DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant5 and Galnt14

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_082140.2	Gene:	Galnt14 / 71685	MGIID:	1918935	Length:	550	Species:	Mus musculus

Alignment Length:	548	Identity:	228/548 - (41%)
Similarity:	308/548 - (56%)	Gaps:	59/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 SVVLKKWF--------LAPSVQEAKGKPGEMGKPVKIPADMKDLMKEKFKENQ------------ 154
            :|:|..|.        |.|.||..  ||.:        ||..||. |:|.|.:
Mouse    19 TVLLFFWVTKRKLEVPLGPEVQTP--KPSD--------ADWDDLW-EQFDERRYLNAKKWRVGDD 72

  Fly   155 ------FNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINR 213
                  ||...|:.||.||::.|.||:.|....|.:.||.|||:|.|||||.:|||||:.||:||
Mouse    73 PYKLYAFNQRESERISSNRAVPDTRHKRCSLLVYCTDLPPTSIIITFHNEARSTLLRTIRSVLNR 137

  Fly   214 SPRALLKEIILVDDASERDFLGKQLEEYVAKLPVKTFVLRTEKRSGLIRARLLGAEHVSGEVITF 278
            :|..|::|||||||.|......|||    .||| |...||..:|.||:|:|:.||:...|..:||
Mouse   138 TPMHLIQEIILVDDFSNDPEDCKQL----IKLP-KVKCLRNNERQGLVRSRMRGADIAQGTTLTF 197

  Fly   279 LDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFEYITASDSTWGGFNWKLNFRWYRVPS 343
            ||:|||....||:|||.|:.::...||||:||:|:.:||.||.::....|||:|.|:|:|.::..
Mouse   198 LDSHCEVNRDWLQPLLHRVKEDYTRVVCPVIDIINLDTFNYIESASELRGGFDWSLHFQWEQLSL 262

  Fly   344 REMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRVWMCGGVLEIA 408
            .:.|.| .|.|.|:|||.:|||||.|||.:|..:|.||..||||||||.|:|||||||||.|||.
Mouse   263 EQKALR-LDPTEPIRTPIIAGGLFVIDKAWFDYLGKYDVDMDIWGGENFEISFRVWMCGGGLEII 326

  Fly   409 PCSRVGHVFRKSTPYTFPGGTTEIVNHNNARLVEVWLDDWKEFYYSFYPGARKASAGDVSDRKAL 473
            |||||||||||..||.||.|.......|..|..|||:|::|::||:..|.|.:...|::.:|..|
Mouse   327 PCSRVGHVFRKKHPYVFPDGNANTYIKNTKRTAEVWMDEYKQYYYAARPFALERPFGNIENRLNL 391

  Fly   474 RDRLKCKSFRWYLENVYPESLMPLD-YYYLGEIRNAETETCLDTMGRKYNEKVGISYCHGLGG-- 535
            |..|.|::|:|||||||||..:|.| ....|.||  :.:.||::..:|..|.:.:|.|..:.|
Mouse   392 RKNLHCQTFKWYLENVYPELRVPPDSSIQKGNIR--QRQKCLESQKQKKQEILRLSPCAKVKGDG 454

  Fly   536 --NQVFAYTKRQQIMSDDLCLDASS--SNGPVNMVRCHNMGGNQEWVYDAEEKWIRHTNTGQCLQ 596
              :||:|:|..|||:.::|||...:  ...||.:..|.|....|.|......  |.|..:..||.
Mouse   455 AKSQVWAFTYTQQIIQEELCLSVVTLFPGAPVVLALCKNGDERQLWTKTGAR--IEHIASHLCLD 517

  Fly   597 R----ATRDDANTPLLRPC-SYGKGQQW 619
            .    .:.:|....::.|| |....|.|
Mouse   518 TDMFGDSTEDGKEVVVNPCESSLMSQHW 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	155/299 (52%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	35/126 (28%)
Galnt14	NP_082140.2	Catalytic subdomain A	110..215		59/109 (54%)
		Glyco_tranf_2_3	111..337	CDD:290369	127/231 (55%)
		pp-GalNAc-T	114..408	CDD:133004	155/299 (52%)
		Catalytic subdomain B	274..336		45/61 (74%)
		RICIN	422..547	CDD:238092	36/128 (28%)
		Ricin_B_lectin	422..545	CDD:279046	35/126 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750