DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment erm and ich

DIOPT Version :9

Sequence 1:	NP_001259891.2	Gene:	erm / 326152	FlyBaseID:	FBgn0031375	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_001262393.1	Gene:	ich / 41069	FlyBaseID:	FBgn0286204	Length:	592	Species:	Drosophila melanogaster

Alignment Length:	370	Identity:	81/370 - (21%)
Similarity:	131/370 - (35%)	Gaps:	92/370 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 NDDDEDEDPEIDADSERSCSPIEVISLDQSPSTVNYDSAFKKYV----PGPCSGATSSVASPPST 146
            |:|..|...::||..:.:|     |..:.:...|:...:...::    |.|...::|:
  Fly   278 NNDTRDSWMDLDAWIDGNC-----IQQESAKVLVSQQDSLGDFILPHSPLPMHASSST------- 330

  Fly   147 AAVQQFVSSRHQELLSQYPLLYYAP---NQLMCAAAAAQYAALTAQQQSLASAAHLSSFTASLNA 208
              :|..:|..:..||..  .|...|   |.......|.|.|.:....|:..|.::.:...|:.::
  Fly   331 --LQSLLSHGYMPLLQN--RLQNGPPNGNSSGGGGGANQGAGIKGDPQAPTSTSYCNELAAATSS 391

  Fly   209 SLHHSQSLRRNLGHP---LAAAAAVAAVAQSQAVPNLQHTLEKSPVAQRTAQSSGLQANLKRKRS 270
            |.....|:.....:|   :.....::....:||..||...      ...:.|:|||        |
  Fly   392 SCSPPGSVVSTTDNPNGLMINPRYLSNPTNNQATGNLHQQ------GGYSMQASGL--------S 442

  Fly   271 PQDQGEVTPP-----PASTATSATGARSRSPSPQGSIEDSSPGS---------------ASGGKP 315
            .:|.|..:|.     |.:|..|.||:..|:.:|:.....|...|               ..||:|
  Fly   443 LKDNGLCSPDLLGNYPHTTTASTTGSEMRTGAPKAKRSRSQKKSNQQQQQQQQQQQQQGDGGGQP 507

  Fly   316 KTFSCLECGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTSEKP-HKCQTC 379
            .|                           |.:..:...|| .||.|..   :...||| |:|..|
  Fly   508 TT---------------------------PQMSAISPSGF-SASDLSG---LLGKEKPVHRCSIC 541

  Fly   380 GKAFNRSSTLNTHSRIHAGYKPFVCEYCGKGFHQKGNYKNHKLTH 424
            .:.|...|.:..|.|.|.|.|||.|:.|.|.|.||.:...|:..|
  Fly   542 NRGFLNKSNIKVHLRTHTGEKPFRCDVCAKAFRQKAHLLKHQQIH 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	36/146 (25%)
		C2H2 Zn finger	320..340	CDD:275368	0/19 (0%)
		zf-H2C2_2	332..357	CDD:290200	3/24 (13%)
		zf-C2H2	346..368	CDD:278523	5/21 (24%)
		C2H2 Zn finger	348..368	CDD:275368	5/19 (26%)
		zf-H2C2_2	363..385	CDD:290200	7/22 (32%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		zf-H2C2_2	389..413	CDD:290200	11/23 (48%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		zf-H2C2_2	416..441	CDD:290200	2/9 (22%)
		C2H2 Zn finger	432..452	CDD:275368
		C2H2 Zn finger	460..478	CDD:275368
ich	NP_001262393.1	C2H2 Zn finger	538..558	CDD:275368	6/19 (32%)
		zf-H2C2_2	550..575	CDD:316026	11/24 (46%)
		C2H2 Zn finger	566..586	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100