DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment erm and ZNF444

DIOPT Version :9

Sequence 1:	NP_001259891.2	Gene:	erm / 326152	FlyBaseID:	FBgn0031375	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_060807.2	Gene:	ZNF444 / 55311	HGNCID:	16052	Length:	327	Species:	Homo sapiens

Alignment Length:	192	Identity:	66/192 - (34%)
Similarity:	83/192 - (43%)	Gaps:	39/192 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 RSPQDQGEVTPPPAST-----------ATSATGARSRSPSPQGSI-----EDSSPGSASG----- 312
            |.|||   ||..|.:|           |.:|.||...:|....::     |.|||..|.|
Human   112 RVPQD---VTQGPGATGGKEDSGMIPLAGTAPGAEGPAPGDSQAVRPYKQEPSSPPLAPGLPAFL 173

  Fly   313 GKPKTFSCLECGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIH--------- 368
            ..|.|.||.||||......:|.||...|:|.:|..|..|||.||:...|.||:..|
Human   174 AAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGSPGSPGP 238

  Fly   369 ------TSEKPHKCQTCGKAFNRSSTLNTHSRIHAGYKPFVCEYCGKGFHQKGNYKNHKLTH 424
                  ..||||.|..|||.|.....|..|.:.|:|.:||.|..|||||.::.:...|:..|
Human   239 ALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIH 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	54/155 (35%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		zf-H2C2_2	332..357	CDD:290200	11/24 (46%)
		zf-C2H2	346..368	CDD:278523	9/21 (43%)
		C2H2 Zn finger	348..368	CDD:275368	9/19 (47%)
		zf-H2C2_2	363..385	CDD:290200	12/36 (33%)
		C2H2 Zn finger	376..396	CDD:275368	7/19 (37%)
		zf-H2C2_2	389..413	CDD:290200	12/23 (52%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		zf-H2C2_2	416..441	CDD:290200	2/9 (22%)
		C2H2 Zn finger	432..452	CDD:275368
		C2H2 Zn finger	460..478	CDD:275368
ZNF444	NP_060807.2	SCAN	21..98	CDD:366881
		PRK14959	<60..>182	CDD:184923	22/72 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..171		19/61 (31%)
		COG5048	<179..>280	CDD:227381	37/100 (37%)
		C2H2 Zn finger	181..201	CDD:275368	8/19 (42%)
		C2H2 Zn finger	209..229	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..243		4/22 (18%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		zf-C2H2	278..300	CDD:333835	8/21 (38%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910