Protein Alignment erm and ZNF683

DIOPT Version :10

• Sequence 1: NP_001259891.2
• Gene: erm / 326152
• FlyBaseID: FBgn0031375
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: XP_006710618.1
• Gene: ZNF683 / 257101
• HGNCID: 28495
• Length: 533
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 135/560 - (24%)
• Similarity: 194/560 - (34%)
• Gaps: 165/560 - (29%)

  Fly    54 CPLKFS------IAKIMEPDHRPSQVPPPQPAPVSFATNDDDED------EDPEIDADSERSCSP 106
            |||..:      :|.:.:.|   ..:..|||||:........||      |.|.:.|.
Human    71 CPLPLAPGRSALLACLQDLD---LNLCTPQPAPLGTDLQGLQEDALSMKHEPPGLQAS------- 125

  Fly   107 IEVISLDQSPSTVNYDSAFKKY----------VPGPCSGATSSVASPP----STAAVQQF----- 152
                |.|....||.|.....|.          .|.|...:.:|.:.||    .:.:...|
Human   126 ----STDDKKFTVKYPQNKDKLGKQPERAGEGAPCPAFSSHNSSSPPPLQNRKSPSPLAFCPCPP 186

  Fly   153 VSSRHQEL-------LSQYPLLYYAPNQLMCAAAAAQYAALTAQQQSLASAAHLSSFTASLNASL 210
            |:|..:||       ...||||...|                          ||.::.|..:...
Human   187 VNSISKELPFLLHAFYPGYPLLLPPP--------------------------HLFTYGALPSDQC 225

  Fly   211 HHSQSLRRNLGHPLAAAAAVAAVAQSQAVPNLQ-HTLEKSPVAQRTAQSSGLQANLKRKRSPQDQ 274
            .|...|.::..:|..|..::..:......|:.: .||...|.|   .|:|| ||...:.|:|...
Human   226 PHLLMLPQDPSYPTMAMPSLLMMVNELGHPSARWETLLPYPGA---FQASG-QALPSQARNPGAG 286

  Fly   275 GEVTPPPASTATSATGARSRSP--SPQGSIEDSSPGSASGGKPKTFSCLECGKVFNAHYNLTRHM 337
            ...|..|............|.|  |..|:.....|.....|| ..:.|..|||.|....||..|:
Human   287 AAPTDSPGLERGGMASPAKRVPLSSQTGTAALPYPLKKKNGK-ILYECNICGKSFGQLSNLKVHL 350

  Fly   338 PVHTGARPFVCKVCGKGFRQASTLCRHKIIHTSEKPHKC--------------------QTCGKA 382
            .||:|.|||.|.:|.|.|.|.:.|.:|.::||.|:||||                    :.|.|.
Human   351 RVHSGERPFQCALCQKSFTQLAHLQKHHLVHTGERPHKCSIPWVPGRNHWKSFQAWREREVCHKR 415

  Fly   383 FNRSSTLNTHSRIHAGYKPFVCEYCGKGFHQKGNYKNHKLTHSGEKAYKCNICNKAFHQVYNLTF 447
            |:.||.|.||.|:|:|.:||.|..|...|.|..:.|.|...|:.:   .|.:
Human   416 FSSSSNLKTHLRLHSGARPFQCSVCRSRFTQHIHLKLHHRLHAPQ---PCGL------------- 464

  Fly   448 HMHTHNDKKPYTCRVC-AKGFCRNFDL-----KKHMRKLHEIGGDLDDLDMPPTYDRRREYTRRE 506
             :||   :.|.....| |:......||     :|||      |.|:|::.:..|
Human   465 -VHT---QLPLASLACLAQWHQGALDLMAVASEKHM------GYDIDEVKVSST----------- 508

  Fly   507 PLASGYGQASGQLTPDSSSGSMSPPINVTTPPLSSGETSN 546
                  .|...:....||:|:          ||..|:..|
Human   509 ------SQGKARAVSLSSAGT----------PLVMGQDQN 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	58/187 (31%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		zf-H2C2_2	363..385	CDD:463886	11/41 (27%)
		C2H2 Zn finger	376..396	CDD:275368	10/39 (26%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		C2H2 Zn finger	432..452	CDD:275368	2/19 (11%)
		C2H2 Zn finger	460..478	CDD:275368	6/23 (26%)
ZNF683	XP_006710618.1	zf-C2H2	331..353	CDD:395048	8/21 (38%)
		C2H2 Zn finger	333..353	CDD:275368	8/19 (42%)
		zf-H2C2_2	345..370	CDD:463886	13/24 (54%)
		C2H2 Zn finger	361..381	CDD:275368	7/19 (37%)
		C2H2 Zn finger	389..429	CDD:275368	10/39 (26%)
		zf-H2C2_2	421..446	CDD:463886	11/24 (46%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)