DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant5 and Galnt3

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_056551.2	Gene:	Galnt3 / 14425	MGIID:	894695	Length:	633	Species:	Mus musculus

Alignment Length:	638	Identity:	263/638 - (41%)
Similarity:	353/638 - (55%)	Gaps:	82/638 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VIFDFVLI---------ARYSDCIGKDGWRCKRSGEYDVELPNAERLVD-----DNQLVD---DN 77
            |||.|:::         .:||          |...:.:..|.|..:::|     .|.:.|   ..
Mouse    26 VIFFFLVVLILMQREVSVQYS----------KEESKMERNLKNKNKMLDFMLEAVNNIKDAMPKM 80

  Fly    78 EINT--EKSLDGESGGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGKPGEMGKPVKI-- 138
            :|..  ::::|......|   ||:        |.:..||..|..|  .:....||..|||.||
Mouse    81 QIGAPIKENIDVRERPCL---QGY--------YTAAELKPVFDRP--PQDSNAPGASGKPFKITH 132

  Fly   139 --PADMKDLMKEKFK-ENQFNLLASDMISLNRSL-TDVRHEGCRRKHY--ASKLPTTSIVIVFHN 197
              |.:.|:  ||:.: ::.||..|||.|||:|.| .|.|...|..:.:  ...|||||::|||||
Mouse   133 LSPEEQKE--KERGETKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHN 195

  Fly   198 EAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQLEEYVAKLPVKTFVLRTEKRSGLIR 262
            |||:||||||.||:..||..||||||||||||..|:|.::||||:.:..: ..::|.::|.|||.
Mouse   196 EAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDDYLHEKLEEYIKQFSI-VKIVRQQERKGLIT 259

  Fly   263 ARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFEYIT----AS 323
            ||||||...:.|.:|||||||||..||||||||||.:|...||.|.|..|...|||:..    .|
Mouse   260 ARLLGAAVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGS 324

  Fly   324 DSTWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWG 388
            :...|.|:|.|:|.|..:|..|..|| .|.|.|::|||.|||||||.|.||..||||||.|:|||
Mouse   325 NHNRGNFDWSLSFGWESLPDHEKQRR-KDETYPIKTPTFAGGLFSISKKYFEHIGSYDEEMEIWG 388

  Fly   389 GENLEMSFRVWMCGGVLEIAPCSRVGHVFRKSTPYTFPGGTTEIVNHNNARLVEVWLDDWKEFYY 453
            |||:|||||||.|||.|||.|||.||||||..:|:|||.| |:::..|..||.|||:|::||.:|
Mouse   389 GENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHTFPKG-TQVIARNQVRLAEVWMDEYKEIFY 452

  Fly   454 SFYPGARK----ASAGDVSDRKALRDRLKCKSFRWYLENVYPESLMP-LDYYYLGEIRNAETETC 513
            .....|.|    .|.||:|.|..::.||:||:|.|||..:|||:.:| |:....|.|::.....|
Mouse   453 RRNTDAAKIVKQKSFGDLSKRFEIKKRLQCKNFTWYLNTIYPEAYVPDLNPVISGYIKSVGQPLC 517

  Fly   514 LDTMGRKYNEKVGISY-CHGLGGNQVFAYTKRQQI---MSDDLCLDASSSNGPVNMVRCHNMG-- 572
            ||........|..|.| ||||||||.|.|:.:::|   :..:|||.|  :.|.|.:..|...|
Mouse   518 LDVGENNQGGKPLILYTCHGLGGNQYFEYSAQREIRHNIQKELCLHA--TQGVVQLKACVYKGHR 580

  Fly   573 ----GNQEWVYDAEEKWIRHTNTGQCLQRATRDDANTPLLRPC-SYGKGQQWL 620
                |.|.|.. .:::.:.:.....||.    .:...|.|.|| :....|:|:
Mouse   581 TIAPGEQIWEI-RKDQLLYNPLFKMCLS----SNGEHPNLVPCDATDLLQKWI 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	170/307 (55%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	37/126 (29%)
Galnt3	NP_056551.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..145		12/36 (33%)
		WcaA	184..>302	CDD:223539	73/118 (62%)
		Catalytic subdomain A	184..293		69/109 (63%)
		pp-GalNAc-T	188..493	CDD:133004	170/307 (55%)
		Catalytic subdomain B	356..418		47/61 (77%)
		Ricin_B_lectin	506..627	CDD:279046	37/127 (29%)
		RICIN	507..629	CDD:238092	38/129 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850