 YCGKGFHQKGNYKNHKLTHSGEKAYKCNICNKAFHQVYNLTFH---MHTHN---DKKPYTCRVCA 464
            |..|          |::.|:||:.|:|..|.|:|.....::.|   :|:.:   |.|.|....
Mouse   534 YRTK----------HEIHHTGERRYQCLTCGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHP-- 586

  Fly   465 KGFCRNFDLKKHMRKLHEIGGDLDDLDMPPTYDRRREYTRREPLASGYGQASGQLTPDSSSGSMS 529
               |::..::::....::...      ||...|.          |.||...:|:          .
Mouse   587 ---CKSLQIRQYAYLSNKSSA------MPVMKDD----------AVGYKVDAGK----------E 622

  Fly   530 PPINVT-TPPLSSGETSNPAWPRSAVSQ 556
            ||:..| |||    :..:..|....:.|
Mouse   623 PPVGTTSTPP----QNKSTFWEDIFIQQ 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	43/189 (23%)
		C2H2 Zn finger	320..340	CDD:275368	5/20 (25%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		zf-H2C2_2	363..385	CDD:463886	10/21 (48%)
		C2H2 Zn finger	376..396	CDD:275368	4/19 (21%)
		C2H2 Zn finger	404..424	CDD:275368	4/19 (21%)
		C2H2 Zn finger	432..452	CDD:275368	6/22 (27%)
		C2H2 Zn finger	460..478	CDD:275368	1/17 (6%)
Zbtb33	NP_064652.2	Self-association	1..136
		Interaction with NCOR1. /evidence=ECO:0000250	1..103
		BTB_POZ_ZBTB33_KAISO	11..116	CDD:349528
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..161		3/22 (14%)
		Interaction with CBFA2T3. /evidence=ECO:0000250|UniProtKB:Q86T24	298..571		67/316 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..365		4/32 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..474		5/27 (19%)
		Interaction with CTNND1	452..671		58/268 (22%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:15564377	469..478		3/12 (25%)
		C2H2 Zn finger	494..514	CDD:275368	6/19 (32%)
		zf-H2C2_2	506..529	CDD:463886	10/22 (45%)
		Required for DNA-binding	512..637		39/187 (21%)
		C2H2 Zn finger	522..542	CDD:275368	8/47 (17%)
		zf-H2C2_2	537..559	CDD:463886	10/31 (32%)
		C2H2 Zn finger	550..571	CDD:275368	5/20 (25%)