DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant5 and GALNTL6

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_016863733.1	Gene:	GALNTL6 / 442117	HGNCID:	33844	Length:	609	Species:	Homo sapiens

Alignment Length:	552	Identity:	226/552 - (40%)
Similarity:	314/552 - (56%)	Gaps:	53/552 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 KKWFLAPSVQE---AKGKPGEMGKPVKIPADMKDLMKEKFKENQFNLLASDMISLNRSLTDVRHE 175
            |.|....|:|:   ..|| ||.|||  .|...:|.....::||.||:..|:.|:|.|||.|:||.
Human    75 KDWHDYESIQKEAMRSGK-GEHGKP--YPLTEEDHDDSAYRENGFNIFVSNNIALERSLPDIRHA 136

  Fly   176 GCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQLEE 240
            .|:.|.|..:||.|||:|.||||.||:||||:.|:|||:|.:|:.|||||||.|||:.|..:|||
Human   137 NCKHKMYLERLPNTSIIIPFHNEGWTSLLRTIHSIINRTPGSLIAEIILVDDFSEREHLKDKLEE 201

  Fly   241 YVAKLPVKTFVLRTEKRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVV 305
            |:|:.. |..::||:||.||||.|||||....|||:||||:|||....||.|||.:|..|.:|:|
Human   202 YMARFS-KVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIV 265

  Fly   306 CPIIDVISDETFEY-ITASDSTWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAGGLFSI 369
            ||:||||....|.| ..|.|:..|.|:|::.::...:|. |:.|.  |.:.|..:|.||||||::
Human   266 CPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPP-ELQRA--DPSDPFESPVMAGGLFAV 327

  Fly   370 DKDYFYEIGSYDEGMDIWGGENLEMSFRVWMCGGVLEIAPCSRVGHVFRKSTPYTFPGGTTEIVN 434
            |:.:|:|:|.||.|::|||||..|:||:||||||.:...|||||||::||..||..|.||:  :.
Human   328 DRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTS--LA 390

  Fly   435 HNNARLVEVWLDDWKEFYYSFYPGARKASAGDVSDRKALRDRLKCKSFRWYLENV-------YPE 492
            .|..|:.|.|:|::.|:.|...|..|..|.||:|.:|.||.:||||.|:|::..|       ||.
Human   391 RNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVPKYYPP 455

  Fly   493 SLMPLDYYYLGEIRNAETETCLDTMGRKYNEKVGISYCHGLGG------NQVFAYTKRQQIMSDD 551
            ...|...:  |||||.....|:|:.......::.:..|...|.      .|:|.:..|:.|...:
Human   456 VEPPPAAW--GEIRNVAANLCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGE 518

  Fly   552 ------LCLDASSSNGPVNMVRCHNMGGNQEWVYDAEEKWIRHTNTGQCLQRATRDDANTP---- 606
                  .|.||.|.|.||.:..||.|.|||.|.| .:::.:.|..:..|:      |.|..
Human   519 PLHTRKFCFDAISHNSPVTLYDCHGMKGNQLWGY-RKDRTLFHPVSNSCM------DCNPAEKKI 576

  Fly   607 -LLRPCSYGKGQQWLME-------SKFKWQAH 630
             :.|.....:.|||:.|       .||...|:
Human   577 FMARCDPLSETQQWIFEHINMTVLEKFNHHAN 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	151/307 (49%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	34/132 (26%)
GALNTL6	XP_016863733.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152504
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740