Protein Alignment Pgant5 and Galnt1

DIOPT Version :10

• Sequence 1: NP_608906.2
• Gene: Pgant5 / 326151
• FlyBaseID: FBgn0031681
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_038842.3
• Gene: Galnt1 / 14423
• MGIID: 894693
• Length: 559
• Species: Mus musculus
• Alignment Length: 605
• Identity: 346/605 - (57%)
• Similarity: 422/605 - (69%)
• Gaps: 59/605 - (9%)

  Fly    19 CRIVLLTSLVWVIFDFVLIARYSDCIGKDGWRCKRSGEYDVELPNAERLVDDNQLVDDNEINTEK 83
            |::||.||||||:.|..|:..:|:|.     :|:...|
Mouse     7 CKVVLATSLVWVLLDMFLLLYFSECN-----KCEEKQE--------------------------- 39

  Fly    84 SLDGESGGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGKPGEMGKPVKIPADMKDLMKE 148
                         :|..:|.:              ...||:....||||||||.||.:.::.|||
Mouse    40 -------------RGLPAGDV--------------LELVQKPHEGPGEMGKPVVIPKEDQEKMKE 77

  Fly   149 KFKENQFNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINR 213
            .||.|||||:||:||:|||||.|||.|||:.|.|...|||||:|||||||||:||||||.|||||
Mouse    78 MFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINR 142

  Fly   214 SPRALLKEIILVDDASERDFLGKQLEEYVAKLPVKTFVLRTEKRSGLIRARLLGAEHVSGEVITF 278
            |||.:::||:|||||||||||.:.||.||.||.|...|:|.|:|||||||||.||....|:||||
Mouse   143 SPRHMIEEIVLVDDASERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSRGQVITF 207

  Fly   279 LDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFEYITASDSTWGGFNWKLNFRWYRVPS 343
            ||||||||.||||||||||..:||||||||||||||:||||:..||.|:||||||||||||.||.
Mouse   208 LDAHCECTAGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQ 272

  Fly   344 REMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRIWQCGGILEII 408
            |||.||..|||.|:|||||||||||||:|||.|||:||.|||||||||||:|||||||||.|||:
Mouse   273 REMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIV 337

  Fly   409 PCSHVGHVFRDKSPYTFPGGVAKIVLHNAARVAEVWLDEWRDFYYSMSTGARKASAGDVSDRKAL 473
            .|||||||||..:|||||||..:|:..|..|:||||:||:::|:|.:|.|..|...||:|.|..|
Mouse   338 TCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRLGL 402

  Fly   474 RDRLKCKSFRWYLENVYPESLMPLDYYYLGEIRNAETETCLDTMGRKYNEKVGISYCHGLGGNQV 538
            |.:|:||.|.|||||:||:|.:|..|:.||||||.||..|||.|.||.||||||..|||:|||||
Mouse   403 RRKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQV 467

  Fly   539 FAYTKRQQIMSDDLCLDASSSNGPVNMVRCHNMGGNQEWVYDAEEKWIRHTNTGQCLQRATRDDA 603
            |:||..::|.:||||||.|..||||.|::||::.|||.|.||..:..::|.|:.|||.:||.:|:
Mouse   468 FSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDS 532

  Fly   604 NTPLLRPCSYGKGQQWLMES 623
            ..|.:|.|:..:.||||:.:
Mouse   533 QVPSIRDCTGSRSQQWLLRN 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_608906.2	pp-GalNAc-T	190..490	CDD:133004	214/299 (72%)
		beta-trefoil_Ricin_GALNT1-like	497..623	CDD:467311	68/125 (54%)
Galnt1	NP_038842.3	Catalytic subdomain A. /evidence=ECO:0000305|PubMed:10037781	115..225		82/109 (75%)
		pp-GalNAc-T	119..419	CDD:133004	214/299 (72%)
		Catalytic subdomain B. /evidence=ECO:0000305|PubMed:10037781	285..347		52/61 (85%)
		beta-trefoil_Ricin_GALNT1	426..552	CDD:467344	68/125 (54%)