Protein Alignment Pgant5 and GALNT15

DIOPT Version :10

• Sequence 1: NP_608906.2
• Gene: Pgant5 / 326151
• FlyBaseID: FBgn0031681
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_473451.3
• Gene: GALNT15 / 117248
• HGNCID: 21531
• Length: 639
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 196/535 - (36%)
• Similarity: 289/535 - (54%)
• Gaps: 53/535 - (9%)

  Fly   124 EAKGKPGEMGKPVKIP-------------ADMKDLMKEKFKENQFNL-------LASDMISLNRS 168
            :::|:.|...:.:|.|             ||....:.|:.:...|:|       ..|..|.|.|:
Human   108 QSQGRRGGSYRLIKQPRRQDKEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRA 172

  Fly   169 LTDVRHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDF 233
            |.:|||..|.::|....|||.|:::.||:|||:||||||.|:::..|||.|||||||||.|::..
Human   173 LPEVRHPLCLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQ 237

  Fly   234 LGKQLEEYVAKLP-VKTFVLRTEKRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARI 297
            |...|.||||:|. ||  :||:.||.|.||||:|||...:|:|:.|:||||||..|||||||:||
Human   238 LKSALSEYVARLEGVK--LLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRI 300

  Fly   298 VQNRRTVVCPIIDVISDETFEYITASDSTWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTM 362
            ..:|..||.|:||||..:||:|..:.|...|..:|||:|.|..:| ..:.:......:|:|:|.:
Human   301 AGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLP-EHVRKALQSPISPIRSPVV 364

  Fly   363 AGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRIWQCGGILEIIPCSHVGHVFRDK---SPYT 424
            .|.:.::|:.||...|:||..|.:.||||||:||:.|.|||.:||:|||.|||:::::   ||..
Human   365 PGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQNQDSHSPLD 429

  Fly   425 FPGGVAKIVLHNAARVAEVWLDEWRDFYYSMSTGA---RKASAGDVSDRKALRDRLKCKSFRWYL 486
                 .:..|.|..|:||.||..:::.:|..|..|   .||...|..:|..|:.||.|::|.|:|
Human   430 -----QEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRLGCRTFHWFL 489

  Fly   487 ENVYPESLMPLD--YYYLGEIRNAETETCLDTMGRKYNEKVG----ISYCHGLGGNQVFAYTKRQ 545
            .||||| |.|.:  ..:.|::.|.....|.|....  .:.:|    ::.|......|...:|.|:
Human   490 ANVYPE-LYPSEPRPSFSGKLHNTGLGLCADCQAE--GDILGCPMVLAPCSDSRQQQYLQHTSRK 551

  Fly   546 QI---MSDDLCLDASSSNGPVNMVRCHNMG---GNQEWVYDAEEKWIRHTNTGQCLQRATRDDAN 604
            :|   ....||.......  |.:..|...|   ..|.|.:. |...|.|..:|:|::...:::..
Human   552 EIHFGSPQHLCFAVRQEQ--VILQNCTEEGLAIHQQHWDFQ-ENGMIVHILSGKCMEAVVQENNK 613

  Fly   605 TPLLRPCSYGKGQQW 619
            ...||||.....|||
Human   614 DLYLRPCDGKARQQW 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_608906.2	pp-GalNAc-T	190..490	CDD:133004	139/306 (45%)
		beta-trefoil_Ricin_GALNT1-like	497..623	CDD:467311	29/135 (21%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..155		8/46 (17%)
		Catalytic subdomain A	190..299		66/110 (60%)
		pp-GalNAc-T	194..493	CDD:133004	139/306 (45%)
		Catalytic subdomain B	358..420		31/61 (51%)
		beta-trefoil_Ricin_GALNT15	502..629	CDD:467320	29/132 (22%)