DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant5 and Galnt1

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_077349.1	Gene:	Galnt1 / 79214	RGDID:	620358	Length:	559	Species:	Rattus norvegicus

Alignment Length:	605	Identity:	347/605 - (57%)
Similarity:	420/605 - (69%)	Gaps:	59/605 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CRIVLLTSLVWVIFDFVLIARYSDCIGKDGWRCKRSGEYDVELPNAERLVDDNQLVDDNEINTEK 83
            |::||.||||||:.|..|:..:|:|.     :|:...|
  Rat     7 CKVVLATSLVWVLLDMFLLLYFSECN-----KCEEKKE--------------------------- 39

  Fly    84 SLDGESGGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGKPGEMGKPVKIPADMKDLMKE 148
                         :|..:|.:              ...||:....||||||||.||.:.::.|||
  Rat    40 -------------RGLPAGDV--------------LELVQKPHEGPGEMGKPVVIPKEDQEKMKE 77

  Fly   149 KFKENQFNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINR 213
            .||.|||||:||:||:.||||.|||.|||:.|.|...|||||:|||||||||:||||||.|||||
  Rat    78 MFKINQFNLMASEMIAFNRSLPDVRLEGCKTKVYPDSLPTTSVVIVFHNEAWSTLLRTVHSVINR 142

  Fly   214 SPRALLKEIILVDDASERDFLGKQLEEYVAKLPVKTFVLRTEKRSGLIRARLLGAEHVSGEVITF 278
            |||.:::||:|||||||||||.:.||.||.||.|...|:|.|:|||||||||.||....|:||||
  Rat   143 SPRHMIEEIVLVDDASERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSKGQVITF 207

  Fly   279 LDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFEYITASDSTWGGFNWKLNFRWYRVPS 343
            ||||||||.||||||||||..:||||||||||||||:||||:..||.|:||||||||||||.||.
  Rat   208 LDAHCECTVGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQ 272

  Fly   344 REMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRVWMCGGVLEIA 408
            |||.||..|||.|:|||||||||||||:|||.|||:||.|||||||||||:|||:|.|||.|||.
  Rat   273 REMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIV 337

  Fly   409 PCSRVGHVFRKSTPYTFPGGTTEIVNHNNARLVEVWLDDWKEFYYSFYPGARKASAGDVSDRKAL 473
            .||.|||||||:|||||||||.:|:|.||.||.|||:|::|.|:|...||..|...||:|.|..|
  Rat   338 TCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRVGL 402

  Fly   474 RDRLKCKSFRWYLENVYPESLMPLDYYYLGEIRNAETETCLDTMGRKYNEKVGISYCHGLGGNQV 538
            |.:|:||.|.|||||:||:|.:|..|:.||||||.||..|||.|.||.||||||..|||:|||||
  Rat   403 RHKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQV 467

  Fly   539 FAYTKRQQIMSDDLCLDASSSNGPVNMVRCHNMGGNQEWVYDAEEKWIRHTNTGQCLQRATRDDA 603
            |:||..::|.:||||||.|..||||.|::||::.|||.|.||..:..::|.|:.|||.:||.:|:
  Rat   468 FSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDS 532

  Fly   604 NTPLLRPCSYGKGQQWLMES 623
            ..|.:|.|:..:.||||:.:
  Rat   533 QVPSIRDCTGSRSQQWLLRN 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	216/299 (72%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	63/115 (55%)
Galnt1	NP_077349.1	Catalytic subdomain A	115..225		82/109 (75%)
		pp-GalNAc-T	119..419	CDD:133004	216/299 (72%)
		Catalytic subdomain B	285..347		49/61 (80%)
		Ricin_B_lectin	432..548	CDD:395527	63/115 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	291	1.000	Domainoid score	I1480
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8469
Inparanoid	1	1.050	700	1.000	Inparanoid score	I643
OMA	1	1.010	-	-		QHG52215
OrthoDB	1	1.010	-	-		D194016at33208
OrthoFinder	1	1.000	-	-		FOG0002015
OrthoInspector	1	1.000	-	-		otm45206
orthoMCL	1	0.900	-	-		OOG6_102903
Panther	1	1.100	-	-	LDO	PTHR11675
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2292
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840