DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment erm and CG1602

DIOPT Version :9

Sequence 1:NP_001259891.2 Gene:erm / 326152 FlyBaseID:FBgn0031375 Length:698 Species:Drosophila melanogaster
Sequence 2:NP_610291.2 Gene:CG1602 / 35684 FlyBaseID:FBgn0033186 Length:577 Species:Drosophila melanogaster


Alignment Length:594 Identity:127/594 - (21%)
Similarity:210/594 - (35%) Gaps:186/594 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 VYFSPRGMQ-PCSPAGEIA-----MMPPSKSPVMESAASEQNPAQQSQQQDEQSAKRACPLKFSI 60
            |:...|.|: ...|.||.:     :.||.:.|          .|::|..|.::||..|| ::..|
  Fly    42 VHSKVRSMEDDFEPVGENSTESGHVDPPEEKP----------QAEESIFQQDESADGAC-VQLHI 95

  Fly    61 AKIMEPDHRPSQVPPPQPAPVSFATNDDD--EDEDPEIDADSERSCSPIEVISLDQSPSTVNYDS 123
                  |...|.....:.:.||..|::::  :||||...|        ::..:|..:|:...:.|
  Fly    96 ------DAVRSSTNETEESDVSLVTDEEESVQDEDPSEPA--------LDDANLKTTPTYKFHPS 146

  Fly   124 AFKK----------YVPGPC--SGATSSVASPPS------------TAAVQQFVSSR-------- 156
            .|::          |...||  :.|.|....|..            .|.|..|::..        
  Fly   147 FFRRDHRTIKFIEIYKEHPCLWNPAHSDYKEPKKCKEALKRMAIDLEATVSVFLNEMALKLAIKK 211

  Fly   157 --------HQELLS--QYP-LLYYAPNQLMC-AAAAAQYAALTAQQQSLASAAHLSSFTASL--- 206
                    |:.::|  |.| .|.::..:|.| ..|:......|..::.....:..:..|..|   
  Fly   212 VHMQFNTVHKRVVSGKQKPQSLAFSIYKLCCFLNASNDEEGATNNEKIKLDFSKKNKLTTDLIEM 276

  Fly   207 ----------NASLHHSQSLRRNLGHPLAAAAAVAAVAQS-----QAVPNLQHTLEKSP----VA 252
                      |.....:.|.|:.....:||..:|..|..:     :|:.||:....|:.    .|
  Fly   277 YANFPQLYDSNHKEFSNMSSRKQAYESMAAEISVPNVDINSDDIFRAIQNLRQWYYKNTKHAIYA 341

  Fly   253 QRTAQSSGLQ------ANLKRKRSPQDQGEVTPPPASTATSATGARSRSPSPQGSIEDSSPGSAS 311
            ..||:...|:      |.:.::|                                          
  Fly   342 GSTAEKFYLEVCRFMPAKMYKQR------------------------------------------ 364

  Fly   312 GGKPKTFSCLECGKVFNAHYNLTRHM-PVHT-GARPFVCKVCGKGFRQASTLCRH-KIIHTSEKP 373
                  ..|..|.::.::.:.|..|: ..|. |..||.|.:|.:.|.....|..| :.:|.. |.
  Fly   365 ------LVCEFCHQITSSDHVLQSHIFKAHNIGELPFKCTLCDRSFVGRCELANHIQRVHIG-KT 422

  Fly   374 HKCQTCGKAFNRSSTLNTHSRIHAGYKPFVCEYCGKGFHQKGNYKNH-KLTHSGEKAYKCNICNK 437
            |||..|.::|...|.|..|.|.|.|:||:|||:|||.|..:.....| ...|:..:|:||.:|.|
  Fly   423 HKCTHCERSFAVMSDLQLHIRTHTGHKPYVCEHCGKAFRLRSQMTLHVTAIHTKIRAFKCTMCPK 487

  Fly   438 AFHQVYNLTFHMHTHNDKKPYTCRVCAKGF--------------------CRNFD--------LK 474
            .|.:..:|:.|:..|.:.:...|.||.|||                    |:..|        |.
  Fly   488 DFVKKVDLSDHIKGHLNIRDKICSVCGKGFTSCHALIRHRQIHSEVKKFVCKLCDSRFSQFVGLN 552

  Fly   475 KHMRKLHEI 483
            .||::.|.|
  Fly   553 THMKRTHNI 561

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ermNP_001259891.2 COG5048 <295..461 CDD:227381 46/169 (27%)
C2H2 Zn finger 320..340 CDD:275368 4/20 (20%)
zf-H2C2_2 332..357 CDD:290200 9/26 (35%)
zf-C2H2 346..368 CDD:278523 6/22 (27%)
C2H2 Zn finger 348..368 CDD:275368 5/20 (25%)
zf-H2C2_2 363..385 CDD:290200 8/22 (36%)
C2H2 Zn finger 376..396 CDD:275368 7/19 (37%)
zf-H2C2_2 389..413 CDD:290200 14/23 (61%)
C2H2 Zn finger 404..424 CDD:275368 7/20 (35%)
zf-H2C2_2 416..441 CDD:290200 8/25 (32%)
C2H2 Zn finger 432..452 CDD:275368 6/19 (32%)
C2H2 Zn finger 460..478 CDD:275368 10/45 (22%)
CG1602NP_610291.2 GT1 157..244 CDD:304916 16/86 (19%)
MADF_DNA_bdg 273..356 CDD:287510 16/82 (20%)
C2H2 Zn finger 367..388 CDD:275368 4/20 (20%)
C2H2 Zn finger 397..418 CDD:275368 5/20 (25%)
COG5048 <423..554 CDD:227381 40/130 (31%)
C2H2 Zn finger 425..445 CDD:275368 7/19 (37%)
zf-H2C2_2 437..460 CDD:290200 13/22 (59%)
C2H2 Zn finger 453..470 CDD:275368 6/16 (38%)
C2H2 Zn finger 482..502 CDD:275368 6/19 (32%)
C2H2 Zn finger 510..530 CDD:275368 6/19 (32%)
C2H2 Zn finger 538..559 CDD:275368 5/20 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24393
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
11.100

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