DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment erm and ZNF500

DIOPT Version :9

Sequence 1:NP_001259891.2 Gene:erm / 326152 FlyBaseID:FBgn0031375 Length:698 Species:Drosophila melanogaster
Sequence 2:NP_067678.1 Gene:ZNF500 / 26048 HGNCID:23716 Length:480 Species:Homo sapiens


Alignment Length:532 Identity:144/532 - (27%)
Similarity:196/532 - (36%) Gaps:154/532 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 VPPPQPAPVSFATNDDDEDEDPEIDADSERSCSPIEVISLDQSPSTVNYDSAFKKY----VPGP- 132
            ||..||.|   ....|.|.|:..|....|..|...|.....:.||...:...|:.:    |.|| 
Human     4 VPGLQPLP---TLEQDLEQEEILIVKVEEDFCLEEEPSVETEDPSPETFRQLFRLFCYQEVAGPR 65

  Fly   133 ----------CSGATSSVASPP---STAAVQQFVS------------------------------ 154
                      |......:.:..   ....::||::                              
Human    66 EALSRLWELCCRWLRPELRTKEQILELLVLEQFLTVLPGEIQARVREQQPESGEEAVVLVEGLQR 130

  Fly   155 ------SRHQELLSQYPLLYYAPNQLMCAAAAAQYAALTAQQQSLASA----AHLSSFTASLNAS 209
                  .|..||||...:......|.:...|.||...|:.::::..|:    |.||         
Human   131 KPRKHRQRGSELLSDDEVPLGIGGQFLKHQAEAQPEDLSLEEEARFSSQQPPAQLS--------- 186

  Fly   210 LHHSQS---LRRNLG-----HPLAAAAAVAAVAQSQAVPNLQ----HTLEKSP----VAQRTA-- 256
             |..|.   |....|     |...|:|:....|.||...||:    :...:.|    .|||.|  
Human   187 -HRPQRGPLLWPERGPPAPRHQEMASASPFLSAWSQVPVNLEDVAVYLSGEEPRCMDPAQRDAPL 250

  Fly   257 --QSSGLQ----------ANLK----RKRSPQDQGEVTPPPASTATSATGARSRSPSPQGSIEDS 305
              :..|:|          |.|:    |..|.:.||...|.|........|. .|...|:|.   .
Human   251 ENEGPGIQLEDGGDGREDAPLRMEWYRVLSARCQGPGHPLPGQRPAPVRGL-VRPDQPRGG---P 311

  Fly   306 SPG-SASGGKPKTFSCLECGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHT 369
            .|| .||.|..|.::|.||||.|:...:||:|...|||.||:.|.||||||...|....|:.:||
Human   312 PPGRRASHGADKPYTCPECGKGFSKTSHLTKHQRTHTGERPYKCLVCGKGFSDRSNFSTHQRVHT 376

  Fly   370 SEKPHKCQTCGKAFNRSSTLNTHSRIHAGYKPFVCEYCGKGFHQKGNYKNHKLTHSGEKAYKCNI 434
            .|||:.|..|||.|::||:|..|.|.|:|.:|:.|..|||.|:...::..|:.||:||       
Human   377 GEKPYPCPECGKRFSQSSSLVIHRRTHSGERPYACTQCGKRFNNSSHFSAHRRTHTGE------- 434

  Fly   435 CNKAFHQVYNLTFHMHTHNDKKPYTCRVCAKGFCRNFDLKKHMRKLHEIGGDLDDLDMPPTYDRR 499
                                 |||||..|.:||.|..||.||.| .|...|.|..|         
Human   435 ---------------------KPYTCPACGRGFRRGTDLHKHQR-THMGAGSLPTL--------- 468

  Fly   500 REYTRREPLASG 511
                  :|:|.|
Human   469 ------QPVAPG 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ermNP_001259891.2 COG5048 <295..461 CDD:227381 63/166 (38%)
C2H2 Zn finger 320..340 CDD:275368 9/19 (47%)
zf-H2C2_2 332..357 CDD:290200 15/24 (63%)
zf-C2H2 346..368 CDD:278523 9/21 (43%)
C2H2 Zn finger 348..368 CDD:275368 9/19 (47%)
zf-H2C2_2 363..385 CDD:290200 11/21 (52%)
C2H2 Zn finger 376..396 CDD:275368 10/19 (53%)
zf-H2C2_2 389..413 CDD:290200 11/23 (48%)
C2H2 Zn finger 404..424 CDD:275368 6/19 (32%)
zf-H2C2_2 416..441 CDD:290200 5/24 (21%)
C2H2 Zn finger 432..452 CDD:275368 0/19 (0%)
C2H2 Zn finger 460..478 CDD:275368 9/17 (53%)
ZNF500NP_067678.1 SCAN 46..151 CDD:128708 12/104 (12%)
SCAN 46..134 CDD:280241 7/87 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..208 13/56 (23%)
KRAB_A-box 224..>247 CDD:143639 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..268 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 284..322 13/41 (32%)
COG5048 <320..459 CDD:227381 67/167 (40%)
zf-C2H2 325..347 CDD:278523 9/21 (43%)
C2H2 Zn finger 327..347 CDD:275368 9/19 (47%)
zf-H2C2_2 339..363 CDD:290200 14/23 (61%)
C2H2 Zn finger 355..375 CDD:275368 9/19 (47%)
zf-H2C2_2 367..392 CDD:290200 11/24 (46%)
C2H2 Zn finger 383..403 CDD:275368 10/19 (53%)
zf-H2C2_2 395..420 CDD:290200 11/24 (46%)
C2H2 Zn finger 411..431 CDD:275368 6/19 (32%)
zf-H2C2_2 423..448 CDD:290200 13/52 (25%)
C2H2 Zn finger 439..459 CDD:275368 10/20 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 453..480 10/38 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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