DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant5 and Galnt16

DIOPT Version :9

Sequence 1:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001074890.1	Gene:	Galnt16 / 108760	MGIID:	1917754	Length:	558	Species:	Mus musculus

Alignment Length:	538	Identity:	218/538 - (40%)
Similarity:	301/538 - (55%)	Gaps:	67/538 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 QEAKGKPGEMGKPVKIPA----------DMKDLMKEK--------FKENQFNLLASDMISLNRSL 169
            |.|.|:|.::.:...||.          |.|..:..|        ::::.||.|.||.:|.:|.:
Mouse    41 QRAGGRPEQLREDRTIPLIVTGTPSKGFDEKAYLSAKQLKPGEDPYRQHAFNQLESDKLSSDRPI 105

  Fly   170 TDVRHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASE--RD 232
            .|.||..|....|:|.||.||::|.|||||.:||||||.||:||:|.:|::|||||||.|.  .|
Mouse   106 RDTRHYSCPSLSYSSDLPATSVIITFHNEARSTLLRTVKSVLNRTPASLIQEIILVDDFSSDPED 170

  Fly   233 FLGKQLEEYVAKLPVKTFVLRTEKRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARI 297
            .|      .:.::| |...||.:||.||||:|:.||:.....|:||||:|||....||:|:|.|:
Mouse   171 CL------LLTRIP-KVKCLRNDKREGLIRSRVRGADVAGATVLTFLDSHCEVNVEWLQPMLQRV 228

  Fly   298 VQNRRTVVCPIIDVISDETFEYITASDSTWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTM 362
            :::...||.|||||||.:.|.|:.||....|||:|.|:|:|.::|..:...| .|.|.|:|||.:
Mouse   229 MEDHTRVVSPIIDVISLDNFAYLAASADLRGGFDWSLHFKWEQIPLEQKMTR-TDPTKPIRTPVI 292

  Fly   363 AGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRVWMCGGVLEIAPCSRVGHVFRKSTPYTFPG 427
            |||:|.|||.:|..:|.||..||||||||.|:|||||||||.|||.|||||||||||..||.||.
Mouse   293 AGGIFVIDKSWFNHLGKYDAQMDIWGGENFELSFRVWMCGGSLEIVPCSRVGHVFRKRHPYNFPE 357

  Fly   428 GTTEIVNHNNARLVEVWLDDWKEFYYSFYPGARKASAGDVSDRKALRDRLKCKSFRWYLENVYPE 492
            |.......|..|..|||:|::|::||...|.|...:.|.|:.|...|.::.||||||||||||||
Mouse   358 GNALTYIRNTKRTAEVWMDEYKQYYYEARPSAIGKAFGSVATRIEQRKKMDCKSFRWYLENVYPE 422

  Fly   493 SLMPLDYYYLGEIRNAETETCLDTMGRKY--NEKVGISYCHGLGGNQVFAYTKRQQIMSDDL--- 552
            ..:|:.....|.|:  :...||::.|:..  :..:|:..|.|...:...|   :..:.||.|
Mouse   423 LTVPVKEVLPGVIK--QGVNCLESQGQNTAGDLLLGMGICRGSAKSPPPA---QAWLFSDHLIQQ 482

  Fly   553 ---CLDA-----SSSNGPVNMVRCHNMGGNQEWVYDAEEKWIRHTNTGQCLQRATRDDANTPLLR 609
               ||.|     ||...||.:..|:...|.|:|  ..:..:|:|:.:|.||:           .:
Mouse   483 QGKCLAATSTLMSSPGSPVILQTCNPKEGKQKW--RRKGSFIQHSVSGLCLE-----------TK 534

  Fly   610 PCSY--------GKGQQW 619
            |...        .:.|||
Mouse   535 PAQLVTSKCQTDAQAQQW 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	156/301 (52%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	30/136 (22%)
Galnt16	NP_001074890.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..53		4/11 (36%)
		Catalytic subdomain A	122..227		57/111 (51%)
		pp-GalNAc-T	126..420	CDD:133004	156/301 (52%)
		Catalytic subdomain B	286..348		44/61 (72%)
		Ricin_B_lectin	441..552	CDD:306998	28/126 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52215
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.760