DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant5 and GALNT9

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001116108.1	Gene:	GALNT9 / 50614	HGNCID:	4131	Length:	603	Species:	Homo sapiens

Alignment Length:	661	Identity:	230/661 - (34%)
Similarity:	327/661 - (49%)	Gaps:	100/661 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RKMRGRMRSNTCRIVLLTSLVWVIFDFVLIARYSDCIGK--------DGWRCKRSGEYDV-ELPN 63
            ||:|          .|||..:.|....||.:.|....|:        .|.|..||....| .|.:
Human     5 RKIR----------TLLTVNILVFVGIVLFSVYCRLQGRSQELVRIVSGDRRVRSRHAKVGTLGD 59

  Fly    64 AERLVDDNQLVDDNEINTEKSLDGESGG-ALIMGQ-GFASGGISMTYPSVVLKKWFLAPSVQEAK 126
            .|.::   |.:|..|......|:|.:.. .|:.|. |...||::.|          |....|||:
Human    60 REAIL---QRLDHLEEVVYNQLNGLAKPIGLVEGPGGLGQGGLAAT----------LRDDGQEAE 111

  Fly   127 GKPGEMGKPVKIPADMKDLMKEKFKENQFNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTTSI 191
            |                     |::|..:|...||.|||:||:.|.|...||:..||..||..|:
Human   112 G---------------------KYEEYGYNAQLSDRISLDRSIPDYRPRKCRQMSYAQDLPQVSV 155

  Fly   192 VIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQLEEYVAK-LPVKTFVLRTE 255
            |.:|.|||.:.:||:|.||:|.:|..||||:|||||.|:...|...|::||.| .|....::|..
Human   156 VFIFVNEALSVILRSVHSVVNHTPSQLLKEVILVDDNSDNVELKFNLDQYVNKRYPGLVKIVRNS 220

  Fly   256 KRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFE-- 318
            :|.|||||||.|.:..:..|:.|.|||.|...||.||.|:||.::||.:|.|.||.|...|||
Human   221 RREGLIRARLQGWKAATAPVVGFFDAHVEFNTGWAEPALSRIREDRRRIVLPAIDNIKYSTFEVQ 285

  Fly   319 -YITASDSTWGGFNWKLNFRW--YRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSY 380
             |..|:.    |:||.|   |  |.:|.::...| .|.:||:|||.|.|..|.:|::||.:||..
Human   286 QYANAAH----GYNWGL---WCMYIIPPQDWLDR-GDESAPIRTPAMIGCSFVVDREYFGDIGLL 342

  Fly   381 DEGMDIWGGENLEMSFRVWMCGGVLEIAPCSRVGHVFRKSTPYTFPGGTTEIVNHNNARLVEVWL 445
            |.||:::||||:|:..|||.|||.:|:.|||||.|:.|...||.  .........|..|..|||:
Human   343 DPGMEVYGGENVELGMRVWQCGGSMEVLPCSRVAHIERTRKPYN--NDIDYYAKRNALRAAEVWM 405

  Fly   446 DDWKEFYYSFY------PGARKASAGDVSDRKALRDRLKCKSFRWYLENVYPESLMPLDYYYLGE 504
            ||:|...|..:      ||   ...||||:|.|||.||||:||:|||||||||..:..:....||
Human   406 DDFKSHVYMAWNIPMSNPG---VDFGDVSERLALRQRLKCRSFKWYLENVYPEMRVYNNTLTYGE 467

  Fly   505 IRNAETET-CLDTMGRKYNEKVGISYCHGLGGNQVFAYTK----------RQQIMSDDLCLDASS 558
            :||::... ||| .|.:..::..:..|||: .:|:..|:.          ....:.|..||....
Human   468 VRNSKASAYCLD-QGAEDGDRAILYPCHGM-SSQLVRYSADGLLQLGPLGSTAFLPDSKCLVDDG 530

  Fly   559 SNGPVNMVRCHNMGGNQEWVYDAEEKW-IRHTNTGQCLQRATRDDANTPL---LRPCSYGKGQQW 619
            :.....:.:|.::....:.::|..:.. |....||:||:.....|||..|   ::.||   ||:|
Human   531 TGRMPTLKKCEDVARPTQRLWDFTQSGPIVSRATGRCLEVEMSKDANFGLRLVVQRCS---GQKW 592

  Fly   620 LMESKFKWQAH 630
            ::.:..|...|
Human   593 MIRNWIKHARH 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	140/311 (45%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	31/130 (24%)
GALNT9	NP_001116108.1	Catalytic subdomain A	150..261		52/110 (47%)
		pp-GalNAc-T	154..453	CDD:133004	140/311 (45%)
		Catalytic subdomain B	318..380		33/61 (54%)
		Ricin_B_lectin	464..592	CDD:279046	31/132 (23%)
		RICIN	466..594	CDD:238092	32/132 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152477
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740