Protein Alignment Pgant5 and GALNT2

DIOPT Version :10

• Sequence 1: NP_608906.2
• Gene: Pgant5 / 326151
• FlyBaseID: FBgn0031681
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_004472.1
• Gene: GALNT2 / 2590
• HGNCID: 4124
• Length: 571
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 233/549 - (42%)
• Similarity: 317/549 - (57%)
• Gaps: 32/549 - (5%)

  Fly    90 GGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGK------PGEMGKP-----VKIPADMK 143
            |.||..|.|..:|..........:||..|..|..|.|.:      ||::..|     ..:...|.
Human    28 GSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMV 92

  Fly   144 DLMKEKFKENQFNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVW 208
            ...::.:..|:||.:.||.:.::|::.|.||:.|:||.:...||.||:||.|||||.:.|||||.
Human    93 RSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVV 157

  Fly   209 SVINRSPRALLKEIILVDDAS----ERDFLGKQLEEYVAKLPVKTFVLRTEKRSGLIRARLLGAE 269
            ||:.:||..|:||||||||.|    :...||| :|        |..|||.::|.||:|:|:.||:
Human   158 SVLKKSPPHLIKEIILVDDYSNDPEDGALLGK-IE--------KVRVLRNDRREGLMRSRVRGAD 213

  Fly   270 HVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFEYITASDSTWGGFNWKL 334
            ....:|:||||:||||.|.||||||.|:.::|..||.||||||:.:.|:|:.||....|||:|.|
Human   214 AAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNL 278

  Fly   335 NFRW-YRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRI 398
            .|:| |..|.:..:|:.|. .||::||.:|||||.:||.||.|:|.||..||:|||||||:|||:
Human   279 VFKWDYMTPEQRRSRQGNP-VAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRV 342

  Fly   399 WQCGGILEIIPCSHVGHVFRDKSPYTFPGGVAKIVLHNAARVAEVWLDEWRDFYYSMSTGARKAS 463
            |||||.|||||||.||||||.:.|||||||...:...|..|.||||:||:::|||:....||...
Human   343 WQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVP 407

  Fly   464 AGDVSDRKALRDRLKCKSFRWYLENVYPESLMPLDYYYLGEIRNAETETCLDTMGRKYNEKVGIS 528
            .|::..|..||.:|.||.|:|||||||||..:| |:..:......:...||||:|...:..||:.
Human   408 YGNIQSRLELRKKLSCKPFKWYLENVYPELRVP-DHQDIAFGALQQGTNCLDTLGHFADGVVGVY 471

  Fly   529 YCHGLGGNQVFAYTKRQQIMSDDLCLDASSSNGPVNMVR---CHNMGGNQEWVYDAEEKWIRHTN 590
            .||..||||.:|.||.:.:...||||.. ....|.::::   |......|:|........:||..
Human   472 ECHNAGGNQEWALTKEKSVKHMDLCLTV-VDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVG 535

  Fly   591 TGQCLQRATRDDANTPLLRPCSYGKGQQW 619
            :..||...|....... :..|.....|||
Human   536 SNLCLDSRTAKSGGLS-VEVCGPALSQQW 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_608906.2	pp-GalNAc-T	190..490	CDD:133004	163/304 (54%)
		beta-trefoil_Ricin_GALNT1-like	497..623	CDD:467311	34/126 (27%)
GALNT2	NP_004472.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..74		5/20 (25%)
		Catalytic subdomain A	135..240		61/113 (54%)
		pp-GalNAc-T	139..434	CDD:133004	163/304 (54%)
		Catalytic subdomain B	300..362		44/61 (72%)
		beta-trefoil_Ricin_GALNT2	446..565	CDD:467312	33/120 (28%)