Protein Alignment Pgant5 and GALNT18

DIOPT Version :10

• Sequence 1: NP_608906.2
• Gene: Pgant5 / 326151
• FlyBaseID: FBgn0031681
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_940918.2
• Gene: GALNT18 / 374378
• HGNCID: 30488
• Length: 607
• Species: Homo sapiens
• Alignment Length: 661
• Identity: 220/661 - (33%)
• Similarity: 327/661 - (49%)
• Gaps: 116/661 - (17%)

  Fly     7 TRKMRGRMRSNTCRIVLLTSLVWVIFDFVLIARYSDCIGKDGWRCKRSGEYDVELPNAERLVDDN 71
            |||.:..:  :||  |:|:.:..:|           |:...||           :.|....|
Human     4 TRKTKTLV--STC--VILSGMTNII-----------CLLYVGW-----------VTNYIASV--- 39

  Fly    72 QLVDDNEINTEKSLDGESGGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGKPGEM-GKP 135
             .|...|...:|.|:.:.|..|.:.:       .:.:...|:|:     .:|||..||.|. .:|
Human    40 -YVRGQEPAPDKKLEEDKGDTLKIIE-------RLDHLENVIKQ-----HIQEAPAKPEEAEAEP 91

  Fly   136 V-----------KIPADMKDLMKEKFKENQFNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTT 189
            .           ::..:.:.:..::|:...:|...||.:.|:|.|.|:|..|||...:...||..
Human    92 FTDSSLFAHWGQELSPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLRPSGCRNLSFPDSLPEV 156

  Fly   190 SIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQLEEYVAKL----PVKTF 250
            |||.:|.|||.:.|||::.|.:.|:|..||||||||||.|..:.|.::|.|||.|:    |....
Human   157 SIVFIFVNEALSVLLRSIHSAMERTPPHLLKEIILVDDNSSNEELKEKLTEYVDKVNSQKPGFIK 221

  Fly   251 VLRTEKRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDE 315
            |:|..|:.||||:|:.|....:..|:...|||.|...||.||:|.||.:||:.::.|..|.|..:
Human   222 VVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFDNIKYD 286

  Fly   316 TF---EYITASDSTWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEI 377
            .|   ||..|:.    ||:|:|..|:...|.......|:  |||:|:|.:. |.|.:|:.||.||
Human   287 NFEIEEYPLAAQ----GFDWELWCRYLNPPKAWWKLENS--TAPIRSPALI-GCFIVDRQYFQEI 344

  Fly   378 GSYDEGMDIWGGENLEMSFRIWQCGGILEIIPCSHVGHVFRDKSPYTFPGGVAKIVLHNAARVAE 442
            |..||||:::||||:|:..|:|||||.:|::|||.:.|:.|...|||  ..:...|..||.||||
Human   345 GLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYT--EDLTAHVRRNALRVAE 407

  Fly   443 VWLDEWRDFYYSMSTGARKASA---GDVSDRKALRDRLKCKSFRWYLENVYPESLMPLDYYYLGE 504
            ||:||::...|......::.|.   ||::.|||||.:|:||:|||||.:||||..|..|....|.
Human   408 VWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYPEMRMYSDIIAYGV 472

  Fly   505 IRNA-ETETCLDTMGRKYNEKVGISY-CHGLGGNQVFAYTKRQQIM----------SDDLCL-DA 556
            ::|: :|:.||| .|.. .|.|.|.| |||:....|: ||..|||.          .|:.|| |.
Human   473 LQNSLKTDLCLD-QGPD-TENVPIMYICHGMTPQNVY-YTSSQQIHVGILSPTVDDDDNRCLVDV 534

  Fly   557 SS-------SNGPVNMVRCH---NMGGNQEWVYDAEEKWIRHTNTGQCLQRATRDDAN---TPLL 608
            :|       |......::.|   :.||.           |::..:.:||:.....|..   ..:|
Human   535 NSRPRLIECSYAKAKRMKLHWQFSQGGP-----------IQNRKSKRCLELQENSDLEFGFQLVL 588

  Fly   609 RPCSYGKGQQW 619
            :.||   ||.|
Human   589 QKCS---GQHW 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_608906.2	pp-GalNAc-T	190..490	CDD:133004	133/309 (43%)
		beta-trefoil_Ricin_GALNT1-like	497..623	CDD:467311	40/149 (27%)
GALNT18	NP_940918.2	Catalytic subdomain A	153..267		52/113 (46%)
		pp-GalNAc-T	157..458	CDD:133004	133/309 (43%)
		Catalytic subdomain B	324..385		31/61 (51%)
		beta-trefoil_Ricin_GALNT18	461..602	CDD:467353	41/153 (27%)