DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant5 and Galnt7

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_075215.1	Gene:	Galnt7 / 29750	RGDID:	620362	Length:	657	Species:	Rattus norvegicus

Alignment Length:	602	Identity:	225/602 - (37%)
Similarity:	327/602 - (54%)	Gaps:	47/602 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 WRCKRSGEYDVELPNAERLVDDNQLVDDNEINTEKSLDGESGGALIMGQGFASGGISMTYPSVVL 113
            |......|.|:|....:....:.|         |:...|:|...::..|.......:.||...||
  Rat    72 WPHVEGVEVDLESIRRKNKAKNEQ---------ERHAGGDSQKDIMQRQYLTFKPQTFTYRDPVL 127

  Fly   114 KKWFLA------PSVQEAKGKPGEMGKPVKIPADMKDLMKEKFKENQFNLLASDMISLNRSLTDV 172
            :...|.      |......|.|||..||:.:..:.|...:...||..||:.|||||||:||:.|:
  Rat   128 RPGVLGNFEPKEPEPHGVVGGPGENAKPLVLGPEYKQAAQASIKEFGFNMAASDMISLDRSVNDL 192

  Fly   173 RHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQ 237
            |.|.|:..||...|.|:|:|||||||.|:||:|||.|||.|:||..|.||:|:||.|.::.|.::
  Rat   193 RQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEK 257

  Fly   238 LEEYVAKL---PVKTFVLRTEKRSGLIRARLLGAEHVS-GEVITFLDAHCECTEGWLEPLLARIV 298
            |.||: ||   .||.|  |.|:|.|||:||.:||:... |:|:.:||||||....|..||:|.|.
  Rat   258 LTEYI-KLWNGLVKVF--RNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPIS 319

  Fly   299 QNRRTVVCPIIDVISDETFEYITASDSTWGGF---NWKLNFRWYRVPSREMARR-NNDRTAPLRT 359
            ::|.....||||||:..|:|.|........|:   .|..:..|.|||.....:| ...:|.|.|:
  Rat   320 KDRTICTVPIIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPREKRLRKTKTEPYRS 384

  Fly   360 PTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRVWMCGGVLEIAPCSRVGHVFR-----K 419
            |.||||||:|::|:|:|:|.||.|:.||||||.|:|:::|.|||.|...|||||||::|     .
  Rat   385 PAMAGGLFAIERDFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQG 449

  Fly   420 STPYTFPGGTTEIVNHNNARLVEVWLDDWKEFYYSFYPGARKASAGDVSDRKALRDRLKCKSFRW 484
            :.|..:.|.:..:.|:  .|:||||.|::|:::|:..|.::....||:|:.|..|:...||||:|
  Rat   450 NPPPLYVGSSPTLKNY--VRVVEVWWDEYKDYFYASRPESKALPYGDISELKKFREDHNCKSFKW 512

  Fly   485 YLENV-------YPESLMPLDYYYLGEIRNAETETCLDTMGRKYNEKVGISYCHGLGGNQVFAYT 542
            ::|.:       ||  |.|.:..: ||||..||..|:|:||:.....|.:..||.:||||:|...
  Rat   513 FMEEIAYDITAHYP--LPPRNVEW-GEIRGLETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRIN 574

  Fly   543 KRQQIMSDDLCLDASSSNGPVNMVRCHNMGGNQEWVYDAEEKWIRHTNTGQCLQRATRDDANTPL 607
            :..|:|..|.||........|.:..| |:...:||.|........|..:|:||.|:  :..:...
  Rat   575 EANQLMQYDQCLTKGPDGSKVMITHC-NLNEFKEWQYFKNLHRFTHIASGKCLDRS--EVLHQVF 636

  Fly   608 LRPCSYGK-GQQWLMES 623
            :..|..|| .|:|.|.:
  Rat   637 ISSCDNGKMTQKWEMNN 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	138/319 (43%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	38/116 (33%)
Galnt7	NP_075215.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..66
		Catalytic subdomain A	206..317		59/113 (52%)
		pp-GalNAc-T	210..518	CDD:133004	138/312 (44%)
		WcaA	210..>331	CDD:223539	62/123 (50%)
		Catalytic subdomain B	381..443		37/61 (61%)
		Ricin_B_lectin	534..649	CDD:279046	38/118 (32%)
		RICIN	535..651	CDD:238092	39/118 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345982
Domainoid	1	1.000	59	1.000	Domainoid score	I10453
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750