Protein Alignment Pgant5 and Galnt4

DIOPT Version :10

• Sequence 1: NP_608906.2
• Gene: Pgant5 / 326151
• FlyBaseID: FBgn0031681
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_056552.1
• Gene: Galnt4 / 14426
• MGIID: 894692
• Length: 578
• Species: Mus musculus
• Alignment Length: 638
• Identity: 255/638 - (39%)
• Similarity: 352/638 - (55%)
• Gaps: 88/638 - (13%)

  Fly    10 MRGRMRSNTCRIVLLTSLVWVIFDFVLIARYSDCIGKDGWRCKRSGEYDVELPNAERLVDDNQLV 74
            :|......:|.::.|.:|.:::.:|.:...|:. .|..|.|         || ...||.|    :
Mouse     3 VRWTWAGKSCLLLALLTLAYILVEFSVSTLYAS-PGAGGAR---------EL-GPRRLPD----L 52

  Fly    75 DDNEINTEKSLDGESGGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGKPGEMGKPVKIP 139
            |..|.:..:.|                              :...|:...|.   ||.|:..|:.
Mouse    53 DTREEDLSQPL------------------------------YIKPPADSHAL---GEWGRASKLQ 84

  Fly   140 ADMKDL--MKEKFKENQFNLLASDMISLNRSLTDVRHEGCRRK--HYASKLPTTSIVIVFHNEAW 200
            .:..:|  .:|..:....|:..||.|||:|.:.|.|...|:.|  ||.| |||||::|.|:||||
Mouse    85 LNEGELKQQEELIERYAINIYLSDRISLHRHIEDKRMYECKAKKFHYRS-LPTTSVIIAFYNEAW 148

  Fly   201 TTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQLEEYVAKLPVKTFVLRTEKRSGLIRARL 265
            :|||||:.||:..||..||||||||||.|:|.:|..|||.|::.|. :..::||.||.||:||||
Mouse   149 STLLRTIHSVLETSPAVLLKEIILVDDLSDRIYLKAQLETYISNLE-RVRLIRTNKREGLVRARL 212

  Fly   266 LGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFE-YITASDSTWGG 329
            :||...:|:|:||||.||||..|||||||.||.::...:|||:||.|...||| |:...:...||
Mouse   213 IGATFATGDVLTFLDCHCECNTGWLEPLLERISRDETAIVCPVIDTIDWNTFEFYMQTGEPMIGG 277

  Fly   330 FNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEM 394
            |:|:|.|:|:.||..|..||.: |..|:|:||||||||::.|.||..:|:||.||::|||||||:
Mouse   278 FDWRLTFQWHSVPKHERDRRTS-RIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLEL 341

  Fly   395 SFRIWQCGGILEIIPCSHVGHVFRDKSPYTFPGGVAKIVLHNAARVAEVWLDEWRDFYYSMSTGA 459
            |||:|||||.|||.|||||||||..::||..|.     .|.|.||.||||:||:::.:|:.:..|
Mouse   342 SFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPN-----FLQNTARAAEVWMDEYKEHFYNRNPPA 401

  Fly   460 RKASAGDVSDRKALRDRLKCKSFRWYLENVYPESLMPLDY-YYLGEIRN-AETETCLDTMGRKYN 522
            ||.:.||:|:||.||:|||||||.|||:||:....:|.|. .:.|.||: ..:..|||     ||
Mouse   402 RKEAYGDLSERKLLRERLKCKSFDWYLKNVFSNLHVPEDRPGWHGAIRSMGISSECLD-----YN 461

  Fly   523 --------EKVGISYCHGLGGNQVFAYTKRQQIMSD---DLCLDASSSNGPVNMVRCHNMG---- 572
                    ..:.:..|||.||||.|.||..::|..:   :||.:.......|.|..|...|
Mouse   462 APDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPQQKDYVGMQNCPKDGLPVP 526

  Fly   573 GNQEWVYDAEEKWIRHTNTGQCLQRATRDDANTPL--LRPC-SYGKGQQWLME 622
            .|..|.: .|:..|.|.:|..||. |.|.....|.  ::.| :..|.|.|..|
Mouse   527 VNIIWHF-KEDGTIFHPHTRLCLS-AYRTAEGRPSVHMKTCDALDKNQLWRFE 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_608906.2	pp-GalNAc-T	190..490	CDD:133004	168/300 (56%)
		beta-trefoil_Ricin_GALNT1-like	497..623	CDD:467311	42/146 (29%)
Galnt4	NP_056552.1	Catalytic subdomain A	134..243		67/109 (61%)
		pp-GalNAc-T	138..432	CDD:133004	168/300 (56%)
		Catalytic subdomain B	303..365		44/61 (72%)
		beta-trefoil_Ricin-like	442..577	CDD:483949	40/141 (28%)