Protein Alignment Pgant5 and GALNT10

DIOPT Version :10

• Sequence 1: NP_608906.2
• Gene: Pgant5 / 326151
• FlyBaseID: FBgn0031681
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_938080.1
• Gene: GALNT10 / 55568
• HGNCID: 19873
• Length: 603
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 243/580 - (41%)
• Similarity: 327/580 - (56%)
• Gaps: 61/580 - (10%)

  Fly    82 EKSLDGESGG-----ALIMGQG---------FASGGISMTYPSVVLKKWFLAPSVQEAKGK--PG 130
            |:..||..||     |...|||         |...|..       ||.|....:::....:  .|
Human    33 ERQPDGTPGGSGAAVAPAAGQGSHSRQKKTFFLGDGQK-------LKDWHDKEAIRRDAQRVGNG 90

  Fly   131 EMGKPVKIPADMKDLMKEKFKENQFNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTTSIVIVF 195
            |.|:|  .|....:.:.:.::||.||:..||.|||||||.|:||..|..|.|...||.|||:|.|
Human    91 EQGRP--YPMTDAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPF 153

  Fly   196 HNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQLEEYVAKLPVKTFVLRTEKRSGL 260
            |||.|::|||||.||:||||..|:.||:||||.|:|:.|.|.||:|:|..| ...:|||:||.||
Human   154 HNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMALFP-SVRILRTKKREGL 217

  Fly   261 IRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFEYIT-ASD 324
            ||.|:|||...:|:||||||:|||....||.|||.||.:||:|:|||:||||..:.|.|.| |.|
Human   218 IRTRMLGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGD 282

  Fly   325 STWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGG 389
            :..|.|:|::.::...:|. |:.:.  |.:.|..:|.||||||::|:.:|:|:|.||.|::||||
Human   283 AMRGAFDWEMYYKRIPIPP-ELQKA--DPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGG 344

  Fly   390 ENLEMSFRIWQCGGILEIIPCSHVGHVFRDKSPYTFPGGVAKIVLHNAARVAEVWLDEWRDFYYS 454
            |..|:||::|.|||.:|.||||.|||::|...||..|.||:  :..|..||||||:||:.::.|.
Human   345 EQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVS--LARNLKRVAEVWMDEYAEYIYQ 407

  Fly   455 MSTGARKASAGDVSDRKALRDRLKCKSFRWYLENV-------YPESLMPLDYYYLGEIRNAETET 512
            .....|..|||||:.:|.||..|.||||:|::..:       ||....|...:  |||||..|..
Human   408 RRPEYRHLSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAW--GEIRNVGTGL 470

  Fly   513 CLDTMGRKYNEKVGISYC-HGLG-----GNQVFAYTKRQQIMSDD------LCLDASSSNGPVNM 565
            |.||........:.:..| .|.|     ..|||.:|.|:.|...|      .|.||.|...||.:
Human   471 CADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAISHTSPVTL 535

  Fly   566 VRCHNMGGNQEWVYDAEEKWIRHTNTGQCLQRATRDD---ANTPLLRPCSYGKGQQWLME 622
            ..||:|.|||.|.| .::|.:.|..:|.|:..:..|.   .||  ..|.|.  .||||.|
Human   536 YDCHSMKGNQLWKY-RKDKTLYHPVSGSCMDCSESDHRIFMNT--CNPSSL--TQQWLFE 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_608906.2	pp-GalNAc-T	190..490	CDD:133004	152/307 (50%)
		beta-trefoil_Ricin_GALNT1-like	497..623	CDD:467311	47/141 (33%)
GALNT10	NP_938080.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..59		7/20 (35%)
		Catalytic subdomain A	144..253		66/109 (61%)
		pp-GalNAc-T	148..443	CDD:133004	152/300 (51%)
		Catalytic subdomain B	311..373		35/61 (57%)
		Flexible loop	373..384		4/10 (40%)
		beta-trefoil_Ricin_GALNT10	454..603	CDD:467354	48/144 (33%)