DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment erm and CG12071

DIOPT Version :9

Sequence 1:	NP_001259891.2	Gene:	erm / 326152	FlyBaseID:	FBgn0031375	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_651832.3	Gene:	CG12071 / 43660	FlyBaseID:	FBgn0039808	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	101/471 - (21%)
Similarity:	154/471 - (32%)	Gaps:	126/471 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 ASLNASLHHSQSLRRNLGHPLAAAAAVAAVAQSQAVPNLQHTLEKSPVA--QRTAQSSGLQANLK 266
            |..||.|....::::.:        |.||:...|...:.|   :.||.|  ...:|::|   |::
  Fly     7 AQKNAYLEAHMAVQQQM--------AQAAIQFKQQQTSQQ---QNSPTANNNNNSQNNG---NMQ 57

  Fly   267 RKRSPQDQGE---------------VTPPPASTATSATGARSRSPSPQGSIEDSSPGSASGGKPK 316
            :::..|.|.:               :..|..|::..|..|...|..   ::.|...|...|.:
  Fly    58 QQQQQQQQQQQQQQQQQQQQHYAATIKVPQISSSNVAAAAAGESTF---TVPDDGMGFEGGVR-- 117

  Fly   317 TFSCLECGKVFNAHYNLTRHMPVHTGARPFV-CKVCGKGFRQASTLCRHKIIHTSEKPHKCQTCG 380
               .|:....::|...||.::| .....||. ..|.|.....||.|      ...::..:..:..
  Fly   118 ---VLQSLGTWSAAEQLTYNIP-KPNLIPFTEPYVEGGSMHPASRL------KALQQVQQASSGV 172

  Fly   381 KAFNRSSTLNTHSRIHAGYKPFVCEYCGKGFHQKGNYKNHKLTHSGEKAYKCNICNKAFHQVYNL 445
            :..|.|.:.|         |.|.|..||||..:|.....|...|:|||.|.|.:|||||.:...|
  Fly   173 RKTNPSKSTN---------KAFECTVCGKGLARKDKLTIHMRIHTGEKPYICEVCNKAFARRDKL 228

  Fly   446 TFHMHTHNDKKPYTCRVCAKGFCRNFDLKKHMRKLHEIGGDLDDLDMPPTYDRRREYTRR----- 505
            ..||:......|.......|.. .|...||....             ||..|.::....:
  Fly   229 VIHMNKFKHVTPTNIAPLGKRL-NNMVKKKEQPD-------------PPPEDNKQSLELQLQQQA 279

  Fly   506 -EPLASGYGQASGQLTPDSSSGSMSP-----------------------------PINVTTPPLS 540
             :..|......|.|..|.|..|.:.|                             .:.. .|...
  Fly   280 VQVAAQNIIVQSAQGAPTSIPGIIIPHHQQQLSWTCELCGRMFSSRDEWSIHAKSHLEYXQPERL 344

  Fly   541 SGETSNPAWPRSAV----------SQYPPGGFHHQLG----------VAPPHDYPSGSAFLQLQP 585
            ..|::.||...:.|          ..|......:|:.          :.......:.|...|.||
  Fly   345 VAESTKPAAAAAGVIAKTTSSNNSRNYQMDANQNQIQMEAQARKQKIIIQNQMILNASHQQQQQP 409

  Fly   586 QQPHPQSQQHHQQQQR 601
            || |||.|||.||||:
  Fly   410 QQ-HPQQQQHQQQQQQ 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	43/166 (26%)
		C2H2 Zn finger	320..340	CDD:275368	5/19 (26%)
		zf-H2C2_2	332..357	CDD:290200	7/25 (28%)
		zf-C2H2	346..368	CDD:278523	6/22 (27%)
		C2H2 Zn finger	348..368	CDD:275368	5/19 (26%)
		zf-H2C2_2	363..385	CDD:290200	0/21 (0%)
		C2H2 Zn finger	376..396	CDD:275368	3/19 (16%)
		zf-H2C2_2	389..413	CDD:290200	8/23 (35%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		zf-H2C2_2	416..441	CDD:290200	12/24 (50%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
		C2H2 Zn finger	460..478	CDD:275368	4/17 (24%)
CG12071	NP_651832.3	zf-C2H2	185..207	CDD:278523	8/21 (38%)
		C2H2 Zn finger	187..207	CDD:275368	7/19 (37%)
		zf-H2C2_2	200..224	CDD:290200	12/23 (52%)
		C2H2 Zn finger	215..232	CDD:275368	7/16 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100