DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment erm and Zfp648

DIOPT Version :9

Sequence 1:	NP_001259891.2	Gene:	erm / 326152	FlyBaseID:	FBgn0031375	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	XP_008767911.2	Gene:	Zfp648 / 100362915	RGDID:	2323778	Length:	534	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	139/578 - (24%)
Similarity:	198/578 - (34%)	Gaps:	181/578 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SPVMESAASEQNPAQQSQQQDEQSA--KRACPLKFSIAKIMEPDHRPSQVPPPQPAPVSFATND- 87
            |||.::....|...|..:::|..|.  :..|           .:.||.::|.        .||:
  Rat    41 SPVTQNNTDLQFDTQSCKEEDNWSECFRAGC-----------VEQRPGKIPR--------KTNNW 86

  Fly    88 --------DDEDEDPEIDADSERSCSPIEVISLDQSPSTVNYDSAFKKYVPGPCSGATSSVASPP 144
                    ..:|.....:|....|.|.:..:.:.....:|..|.. ||....|.|.|.:|.....
  Rat    87 GGRGWRITQTQDSPGLQEALGAPSRSFLYKVQMQPLRDSVGSDRV-KKENKDPASEALTSFLDTG 150

  Fly   145 STAAVQQFV--SSRHQELLSQYPLLYYAPNQLMCAAAAAQYAALTAQQQSLASAAHLSSFTASLN 207
            .:...|..:  ||..:..|..:|.....|                         |..||..|.|.
  Rat   151 GSFGTQNSLEASSLDKNSLEHFPRFESTP-------------------------AQTSSIPAGLA 190

  Fly   208 ASLHHSQSLRRNLGHPLAAAAAVAAVAQSQAVPNLQHTLEKSP---VAQRTA--QSSGLQANLKR 267
            |.|..:|..|:               ||.|..|......|:.|   |..|.|  :||.||.:
  Rat   191 AGLVKAQGSRK---------------AQGQVGPEGSRQEEEGPDRCVQGRRAFQKSSELQVS--- 237

  Fly   268 KRSPQDQGEVTPPPASTATSATGARS---------------RSPSPQGSIEDSSP-----GSASG 312
                .:|..:.|........|...||               |.|....:...||.     .:.:|
  Rat   238 ----AEQRGIKPYVCQLCGKAYSHRSTLQQHRRLHTGERPYRCPFCDKAYTWSSDHRKHIRTHTG 298

  Fly   313 GKP---------------------------KTFSCLECGKVFNAHYNLTR--------------- 335
            .||                           |.|.|.:||..||...:|.|
  Rat   299 EKPYGCPDCGRAFVRSSDLRKHQRNMHSNDKPFPCAQCGLTFNRPLSLLRHQRTHLGAKPFRCSC 363

  Fly   336 -------------HMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTSEKPHKCQTCGKAFNRSS 387
                         |..||:|.|||.|.:|||.|.::|.|..|:.:||.::|.||..||..|.:.|
  Rat   364 CSREFSVASRMVEHQRVHSGERPFPCSICGKCFTKSSNLHEHQTLHTGQRPFKCADCGVTFAQPS 428

  Fly   388 TLNTHSRIHAGYKPFVCEYCGKGFHQKGNYKNHKLTHSGEKAYKCNICNKAFHQVYNLTFHMHTH 452
            .|..|.|||.|.:||.|..||:.|.:....|.|:.||||:|.:.|..|.:||.....|..|:..|
  Rat   429 RLLRHQRIHTGERPFPCAECGQAFARSSTLKRHQQTHSGDKDFLCAECGRAFRIASELAQHIRMH 493

  Fly   453 NDKKPYTCRVCAKGFCRNFDLKKHMRKLHEIGGDLDDLDMPPTYDRRREYTRREPLAS 510
            |.::||.|..|.:.|.|:..|::|..| |:                    |.:||:.|
  Rat   494 NGERPYQCEGCGQTFTRSSHLQRHQAK-HD--------------------TCKEPVPS 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	68/225 (30%)
		C2H2 Zn finger	320..340	CDD:275368	8/47 (17%)
		zf-H2C2_2	332..357	CDD:290200	14/52 (27%)
		zf-C2H2	346..368	CDD:278523	9/21 (43%)
		C2H2 Zn finger	348..368	CDD:275368	8/19 (42%)
		zf-H2C2_2	363..385	CDD:290200	9/21 (43%)
		C2H2 Zn finger	376..396	CDD:275368	8/19 (42%)
		zf-H2C2_2	389..413	CDD:290200	12/23 (52%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		zf-H2C2_2	416..441	CDD:290200	11/24 (46%)
		C2H2 Zn finger	432..452	CDD:275368	6/19 (32%)
		C2H2 Zn finger	460..478	CDD:275368	6/17 (35%)
Zfp648	XP_008767911.2	C2H2 Zn finger	221..240	CDD:275368	7/25 (28%)
		C2H2 Zn finger	248..268	CDD:275368	3/19 (16%)
		zf-H2C2_2	261..284	CDD:290200	2/22 (9%)
		COG5048	272..>518	CDD:227381	74/245 (30%)
		C2H2 Zn finger	276..296	CDD:275368	3/19 (16%)
		zf-H2C2_2	290..313	CDD:290200	3/22 (14%)
		C2H2 Zn finger	304..322	CDD:275368	0/17 (0%)
		C2H2 Zn finger	333..353	CDD:275368	7/19 (37%)
		C2H2 Zn finger	361..381	CDD:275368	1/19 (5%)
		zf-H2C2_2	376..397	CDD:290200	11/20 (55%)
		zf-C2H2	387..409	CDD:278523	9/21 (43%)
		C2H2 Zn finger	389..409	CDD:275368	8/19 (42%)
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		zf-H2C2_2	430..454	CDD:290200	12/23 (52%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		zf-H2C2_2	458..480	CDD:290200	9/21 (43%)
		C2H2 Zn finger	473..493	CDD:275368	6/19 (32%)
		zf-H2C2_2	485..510	CDD:290200	9/24 (38%)
		zf-C2H2	499..521	CDD:278523	8/22 (36%)
		C2H2 Zn finger	501..521	CDD:275368	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000