DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant5 and GALNT16

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001161840.1	Gene:	GALNT16 / 57452	HGNCID:	23233	Length:	558	Species:	Homo sapiens

Alignment Length:	637	Identity:	233/637 - (36%)
Similarity:	324/637 - (50%)	Gaps:	117/637 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RMRSNTCRIVLLTSLVWVIFDFVLI-----ARYSDCIGKDGWRCKRSGEYDVELPNAERLVDDNQ 72
            ::|:|.  |.:|| :.|::..|..:     |..:...|:...|..|..|               |
Human     3 KIRANA--IAILT-VAWILGTFYYLWQDNRAHAASSGGRGAQRAGRRSE---------------Q 49

  Fly    73 LVDDNEINTEKSLDGESGGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGKPGEMGKPVK 137
            |.:|.                             |.|.:|             .|.|.: |...|
Human    50 LREDR-----------------------------TIPLIV-------------TGTPSK-GFDEK 71

  Fly   138 IPADMKDLM--KEKFKENQFNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTTSIVIVFHNEAW 200
            .....|.|.  ::.::::.||.|.||.:|.:|.:.|.||..|....|:|.||.||::|.|||||.
Human    72 AYLSAKQLKAGEDPYRQHAFNQLESDKLSPDRPIRDTRHYSCPSVSYSSDLPATSVIITFHNEAR 136

  Fly   201 TTLLRTVWSVINRSPRALLKEIILVDDASE--RDFLGKQLEEYVAKLPVKTFVLRTEKRSGLIRA 263
            :||||||.||:||:|..|::|||||||.|.  .|.|      .:.::| |...||.::|.||||:
Human   137 STLLRTVKSVLNRTPANLIQEIILVDDFSSDPEDCL------LLTRIP-KVKCLRNDRREGLIRS 194

  Fly   264 RLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFEYITASDSTWG 328
            |:.||:..:..|:||||:|||....||.|:|.|:.::...||.|||||||.:.|.|:.||....|
Human   195 RVRGADVAAATVLTFLDSHCEVNTEWLPPMLQRVKEDHTRVVSPIIDVISLDNFAYLAASADLRG 259

  Fly   329 GFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLE 393
            ||:|.|:|:|.::|..:...| .|.|.|:|||.:|||:|.|||.:|..:|.||..||||||||.|
Human   260 GFDWSLHFKWEQIPLEQKMTR-TDPTRPIRTPVIAGGIFVIDKSWFNHLGKYDAQMDIWGGENFE 323

  Fly   394 MSFRVWMCGGVLEIAPCSRVGHVFRKSTPYTFPGGTTEIVNHNNARLVEVWLDDWKEFYYSFYPG 458
            :|||||||||.|||.|||||||||||..||.||.|.......|..|..|||:|::|::||...|.
Human   324 LSFRVWMCGGSLEIVPCSRVGHVFRKRHPYNFPEGNALTYIRNTKRTAEVWMDEYKQYYYEARPS 388

  Fly   459 ARKASAGDVSDRKALRDRLKCKSFRWYLENVYPESLMPLDYYYLGEIRNAETETCLDTMGRKY-- 521
            |...:.|.|:.|...|.::.||||||||||||||..:|:.....|.|:  :...||::.|:..
Human   389 AIGKAFGSVATRIEQRKKMNCKSFRWYLENVYPELTVPVKEALPGIIK--QGVNCLESQGQNTAG 451

  Fly   522 NEKVGISYCHGLGGNQVFAYTKRQQIMSDDL------CLDA-----SSSNGPVNMVRCHNMGGNQ 575
            :..:|:..|.|...|...|   :..:.||.|      ||.|     ||...||.:..|:...|.|
Human   452 DFLLGMGICRGSAKNPQPA---QAWLFSDHLIQQQGKCLAATSTLMSSPGSPVILQMCNPREGKQ 513

  Fly   576 EWVYDAEEKWIRHTNTGQCLQRATRDDANTPLLRPCSY--------GKGQQW 619
            :|  ..:..:|:|:.:|.||:           .:|...        .:.|||
Human   514 KW--RRKGSFIQHSVSGLCLE-----------TKPAQLVTSKCQADAQAQQW 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	155/301 (51%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	31/136 (23%)
GALNT16	NP_001161840.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..54		6/35 (17%)
		Catalytic subdomain A	122..227		56/111 (50%)
		pp-GalNAc-T	126..420	CDD:133004	155/301 (51%)
		Catalytic subdomain B	286..348		44/61 (72%)
		Ricin_B_lectin	441..543	CDD:395527	28/117 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152448
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52215
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760