DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant5 and GALNT5

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_016858726.1	Gene:	GALNT5 / 11227	HGNCID:	4127	Length:	956	Species:	Homo sapiens

Alignment Length:	464	Identity:	199/464 - (42%)
Similarity:	292/464 - (62%)	Gaps:	11/464 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LAPSVQEAKGKPGEMGKPVKIPADMKDLMKEKFKENQFNLLASDMISLNRSLTDVRHEGCRRKHY 182
            |:|...:|   ||:.|:||.:|...:...:.::||..||:..||:|.::|::.|.|..||..:..
Human   430 LSPRDPKA---PGQFGRPVVVPHGKEKEAERRWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLV 491

  Fly   183 ASKLPTTSIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQLEEYVAKLPV 247
            .:.|||||:::.|.:|.|:||||:|.|||||||..|:|||:||||.|.:|:|...|::|:::.|
Human   492 HNNLPTTSVIMCFVDEVWSTLLRSVHSVINRSPPHLIKEILLVDDFSTKDYLKDNLDKYMSQFP- 555

  Fly   248 KTFVLRTEKRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVI 312
            |..:||.::|.|||||||.||::.:|:|:||||:|.||..|||||||.|:..:|:.|.||:|:||
Human   556 KVRILRLKERHGLIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVI 620

  Fly   313 SDETFEYITASDSTWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEI 377
            :|:...|:|..:...|.|.|.:||.|..:|...:|:.....|..:|.|.||||||||||.||:|:
Human   621 NDKDMSYMTVDNFQRGIFVWPMNFGWRTIPPDVIAKNRIKETDTIRCPVMAGGLFSIDKSYFFEL 685

  Fly   378 GSYDEGMDIWGGENLEMSFRVWMCGGVLEIAPCSRVGHVFRKSTPYTFPGGTTEIVNHNNARLVE 442
            |:||.|:|:|||||:|:||:||||||.:||.|||||||:||...||:||....:.|..|..|:.|
Human   686 GTYDPGLDVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAE 750

  Fly   443 VWLDDWKEFYYSF--YPGARKASAGDVSDRKALRDRLKCKSFRWYLENVYPESLMPLDYYYLGEI 505
            ||||::||.:|..  :...:....|:::.::.||.:||||||:||||||:|:...|: ....|.:
Human   751 VWLDEYKELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCKSFKWYLENVFPDLRAPI-VRASGVL 814

  Fly   506 RNAETETCLDTMGRKYNEKVGISYCHGLGGNQVFAYTKRQQIMSDDLCLDASSSNGPVNMVRCHN 570
            .|.....|:..    .|..|.:..|.|....|.|.||..:.|...:.|:......|.|.:..|.|
Human   815 INVALGKCISI----ENTTVILEDCDGSKELQQFNYTWLRLIKCGEWCIAPIPDKGAVRLHPCDN 875

  Fly   571 MGGNQEWVY 579
            .....:|::
Human   876 RNKGLKWLH 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	153/301 (51%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	18/77 (23%)
GALNT5	XP_016858726.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152496
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194016at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750