DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31650 and RCN3

DIOPT Version :9

Sequence 1:	NP_001162879.1	Gene:	CG31650 / 326150	FlyBaseID:	FBgn0031673	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	XP_024307388.1	Gene:	RCN3 / 57333	HGNCID:	21145	Length:	365	Species:	Homo sapiens

Alignment Length:	387	Identity:	121/387 - (31%)
Similarity:	179/387 - (46%)	Gaps:	79/387 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PLTLCAVALL--AAVG-PMPAHGAVANSHKHEKHLSKERVKDGIYAP-RDAHHHGEDGEHNVEFD 69
            |..|..:.||  .|.| |.|..|.......|:.            || .||.|  :|...|.::|
Human     5 PSVLLLLLLLRHGAQGKPSPDAGPHGQGRVHQA------------APLSDAPH--DDAHGNFQYD 55

  Fly    70 HEAIIGNTKEAQEFDSLSPDESKRRLLILIKMMDL--NKDEFIDRHELKAWILRSFKKLSEEEAA 132
            |||.:|. :.|:|||.|:|:||:.||..::..||.  :.|.::...||:|||..:.::...:..:
Human    56 HEAFLGR-EVAKEFDQLTPEESQARLGRIVDRMDRAGDGDGWVSLAELRAWIAHTQQRHIRDSVS 119

  Fly   133 DRFEEIDQDADERITWKEYLQDTYA--MEDEDFKKETIDYDSYEDEQKMIKQDKEMFNAADTNKD 195
            ..::..|.|.|.|:.|:|....||.  ...|:|.    |.:..|..:||:.:|:..|..||.:.|
Human   120 AAWDTYDTDRDGRVGWEELRNATYGHYAPGEEFH----DVEDAETYKKMLARDERRFRVADQDGD 180

  Fly   196 GVLTLEEFVLFQNPEEHPQM-------------------------------------LPILLEHT 223
            .:.|.||...|.:|||.|.|                                     .|.||:.|
Human   181 SMATREELTAFLHPEEFPHMRDIVIALPGAKFPREPLTLTPGVQPPPGARVIGPQPQCPFLLQET 245

  Fly   224 MQDKDADHDGKINFQEFVGDAAS----HHDKEWLITEKERFDKDHDSNGDGVLTGDEVLSWIVPS 284
            ::|.|.:.||.:..:|::.|..|    ..:..|:.||:::|....|.|.||.|.|.||..|::|.
Human   246 LEDLDRNKDGYVQVEEYIADLYSAEPGEEEPAWVQTERQQFRDFRDLNKDGHLDGSEVGHWVLPP 310

  Fly   285 NTAIAND----EVDHLFVSTDEDHDDRLSYLEILNNYDTFVGSEATDYGDHLQNINHLSDEL 342
                |.|    |.:||...:|.|.|.|||..|||.|::.||||:||:||:.|.. :|  |||
Human   311 ----AQDQPLVEANHLLHESDTDKDGRLSKAEILGNWNMFVGSQATNYGEDLTR-HH--DEL 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31650	NP_001162879.1	EF-hand_7	100..153	CDD:290234	14/54 (26%)
		EFh	100..153	CDD:298682	14/54 (26%)
		EF-hand_7	184..241	CDD:290234	22/93 (24%)
		EFh	184..241	CDD:298682	22/93 (24%)
		EFh	228..281	CDD:298682	18/56 (32%)
RCN3	XP_024307388.1	EFh_CREC_RCN3	44..348	CDD:320028	95/314 (30%)
		EF-hand motif	44..73	CDD:320028	13/31 (42%)
		EF-hand motif	79..110	CDD:320028	10/30 (33%)
		EF-hand motif	117..146	CDD:320028	8/28 (29%)
		EF-hand motif	167..196	CDD:320028	10/28 (36%)
		EF-hand motif	204..270	CDD:320028	11/65 (17%)
		EF-hand motif	282..311	CDD:320028	12/32 (38%)
		EF-hand motif	318..348	CDD:320028	14/29 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820