DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant5 and Galnt6

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001155239.1	Gene:	Galnt6 / 207839	MGIID:	1891640	Length:	622	Species:	Mus musculus

Alignment Length:	665	Identity:	269/665 - (40%)
Similarity:	358/665 - (53%)	Gaps:	106/665 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RMRSNTCRIVLLTSLVWVIFDFVLIARYSDCIGKDGWRCKRSGEYDVELPNAERLVDDNQLVDDN 77
            |.|..:.|:.:|.| |:::|.|:   |..|                  :.|.|:.::...|
Mouse     5 RRRHMSLRLAMLGS-VFMLFLFI---RQKD------------------VSNQEQAMEKPWL---- 43

  Fly    78 EINTEKSLDGESGGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGK-----------PGE 131
                 |||.|:....|    .|..|.:: ....|:.|....||...:....           |.|
Mouse    44 -----KSLAGQKDQVL----DFMLGAVN-NIRDVMPKLQIRAPEPPQTLVSTNHSCLPGFYTPAE 98

  Fly   132 M----GKPVKIP----ADMKDLMK------------EKFKENQFNLLASDMISLNRSL-TDVRHE 175
            :    .:|.:.|    ||.|...|            |.:|::.||..|||.|||.||| .|.|..
Mouse    99 LKPFWDRPPQDPNSPGADGKAFQKKEWTNLETKEKEEGYKKHCFNAFASDRISLQRSLGPDTRPP 163

  Fly   176 GC--RRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQL 238
            .|  ::......|||||::||||||||:||||||:||::.||..||||||||||||..:.|.::|
Mouse   164 ECVDQKFRRCPPLPTTSVIIVFHNEAWSTLLRTVYSVLHTSPAILLKEIILVDDASTDEHLKERL 228

  Fly   239 EEYVAKLPVKTFVLRTEKRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRT 303
            |:||.:|.: ..|:|..:|.|||.||||||.....||:|||||||||..||||||||||.:::..
Mouse   229 EQYVQQLQI-VRVVRQRERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTA 292

  Fly   304 VVCPIIDVISDETFEYI----TASDSTWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAG 364
            ||.|.|..|...||::.    .....:.|.|:|.|.|.|..:|..|..|| .|.|.|:::||.||
Mouse   293 VVSPDIVTIDLNTFQFSRPVQRGKAHSRGNFDWSLTFGWEMLPEHEKQRR-KDETYPIKSPTFAG 356

  Fly   365 GLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRVWMCGGVLEIAPCSRVGHVFRKSTPYTFPGGT 429
            |||||.|.||..||:||..|:||||||:|||||||.|||.|||.|||.||||||..:|:|||.||
Mouse   357 GLFSISKAYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGT 421

  Fly   430 TEIVNHNNARLVEVWLDDWKEFYYSFYPGARKA----SAGDVSDRKALRDRLKCKSFRWYLENVY 490
            : ::..|..||.|||:||:|:.:|.....|.|.    :.||:|:|..||::|:|.:|.|||.|||
Mouse   422 S-VIARNQVRLAEVWMDDYKKIFYRRNLQAAKMVQENNFGDISERLRLREQLRCHNFSWYLHNVY 485

  Fly   491 PESLMP-LDYYYLGEIRNAETETCLDTMGRKYNEKVGISY-CHGLGGNQVFAYTKRQQI---MSD 550
            ||..:| |:..:.|.|:|..|..|||........|..|.| ||.|||||.|.||.::.:   :..
Mouse   486 PEMFVPDLNPTFYGAIKNLGTNQCLDVGENNRGGKPLIMYVCHNLGGNQYFEYTSQRDLRHNIGK 550

  Fly   551 DLCLDASSSNGPVNMVRCHNMGGN------QEWVYDAEEKWIRHTNTGQCLQRATRDDANTPLLR 609
            .|||.||.|.  :.:..|..:|.|      :||.. .:::.||::.:|.||   |..| ..|.:.
Mouse   551 QLCLHASGST--LGLRSCQFVGKNSRVPKDEEWEL-TQDQLIRNSGSGTCL---TSQD-KKPAMA 608

  Fly   610 PCS----YGKGQQWL 620
            ||:    |   |.||
Mouse   609 PCNPRDPY---QLWL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	166/307 (54%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	43/129 (33%)
Galnt6	NP_001155239.1	Catalytic subdomain A	176..285		71/109 (65%)
		pp-GalNAc-T	180..485	CDD:133004	166/307 (54%)
		Catalytic subdomain B	348..410		44/61 (72%)
		Ricin_B_lectin	497..619	CDD:366226	43/131 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850