DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31650 and rcn2

DIOPT Version :9

Sequence 1:	NP_001162879.1	Gene:	CG31650 / 326150	FlyBaseID:	FBgn0031673	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_001116488.1	Gene:	rcn2 / 733807	XenbaseID:	XB-GENE-5917368	Length:	313	Species:	Xenopus tropicalis

Alignment Length:	326	Identity:	122/326 - (37%)
Similarity:	177/326 - (54%)	Gaps:	39/326 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 AVANSHKHEKHLSKERVKDGIYAPRDAHHHGEDGEHNVEFDHEAIIGNTKEAQEFDSLSPDESKR 93
            |.:.:|:||:|.                   |:||||.|||.:..:|..:||:||..|||::..:
Frog    15 AFSLAHQHEEHY-------------------ENGEHNAEFDKKMFLGGEEEAEEFTELSPEDQLK 60

  Fly    94 RLLILIKMMDLNKDEFIDRHELKAWILRSFKKLSEEEAADRFEEIDQDADERITWKEYLQDTYAM 158
            ||..:|:.:|.:.|.::...||..||.:|||....|:..:.|.|||:|.|..:||.||....|
Frog    61 RLKSIIRKIDTDSDGYLTEEELSFWIQKSFKHYILEDTKEHFAEIDKDGDGIVTWDEYNMHMY-- 123

  Fly   159 EDEDFKKETIDYDS----YEDEQKMIKQ----DKEMFNAADTNKDGVLTLEEFVLFQNPEEHPQM 215
                  ...||||.    .::|::..:|    ||..|:.||.:....|.|.||..|::|||...|
Frog   124 ------DRIIDYDENTVLEDEEEESFRQIHLRDKRRFDHADRDDIPGLNLTEFTDFEHPEETDHM 182

  Fly   216 LPILLEHTMQDKDADHDGKINFQEFVG----DAASHHDKEWLITEKERFDKDHDSNGDGVLTGDE 276
            ...::|..:::.|.|.||.::.:|::|    |..:..|..|||.||:||..|:|.:|||.|...|
Frog   183 SEFVIEGALEEHDKDGDGFVSLEEYLGDYTQDPGTVEDPHWLIVEKDRFMNDYDKDGDGRLNPVE 247

  Fly   277 VLSWIVPSNTAIANDEVDHLFVSTDEDHDDRLSYLEILNNYDTFVGSEATDYGDHLQNINHLSDE 341
            :||||||:|..|:.:|..||....|::.|.|||..|||.|.|.|:.|||||||..||:.:...||
Frog   248 LLSWIVPNNLGISQEEASHLMEEMDKNEDQRLSEEEILQNKDIFLTSEATDYGRQLQDKHFYHDE 312

  Fly   342 L 342
            |
Frog   313 L 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31650	NP_001162879.1	EF-hand_7	100..153	CDD:290234	20/52 (38%)
		EFh	100..153	CDD:298682	20/52 (38%)
		EF-hand_7	184..241	CDD:290234	19/56 (34%)
		EFh	184..241	CDD:298682	19/56 (34%)
		EFh	228..281	CDD:298682	24/56 (43%)
rcn2	NP_001116488.1	EFh_CREC_RCN2	25..292	CDD:320022	105/293 (36%)
		EF-hand motif	25..55	CDD:320022	15/48 (31%)
		EF-hand motif	61..90	CDD:320022	9/28 (32%)
		EF-hand motif	97..126	CDD:320022	11/36 (31%)
		EF-hand motif	149..178	CDD:320022	11/28 (39%)
		EF-hand motif	186..215	CDD:320022	7/28 (25%)
		EF-hand motif	227..256	CDD:320022	17/28 (61%)
		EF-hand motif	263..292	CDD:320022	13/28 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I6929
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2176
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3487
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	1	1.000	-	-		oto102371
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060